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Curcumin modulates the apolipoprotein B mRNA editing by coordinating the expression of cytidine deamination to uridine editosome components in primary mouse hepatocytes

He P, Tian N

Curcumin, an active ingredient of Curcuma longa L., can reduce the concentration of low-density lipoproteins in plasma, in different ways. We had first reported that curcumin exhibits hypocholesterolemic properties by...
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Correlation of UGT2B7 Polymorphism with Cardiotoxicity in Breast Cancer Patients Undergoing Epirubicin/Cyclophosphamide-Docetaxel Adjuvant Chemotherapy

Li H, Hu B, Guo Z, Jiang X, Su X, Zhang X

PURPOSE: The present study aimed to investigate correlations between uridine glucuronosyltransferase 2B7 (UGT2B7) -161 single nucleotide polymorphism C to T (C>T) and the occurrence of cardiotoxicity in Chinese breast cancer...
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Correlation between laxative effects of uridine and suppression of ER stress in loperamide induced constipated SD rats

Kim JE, Song BR, Yun WB, Choi JY, Park JJ, Lee MR, Hwang DY

A correlation between endoplasmic reticulum (ER) stress and laxative effects was first reported in a constipation model treated with an aqueous extract of Liriope platyphylla (AEtLP) roots. To investigate the...
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Overexpression of Uridine-Cytidine Kinase 2 Correlates with Breast Cancer Progression and Poor Prognosis

Shen G, He P, Mao Y, Li P, Luh F, Ding G, Liu X, Yen Y

PURPOSE: Uridine-cytidine kinase (UCK) 2 is a rate-limiting enzyme involved in the salvage pathway of pyrimidine-nucleotide biosynthesis. Recent studies have shown that UCK2 is overexpressed in many types of cancer...
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Effects of Homogentisic Acid and Natural Products Derived from Pinellia ternata on Secretion, Production and Gene Expression of MUC5AC Mucin from Cultured Airway Epithelial Cells

Lee HJ, Lee CJ

In this study, we investigated whether adenosine, adenine, uridine and homogentisic acid derived from Pinellia ternata affect the secretion, production and gene expression of MUC5AC mucin from airway epithelial cells....
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Chemical Constituents Identified from Fruit Body of Cordyceps bassiana and Their Anti-Inflammatory Activity

Suh W, Nam G, Yang WS, Sung GH, Shim SH, Cho JY

Cordyceps bassiana is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. This mushroom has recently demonstrated to have an ability to reduce 2,4-dinitrofluorobenzene-induced atopic...
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Pestalotiolide A, a New Antiviral Phthalide Derivative from a Soft Coral-derived Fungus Pestalotiopsis sp.

Jia YL, Guan FF, Ma J, Wang CY, Shao CL

Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3...
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Hope for Cirrhosis Patients with Genotype 1 Hepatitis C Virus Who Failed the Previous Treatment

Kwon JH

No abstract available.
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Isolation and Structure Determination of an Imidazo-pyrimidine, 5-Chlorocavernicolin, Maleimide oximes and Nucleosides from a Marine Sponge Extract

Kulkarni R, Kim JH, Kim YH, Oh S, Na M

In a continuation of our studies to discover bioactive secondary metabolites from marine sources, we further investigated samples from a tryptamine and phenyl-alkane producing sponge, which resulted in the isolation...
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Molecular Analysis of the UGT1A1 Gene in Korean Patients with Crigler-Najjar Syndrome Type II

Ko JS, Chang JY, Moon JS, Yang HR, Seo JK

  • KMID: 2315463
  • Pediatr Gastroenterol Hepatol Nutr.
  • 2014 Mar;17(1):37-40.
PURPOSE: Crigler-Najjar syndrome type II (CN-2) is characterized by moderate non-hemolytic unconjugated hyperbilirubinemia as a result of severe deficiency of bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1). The study investigated the mutation spectrum...
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Molecular Typing of Cryptococcus neoformans Isolated from Korean Patients

Park SH, Cho SI, Hwang SM

Cyptococcosis is generally caused by Cryptococcus neoformans, the opportunistic agent which has two species such as C. neoformans and C. gattii. Both C. neoformans and C. gattii species contain a...
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Pharmacokinetics of Uridine Following Ocular, Oral and Intravenous Administration in Rabbits

Kim E, Kang W

  • KMID: 1502520
  • Biomol Ther.
  • 2013 Mar;21(2):170-172.
The pyrimidine nucleoside uridine has recently been reported to have a protective effect on cultured human corneal epithelial cells, in an animal model of dry eye and in patients. In...
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Neuroprotective effects of L-carnitine against oxygen-glucose deprivation in rat primary cortical neurons

Kim YJ, Kim SY, Sung DK, Chang YS, Park WS

PURPOSE: Hypoxic-ischemic encephalopathy is an important cause of neonatal mortality, as this brain injury disrupts normal mitochondrial respiratory activity. Carnitine plays an essential role in mitochondrial fatty acid transport and...
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Molecular Typing of Clinical Cryptococcus gattii Isolates in Korea

Hwang SM

Cryptococcus gattii causes life-threatening yeast infection in the pulmonary and central nervous systems of humans and animals, and traditionally has been considered to restrict into the tropical and subtropical areas....
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Uridine-5'-Triphosphate Stimulates Chloride Secretion via Cystic Fibrosis Transmembrane Conductance Regulator and Ca2+-Activated Chloride Channels in Cultured Human Middle Ear Epithelial Cells

Son EJ, Gee HY, Lee MG, Lee WS, Choi JY

BACKGROUND AND OBJECTIVES: Nucleotide binding to purinergic P2Y receptors contributes to the regulation of fluid and ion transport in the middle ear epithelial cells. Here, we investigated the regulatory mechanism...
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Serial Expression of Hypoxia Inducible Factor-1alpha and Neuronal Apoptosis in Hippocampus of Rats with Chronic Ischemic Brain

Yu CH, Moon CT, Sur JH, Chun YI, Choi WH, Yhee JY

OBJECTIVE: The purpose of this study is to investigate serial changes of hypoxia-inducible factor 1alpha (HIF-1alpha), as a key regulator of hypoxic ischemia, and apoptosis of hippocampus induced by bilateral...
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A Case of Gilbert's Syndrome with Severe Neonatal Hyperbilirubinemia

Hong YS, Jin JY, Lee WR

  • KMID: 2321501
  • J Korean Soc Neonatol.
  • 2010 Nov;17(2):266-269.
Gilbert's syndrome is caused by a reduction in the activity of uridine diphosphate glucuronosyltransferase (UGT) and induces chronic, non-hemolytic unconjugated hyperbilirubinemia. It has been suggested that 3-10% of the population...
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Is it Possible to Perform Chest Compression in Various Alternative Positions in a Confined Space?: A Manikin and Simulation Study

Kim YM, Park SO, Lee KR, Hong DY, Baek KJ

  • KMID: 2332782
  • J Korean Soc Emerg Med.
  • 2010 Aug;21(4):417-422.
PURPOSE: Standard chest compression is useful for cardiopulmonary resuscitation of victims but may be difficult to perform in a confined space if the victim is lying on his side. The...
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A Case of Infantile Hepatic Hemangioendothelioma Incidentally Detected during the Evaluation of Galactosemia

Lim RK, Byun SY, Park SS, Kim YD

  • KMID: 2144479
  • J Korean Soc Neonatol.
  • 2010 May;17(1):136-140.
Galactosemia is a group of inherited enzyme deficiencies characterized by increase in the blood galactose levels. This condition may be associated with deficiencies of galactose-1-phosphate uridyl transferase, galactokinase, or uridine...
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Preliminary Effects of Oral Uridine on the Ocular Surface in Dry Eye Patients

Chang KC, Oh JY, In YS, Kim MK, Shin KC, Wee WR, Lee JH, Park MG

We designed a randomized, double blinded, 3-months controlled prospective clinical study to investigate effects of oral uridine on the ocular surface in dry eye patients. Twenty-seven patients who diagnosed as...
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