Nat Prod Sci.  2015 Dec;21(4):227-230. 10.20307/nps.2015.21.4.227.

Pestalotiolide A, a New Antiviral Phthalide Derivative from a Soft Coral-derived Fungus Pestalotiopsis sp.

• Jia YL
• Guan FF
• Ma J
• Wang CY
• Shao CL

• KMID: 2312900
• DOI: http://doi.org/10.20307/nps.2015.21.4.227

Abstract

Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3 and 4), along with 5'-O-acetyl uridine (5) first isolated as a natural product. The structure of the new compound (1) was established by comprehensive spectroscopic analysis and chemical methods. Compounds 1 - 4 possessed varying degrees of antiviral activities, which was reported for the first time. Compared to the positive control ribavirin (IC50 = 418.0 microM), pestalotiolide A (1) exhibited significant anti-EV71 activity in vitro, with an IC50 value of 27.7 microM. Furthermore, the preliminary structure-activity relationship of antiviral activities was also discussed.

Keyword

Marine Fungus; Pestalotiopsis sp.; Structure-Activity Relationship; Antiviral Activity

MeSH Terms

Fermentation
Fungi*
Inhibitory Concentration 50
Ribavirin
Structure-Activity Relationship
Uridine
Ribavirin
Uridine

Figure

• 

  Fig. 1. The structures of 1 - 5 isolated from Pestalotiopsis sp.

• 

  Fig. 2. Key HMBC () correlations of 1.

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