Nat Prod Sci.
2024 Mar;30(1):59-63. 10.20307/nps.2024.30.1.59.
A New Ring-opened Azaphilone from a Fungus Talaromyces sp. FB15
- Affiliations
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- 1Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
- 2Herbal Medicine Resources Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea
- 3College of Pharmacy, Duksung Women’s University, Seoul 01369, Republic of Korea
- KMID: 2555446
- DOI: http://doi.org/10.20307/nps.2024.30.1.59
Abstract
- Eleven compounds (1–11), including a new azaphilone derivative (1), were isolated from cultures of Talaromyces sp. FB15, a marine fungus collected in the Beaufort Sea in northern Alaska. The structures of the isolated compounds were established by analysis of 1D and 2D NMR data, and they all were turned out to be polyketides such as azaphilone, anthraquinone, and anthrones. Interestingly, the structure of the new metabolite (1) was determined to have an azaphilone scaffold with the pyran ring opened, and to our knowledge, this is the second report on the isolation of this type of azaphilones.
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