- NDRG2 Promotes GATA-1 Expression through Regulation of the JAK2/STAT Pathway in PMA-stimulated U937 Cells
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Kang K, Jung H, Nam S, Lim JS
- KMID: 2150719
- Immune Netw.
- 2011 Dec;11(6):348-357.
- doi: 10.4110/in.2011.11.6.348
BACKGROUND: N-myc downstream-regulated gene 2 (NDRG2), a member of a newly described family of differentiation-related genes, has been characterized as a regulator of dendritic cells. However, the role of NDRG2... -
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- Effect of Eicosapentaenoic Acid on Endothelial Cell-U937 Cell Adhesion
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Chae SC, Kim EJ, Lim HJ, Cheong ER, Cho YK, Jun JE, Park WH
- KMID: 2145716
- Korean Circ J.
- 1998 Apr;28(4):606-610.
- doi: 10.4070/kcj.1998.28.4.606
BACKGROUND: Epidemiological studies have shown correlation between low incidence of coronary heart disease and high consumption of fish products. It has been suggested that this may be due to the... -
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- HS-1200 Overcomes the Resistance Conferred by Bcl-2 in Human Leukemic U937 Cells
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Park JY, Moon JB, Kim IR, Kim GC, Park BS, Kwak HH
- KMID: 1436476
- Int J Oral Biol.
- 2012 Sep;37(3):91-102.
Bcl-2 protects tumor cells from the apoptotic effects of various anti-neoplastic agents. Increased expression of Bcl-2 has been associated with a poor response to chemotherapy in various malignancies, including leukemia.... -
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- NDRG2-mediated Modulation of SOCS3 and STAT3 Activity Inhibits IL-10 Production
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Lee EB, Kim A, Kang K, Kim H, Lim JS
- KMID: 2150678
- Immune Netw.
- 2010 Dec;10(6):219-229.
- doi: 10.4110/in.2010.10.6.219
BACKGROUND: N-myc downstream regulated gene 2 (NDRG2) is a member of the NDRG gene family. Our previous report indicated a possible role for NDRG2 in regulating the cytokine, interleukin-10 (IL-10),... -
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- Identification and Functional Characterization of Differentially Expressed Genes in Human-derived Monocytic Cell Line U937 Infected with Mycobacterium tuberculosis H37Rv and Mycobacterium marinum: Comparative Evaluation of IL-8
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Song CH, Lee JS, Kim HJ, Park JK, Paik TH, Jo EK
- KMID: 2054962
- J Bacteriol Virol.
- 2002 Dec;32(4):401-410.
Although Mycobacterium marinum is closely related to M. tuberculosis H37Rv (M. tbc) genomically, clinical outcome of human infection is quite different. The role of the host macrophage in determining differential... -
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- Molecular association of CD98, CD29, and CD147 critically mediates monocytic U937 cell adhesion
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Kim MY, Cho JY
- KMID: 2350508
- Korean J Physiol Pharmacol.
- 2016 Sep;20(5):515-523.
- doi: 10.4196/kjpp.2016.20.5.515
Adhesion events of monocytes represent an important step in inflammatory responses induced by chemokines. The β1-integrin CD29 is a major adhesion molecule regulating leukocyte migration and extravasation. Although several adhesion... -
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- The effects of differentiation and glucocorticoid treatment on the expression of lipocortin 1 in U937 cells
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Cho YJ, Moon HB, Na DS
- KMID: 1543163
- Korean J Allergy.
- 1997 Jun;17(2):119-128.
Lipocortin represents a family of similar Ca++ depentent phospholipid-binding proteins capable of blocking the activity of phospholipase A2 (PLA2) in vitro. Generally, these proteins are believed to inhibit the release... -
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- The Change of c-jun Promoter Activity in TPA-Induced U937 Cells Infected with Human Cytomegalovirus (HCMV)
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Park CG, Kim DJ, Kim JH, Han TH, Hwang ES, Choi MS, Kook YH, Choi SB, Cha CY
- KMID: 2096747
- J Korean Soc Virol.
- 1999 Jun;29(2):129-136.
Transient transfection assay has been done to evaluate whether the c-jun activation would be prerequisite to the induction of permissiveness against human cytomegalovirus using in vitro cell model in which... -
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- Inhibitory Effects of CD99-derived Peptide CD99CRIII3 on the Extravasation of Monocytes and Inflammatory Reactions in Contact Dermatitis Mouse Model
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Ju HM, Park KH
- KMID: 2430459
- Korean J Phys Anthropol.
- 2018 Dec;31(4):143-149.
- doi: 10.11637/kjpa.2018.31.4.143
Leucocyte extravasation has been known to play an important role in inflammatory reactions including contact dermatitis. Previous studies suggested that CD99 regulates β1 integrin activity and may be a novel... -
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- Adriamycin Induces Apoptosis of Human Myeloid Leukemic U937 Cells via Activation of Caspase-3 and cJun-N Terminal Kinase1(JNK1)/Stress Activated Protein Kinase(SAPK)
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Choi DY, Jung BH, So HS
- KMID: 1535333
- Korean J Pediatr Hematol Oncol.
- 1998 Oct;5(2):285-292.
PURPOSE: Recent studies indicate that widely used chemotherapeutic agents induce apoptosis in susceptible cells. One of the effector arms in this cell death pathway is composed of cysteine proteases belonging... -
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- Induction of Apoptosis Scutellaria baicalensis Georgi Root Extract by Inactivation of the Phosphatidyl Inositol 3-kinase/Akt Signaling Pathway in Human Leukemia U937 Cells
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Choi EO, Hwang HJ, Choi YH
- KMID: 2447436
- J Cancer Prev.
- 2019 Mar;24(1):11-19.
- doi: 10.15430/JCP.2019.24.1.11
BACKGROUND: The roots of Scutellaria baicalensis Georgi (Labiatae) have been widely used in traditional medicine for treatment of various diseases. In this study, we investigated the effects of ethanol extracts... -
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- Zinc-Induced Cell Death in H9c2 Cardiomyoblast cells
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Park C, So HS, Choi HJ, Kim YH, Oh J, Choi MK, Chung YT, Park R
- KMID: 2224525
- Korean J Anat.
- 2000 Dec;33(6):635-642.
Adriamycin (ADR) is a potent anticancer drug that causes often severe cardiomyopathy. Previous reports have demonstrated that zinc accumulation is shown in rat myocardial cells following ADR treatment. However, the... -
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- Effect of Histone H1 on Collagen Induced Arthritis in Mice
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Yang JH, Shin KM, Kim DS
- KMID: 2037362
- Korean J Pediatr.
- 2004 Jul;47(7):779-788.
OBJECTIVE: Besides the functions of histones in the nucleus of the cells, there is growing evidence that histones have many other extra-cellular or extra-nuclear functions, such as stabilizing axonemal microtubule... -
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- The Role of MAPK Signaling of 1,25(OH)2D3-induced CYP24 Expression in Activated Human Macrophages
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Ji JD, Lee BN, Kim TH, Woo JH, Choi SJ, Lee YH, Song GG
- KMID: 2334913
- J Korean Rheum Assoc.
- 2010 Sep;17(3):254-262.
OBJECTIVE: Several important roles of 1,25(OH)2D3 have been recognized in the immune system. The availability of 1,25(OH)2D3 at the cellular level is significantly influenced by the relative abundance of enzymes... -
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- TGF-beta1 inhibition of apoptosis through the transcriptional up-regulation of Bcl-X(L) in human monocytic leukemia U937 cells
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Lee JH, Park BJ, Park JH, Yang MH, Chi SG
- KMID: 755040
- Exp Mol Med.
- 1999 Sep;31(3):126-133.
To characterize the TGF-beta1 response of monocytic leukemia cells, we analyzed the effects of TGF-beta1 on cell proliferation, differentiation, and apoptosis of human monoblastic U937 cells. Treatment of cells with TGF-beta1 in... -
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- Release of heat shock protein 70 (Hsp70) and the effects of extracellular Hsp70 on matric metalloproteinase-9 expression in human monocytic U937 cells
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Lee KJ, Kim YM, Kim DY, Jeoung D, Han K, Lee ST, Lee YS, Park KH, Park JH, Kim DJ, Hahn JH
- KMID: 1110120
- Exp Mol Med.
- 2006 Aug;38(4):364-374.
Heat shock protein 70 (Hsp70) release and its effects on pro-inflammatory cytokine production have been controversial. In this study, we investigated whether Hsp70 could be released from monocytes and activates... -
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- Proteomic analysis of the cellular proteins induced by adaptive concentrations of hydrogen peroxide in human U937 cells
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Seong JK, Kim DK, Choi KH, Oh SH, Kim KS, Lee SS, Um HD
- KMID: 755210
- Exp Mol Med.
- 2002 Nov;34(5):374-378.
When cells are first exposed to low levels of oxidative stress, they develop a resistance to a subsequent challenge of the same stress, even at higher levels. Although some protein(s)... -
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- Induction of apoptosis by a hexane extract of aged black garlic in the human leukemic U937 cells
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Park C, Park S, Chung YH, Kim GY, Choi YW, Kim BW, Choi YH
- KMID: 2313720
- Nutr Res Pract.
- 2014 Apr;8(2):132-137.
BACKGROUND/OBJECTIVES: In this study, the apoptogenic activity and mechanisms of cell death induced by hexane extract of aged black garlic (HEABG) were investigated in human leukemic U937 cells. MATERIALS/METHODS: Cytotoxicity was... -
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- Mycophenolic Acid Induced Apoptotic Signal Transduction in Molt-4 T-cells
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Choi SJ, Chung SY, Kim SK
- KMID: 2004711
- J Korean Surg Soc.
- 2002 Jan;62(1):8-17.
PURPOSE: Mycophenolic acid (MPA), a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), is the active metabolite of the immunosuppressive drug, mycophenolate mofetil (MMF). MMF is used to prevent an immune-... -
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- The Effects of Silica Nanoparticles in Macrophage Cells
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Kim S, Jang J, Kim H, Choi H, Lee K, Choi IH
- KMID: 2150763
- Immune Netw.
- 2012 Dec;12(6):296-300.
- doi: 10.4110/in.2012.12.6.296
Silica nanoparticles, which are applicable in many industrial fields, have been reported to induce cellular changes such as cytotoxicity in various cells and fibrosis in lungs. Because the immune system... -
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