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Physical and Functional Interaction between 5-HT₆ Receptor and Nova-1

Kim SH, Seo M, Hwang H, Moon DM, Son GH, Kim K, Rhim H

5-HT₆ receptor (5-HT₆R) is implicated in cognitive dysfunction, mood disorder, psychosis, and eating disorders. However, despite its significant role in regulating the brain functions, regulation of 5-HT₆R at the molecular...
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Functional Interaction of HIF-1 and NF-kappaB Increasing the Transcriptional Activation of TNF-alpha Gene in Monocytes

Park MJ, Lee SM, Ok SJ, Kim HR, Kim HH, Cheong JH

  • KMID: 1424262
  • Korean J Blood Transfus.
  • 2013 Apr;24(1):21-32.
BACKGROUND: Tumor necrosis factor alpha (TNF-alpha) is a pleiotropic cytokine fulfilling a broad variety of immunoregulatory functions. Monocytes and macrophages play a pivotal role in inflammation and immune regulation. NF-kappaB...
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Characterization of two antimicrobial peptides identified from a random peptide library and expressed in the methylotrophic yeast pichia pastoris

Jeon IS, Song KD, Oh JD, Choi JK

  • KMID: 1703518
  • J Biomed Res.
  • 2013 Dec;14(4):235-239.
Antimicrobial peptides (AMPs) are an important component of innate defense mechanisms with broad-spectrum activities against various pathogenic microorganisms, including Gram-positive and Gram-negative bacteria, fungi, and viruses. Antibiotic resistance has become...
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Identification of Proteins That Interact with Podocin Using the Yeast 2-Hybrid System

Park SJ, Lee BH, Kim DJ

  • KMID: 2396072
  • Yonsei Med J.
  • 2009 Apr;50(2):273-279.
PURPOSE: As a membrane protein at the insertion site of the slit diaphragm (SD) complex in podocyte foot processes, podocin has been reported to act as a scaffolding protein required...
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Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulation

Lee SJ, Lee JK, Maeng YS, Kim YM, Kwon YG

Protein phosphatase-1 (PP1) nuclear targeting subunit (PNUTS), also called PP1R10, p99, or CAT 53 was originally isolated as a mammalian nuclear PP1-binding protein. In this study, we performed yeast two-hybrid...
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The adaptor protein LAD/TSAd mediates laminin-dependent T cell migration via association with the 67 kDa laminin binding protein

Park E, Choi Y, Ahn E, Park I, Yun Y

The adaptor protein, LAD/TSAd, plays essential roles in T cell activation. To further understand the functions of this protein, we performed yeast two-hybrid screening using TSAd as bait and identified...
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Sorting Nexin 17 Interacts Directly with Kinesin Superfamily KIF1B beta Protein

Seog DH, Han J

KIF1B beta is a member of the Kinesin superfamily proteins (KIFs), which are microtubule-dependent molecular motors that are involved in various intracellular organellar transport processes. KIF1B beta is not restricted...
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PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity

Lee SJ, Lee JR, Hah HS, Kim YH, Ahn JH, Bae CD, Yang JM, Hahn MJ

  • KMID: 756067
  • Exp Mol Med.
  • 2007 Aug;39(4):450-457.
Zinc finger protein 133 (ZNF133) is composed of a Kruppel-associated box (KRAB) domain and 14 contiguous zinc finger motifs. ZNF133 is regarded as a transcriptional repressor because the KRAB domain...
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Comparison of shaping ability using various Nickel-Titanium rotary files and hybrid technique

Kim JW, Park JK, Hur B, Kim HC

  • KMID: 2416531
  • J Korean Acad Conserv Dent.
  • 2007 Nov;32(6):530-541.
Currently, various Nickel-Titanium rotary files are used in endodontic treatment, but there is no one perfect system that can be applied to any clinical situation. Therefore, the combined uses of...
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Interactions between secreted GRA proteins and host cell proteins across the paratitophorous vacuolar membrane in the parasitism of Toxoplasma gondii

Ahn HJ, Kim S, Kim HE, Nam HW

Interactions between GRA proteins of dense granules in Toxoplasma gondii and host cell proteins were analyzed by yeast two-hybrid technique. The cMyc-GRA fusion proteins expressed from pGBKT7 plasmid in Y187...
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Kinesin Superfamily KIF1Balpha Protein Binds to the PDZ Domain of MALS-3

Kim SJ, Lee CH, Park HY, Yea SS, Jang WH, Lee SK, Park YH, Jung Y, Seog DH

  • KMID: 2092879
  • Korean J Anat.
  • 2006 Oct;39(5):375-382.
The Kinesin superfamily proteins (KIFs) make up a large superfamily of molecular motors that transport cargo such as vesicles, protein complexes, and organelles. KIF1Balpha is a monomeric motor that conveys mitochondria and...
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C-Terminal Serine Rich Region of IKK-beta Interacts with Bfl-1, a Homologue of Bcl-2

Yoon HK, Kim JK, Cho HJ, Cho MY, Park YP, You KH, Kim JW, Yoon DY, Choe YK, Lee HG

  • KMID: 2082800
  • Korean J Lab Med.
  • 2005 Jun;25(3):192-198.
BACKGROUND: Bcl-2 family proteins play a central role in regulating apoptosis. In human, over 20 members of this family have been identified to date. Bfl-1, a member of the Bcl-2...
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Kinesin Superfamily KIF1A Protein Binds to Synaptotagmin XI

Park HY, Yea SS, Jang WH, Chung JY, Lee SK, Kim SJ, Yang YI, Kim JY, Park YH, Seog DH

  • KMID: 2092858
  • Korean J Anat.
  • 2005 Oct;38(5):403-411.
The kinesin proteins (KIFs) make up a large superfamily of molecular motors that transport cargo such as vesicles, protein complexes, and organelles. KIF1A is a monomeric motor that conveys synaptic vesicle...
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Kinesin Superfamily KIF5 Proteins Bind to betaIII Spectrin

Paik JE, Kim N, Yea SS, Jang WH, Chung JY, Lee SK, Park YH, Han J, Seog DH

  • KMID: 2285302
  • Korean J Physiol Pharmacol.
  • 2004 Jun;8(3):167-172.
The kinesin proteins (KIFs) make up a large superfamily of molecular motors that transport cargo such as vesicles, protein complexes, and organelles. KIF5 is a heterotetrameric motor that conveys vesicles...
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The Effect of Accumulation of Mutant Myocilins in Human Trabecular Meshwork Cells

Joe MK, Kim JM, Kee C

  • KMID: 2126047
  • J Korean Ophthalmol Soc.
  • 2004 May;45(5):840-846.
PURPOSE: To investigate the cellular fate of the mutant myocilins expressed in human trabecular meshwork (TM) cells and their potential cytotoxicity. METHODS: Cultured human TM cells were transduced with adenoviral...
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Identification of a Variant Form of Cellular Inhibitor of Apoptosis Protein (c-IAP2) That Contains a Disrupted Ring Domain

Park SM, Kim JS, Park JH, Kang SG, Lee TH

Among the members of the inhibitor of apoptosis (IAP) protein family, only Livin and survivin have been reported to have variant forms. We have found a variant form of c-IAP2...
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Protein Interaction Databases and Its Application

Kim MK, Park HS

In the past, bioinformatics was often regarded as a difficult and rather remote field, practiced only by computer scientists and not a practical tool available to biologists. However, the various...
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Novel Protein Interactions of G Protein-Coupled Receptor Kinase 5 (GRK5) Searched with Yeast Two-Hybrid System

Jin BC, Park TJ, Kim EJ, Lee JE, Lee JH, Mun IK, Park JR, Choi DJ, Seo BG

BACKGROUND AND OBJECTIVES: G protein-coupled receptors were considered to be the only natural substrates of G protein-coupled receptor kinases (GRKs). However, it was recently demonstrated that GRKs can also bind...
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Inhibition of BETA2/NeuroD by Id2

Ghil SH, Jeon YJ, Suh-Kim H

  • KMID: 755209
  • Exp Mol Med.
  • 2002 Nov;34(5):367-373.
Id (Inhibitor of Differentiation) proteins belong to a family of transcriptional modulators that are characterized by a helix loop helix (HLH) region but lack the basic amino acid domain. Id...
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Inactivation of p73 Protein by Cervical Cancer-inducing HPV E6 Protein Novel p53-independent function of E6

Namkoong S, Kim SJ, Kim EJ, Um SJ, Park JS

  • KMID: 2026746
  • Korean J Obstet Gynecol.
  • 1998 Nov;41(11):2827-2834.
OBJECTIVE: Human papillomavirus (HPV) is strongly implicated as a causative agent in the etiology of cervical cancer. Of its gene products, E6 and E7 oncoproteins play major roles by inactivation...
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