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Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research

Atkinson A

In the conventional concept of translational research, investigations flow from the laboratory bench to the bedside. However, clinical research can also serve as the starting point for subsequent laboratory investigations...
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Korean clinical trials: its current status, future prospects, and enabling environment

Chee DH

No abstract available.
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Treatment response and disease progression

Holford N

This tutorial defines the concepts of disease progression in the context of clinical pharmacology. Disease progression describes the natural history of disease, such as pain, or biomarker of drug response,...
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The problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology

Yum SK, Yum SY, Kim T

While hormonal changes during the ovulatory cycles affect multiple body systems, medical management, including medication dosing remains largely uniform between the sexes. Little is known about sex-specific pharmacology in women....
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Performance of a mixture model by the degree of a missing categorical covariate when estimating clearance in NONMEM

Yoon S, Lim HS

The accuracy and predictability of mixture models in NONMEM® may change depending on the relative size of inter-individual differences and the size of the differences in the parameters between subpopulations....
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A review of three years' experience of the first pharmacometrics company in Korea

Lee SJ, Jeon S

As the pharmaceutical industry in Korea is reaching the golden era of drug discovery due to increased investments in research and development and government funds, the need for a more...
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Pharmacokinetic comparison between fixed-dose combination of fimasartan/amlodipine 60/10 mg and the corresponding loose combination through partial replicated crossover study in healthy subjects

Yang E, Lee S, Lee H, Hwang I, Jang IJ, Yu KS, Lee S

Combination therapies of antihypertensive drugs are recommended in cases where hypertension is not controlled by monotherapy. This study aimed to compare the pharmacokinetics (PKs) between fixed-dose combination (FDC) of fimasartan/amlodipine...
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