- Volume of Distribution
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Holford N, Yim DS
- KMID: 2290472
- Transl Clin Pharmacol.
- 2016 Jun;24(2):74-77.
- doi: 10.12793/tcp.2016.24.2.74
This tutorial deals with basic concepts of volume of distribution, the second most important parameter in pharmacokinetics but often challenging for students in clinical pharmacology. Its relationships with dose, concentration... -
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- Erratum: Pharmacokinetics and bioequivalence of two different 20 mg olmesartan tablets: A randomized, single-dose, two-period crossover study in healthy Korean male volunteers
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Lee J, Kim A, Yu KS, Chung JY, Yim SV, Kim BH
- KMID: 2290478
- Transl Clin Pharmacol.
- 2016 Jun;24(2):111-111.
- doi: 10.12793/tcp.2016.24.2.111
In the published version of this article, an error in the sponsor's identity was discovered in the acknowledgment section. -
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- Problems within the post-marketing surveillance system in Korea: Time for a change
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Song H, Yim DS
- KMID: 2290470
- Transl Clin Pharmacol.
- 2016 Jun;24(2):63-65.
- doi: 10.12793/tcp.2016.24.2.63
Post-marketing safety studies are an important tool for understanding and monitoring the safety profiles of drugs in the clinical setting. Their importance has attracted not only the attention of regulators... -
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- Statistical basis for pharmacometrics: random variables and their distribution functions, expected values, and correlation coefficient
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Choi K
- KMID: 2290471
- Transl Clin Pharmacol.
- 2016 Jun;24(2):66-73.
- doi: 10.12793/tcp.2016.24.2.66
For pharmacometricians, probability theory is the very first obstacle towards the statistics since it is solely founded on mathematics. The purpose of this tutorial is to provide a simple version... -
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- Evaluation of factors associated with drug-induced liver injury using electronic medical records
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Chung H, An H, Lee J, Oh J, Yu KS, Chung JY
- KMID: 2290473
- Transl Clin Pharmacol.
- 2016 Jun;24(2):78-83.
- doi: 10.12793/tcp.2016.24.2.78
The causes and attributing factors of drug-induced liver injury (DILI) remain unclear as a result of exclusion-based diagnosis and low incidence. The aim of this study was to explore and... -
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- Population pharmacokinetics of imatinib mesylate in healthy Korean subjects
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Park GJ, Park WS, Bae S, Park SM, Han S, Yim DS
- KMID: 2290476
- Transl Clin Pharmacol.
- 2016 Jun;24(2):96-104.
- doi: 10.12793/tcp.2016.24.2.96
Imatinib (Gleevecâ„¢; Novartis Pharmaceuticals) is an orally administered protein-tyrosine kinase inhibitor. The goal of this study was to investigate the population pharmacokinetics (PK) of imatinib (as imatinib mesylate) in healthy... -
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- Effects of mirodenafil on the hemodynamics in hypertensive patients taking amlodipine
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Choi HK, Shim EJ, Shon J, Jung JA, Ghim JL, Ryu JH, Bae KS, Shin JG
- KMID: 2290475
- Transl Clin Pharmacol.
- 2016 Jun;24(2):90-95.
- doi: 10.12793/tcp.2016.24.2.90
While phosphodiesterase type 5 inhibitors have been used for erectile dysfunction with acceptable safety profile, they can induce orthostatic hypotension in patients taking antihypertensive drugs with blood pressure lowering effect.... -
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- Pharmacokinetic comparison of two levofloxacin 100-mg tablet formulations and determination of time point appropriately reflecting its area under the curve
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Park KR, Jang K, Lee S, Yu KS, Kim BH, Yim SV
- KMID: 2290474
- Transl Clin Pharmacol.
- 2016 Jun;24(2):84-89.
- doi: 10.12793/tcp.2016.24.2.84
Levofloxacin is a broad-spectrum antibiotic with activity against gram-positive and -negative bacteria. This study compared the pharmacokinetics (PK) and evaluated the bioequivalence of two levofloxacin 100-mg tablet formulations. An open,... -
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- Population pharmacokinetics and inter-laboratory variability of sildenafil and its metabolite after oral administration in Korean healthy male volunteers
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Youn S, Park WS, Park GJ, Jang DY, Bae SH, Han S, Yim DS
- KMID: 2290477
- Transl Clin Pharmacol.
- 2016 Jun;24(2):105-110.
- doi: 10.12793/tcp.2016.24.2.105
This study was to clarify population pharmacokinetics (PK) of sildenafil and its metabolite, N-desmethyl sildenafil (NDS) in Korean healthy male population using a pooled data from multiple clinical trials in... -
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