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Erratum: Pharmacokinetics and bioequivalence of two different 20 mg olmesartan tablets: A randomized, single-dose, two-period crossover study in healthy Korean male volunteers

Lee J, Kim A, Yu KS, Chung JY, Yim SV, Kim BH

In the published version of this article, an error in the sponsor's identity was discovered in the acknowledgment section.
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Population pharmacokinetics and inter-laboratory variability of sildenafil and its metabolite after oral administration in Korean healthy male volunteers

Youn S, Park WS, Park GJ, Jang DY, Bae SH, Han S, Yim DS

This study was to clarify population pharmacokinetics (PK) of sildenafil and its metabolite, N-desmethyl sildenafil (NDS) in Korean healthy male population using a pooled data from multiple clinical trials in...
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Population pharmacokinetics of imatinib mesylate in healthy Korean subjects

Park GJ, Park WS, Bae S, Park SM, Han S, Yim DS

Imatinib (Gleevecâ„¢; Novartis Pharmaceuticals) is an orally administered protein-tyrosine kinase inhibitor. The goal of this study was to investigate the population pharmacokinetics (PK) of imatinib (as imatinib mesylate) in healthy...
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Effects of mirodenafil on the hemodynamics in hypertensive patients taking amlodipine

Choi HK, Shim EJ, Shon J, Jung JA, Ghim JL, Ryu JH, Bae KS, Shin JG

While phosphodiesterase type 5 inhibitors have been used for erectile dysfunction with acceptable safety profile, they can induce orthostatic hypotension in patients taking antihypertensive drugs with blood pressure lowering effect....
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Pharmacokinetic comparison of two levofloxacin 100-mg tablet formulations and determination of time point appropriately reflecting its area under the curve

Park KR, Jang K, Lee S, Yu KS, Kim BH, Yim SV

Levofloxacin is a broad-spectrum antibiotic with activity against gram-positive and -negative bacteria. This study compared the pharmacokinetics (PK) and evaluated the bioequivalence of two levofloxacin 100-mg tablet formulations. An open,...
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Evaluation of factors associated with drug-induced liver injury using electronic medical records

Chung H, An H, Lee J, Oh J, Yu KS, Chung JY

The causes and attributing factors of drug-induced liver injury (DILI) remain unclear as a result of exclusion-based diagnosis and low incidence. The aim of this study was to explore and...
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Volume of Distribution

Holford N, Yim DS

This tutorial deals with basic concepts of volume of distribution, the second most important parameter in pharmacokinetics but often challenging for students in clinical pharmacology. Its relationships with dose, concentration...
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Statistical basis for pharmacometrics: random variables and their distribution functions, expected values, and correlation coefficient

Choi K

For pharmacometricians, probability theory is the very first obstacle towards the statistics since it is solely founded on mathematics. The purpose of this tutorial is to provide a simple version...
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Problems within the post-marketing surveillance system in Korea: Time for a change

Song H, Yim DS

Post-marketing safety studies are an important tool for understanding and monitoring the safety profiles of drugs in the clinical setting. Their importance has attracted not only the attention of regulators...
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