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Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation

Koh YS

Toll-like receptor 9 binds to DNA from bacteria or viruses and activates a signaling pathway that leads to the induction of proinflammatory cytokines and type I interferon. Adaptor complex AP-3...
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Single Nucleotide Polymorphisms of Toll-Like Receptor 7 and Toll-Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China

Wei XS, Wei CD, Tong YQ, Zhu CL, Zhang PA

  • KMID: 2386473
  • Yonsei Med J.
  • 2014 Mar;55(2):428-434.
PURPOSE: To analyze the correlation of polymorphisms of toll-like receptor 7 (TLR7) (rs179009) and toll-like receptor 9 (TLR9) (rs187084) in hepatitis C virus (HCV) infections in the Han population. MATERIALS AND...
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Association between Polymorphisms in Toll-like Receptor 9 Gene and Outcomes after Ischemic Stroke

Choi JC, Lee KH, Kim YR, Ki CS

Several evidences suggested that Toll-like receptor 9 (TLR9) plays an important role in atherosclerosis and neuroprotection but the association between the TLR9 and risk for stroke or outcomes after stroke...
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Association of Toll-Like Receptor Gene with Crohn's Disease in Koreans

Ye BD, Yang SK, Song K, Yang DH, Yoon SM, Kim KJ, Byeon JS, Myung SJ, Kim JH

BACKGROUND/AIMS: Toll-like receptors (TLRs) serve as pattern recognition receptors that recognize specific molecular patterns of pathogens and can mediate the production of proinflammatory cytokines. Recently, TLRs have been identified as...
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Toll-like receptor 9 expression and interferon-alpha secretion upon CpG-ODN stimulation in allergic subjects

Han MY, Jee HM, Kim HY, Lee CA, Cho HJ, Hwang SG, Kim KE

PURPOSE: The aim of this study is to explore the effect of the Toll-like receptor 9 (TLR9) expressed in plasmacytoid dendritic cells (pDCs) that respond to antigen to Th2 immune...
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Association between Toll-Like Receptor 9-1237T/C Polymorphism and the Susceptibility of Inflammatory Bowel Diseases: A Meta-Analysis

Shang J, Wang X, Wang W, Pan H, Liu S, Li L, Chen L, Xia B

PURPOSE: The -1237T/C polymorphism of the Toll-like receptor 9 (TLR9) gene has been implicated in the susceptibility of inflammatory bowel diseases (IBDs), but the results remain conflicting. We further investigated...
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Expression of Toll-Like Receptors in Verruca and Molluscum Contagiosum

Ku JK, Kwon HJ, Kim MY, Kang H, Song PI, Armstrong , Ansel JC, Kim HO, Park YM

Recent studies indicate that several Toll-like receptors (TLRs) are implicated in recognizing viral structures and instigating immune responses against viral infections. The aim of this study is to examine the...
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Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression

Lim EJ, Park DW, Lee JG, Lee CH, Bae YS, Hwang YC, Jeong JW, Chin BR, Baek SH

Synthetic oligodeoxynucleotides (ODN) with a CpG-motif are recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Stimulation of macrophages with TLR9 agonist prevented apoptosis induced by serum...
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Induction of Interleukin-22 (IL-22) production in CD4+ T Cells by IL-17A Secreted from CpG-Stimulated Keratinocytes

Li ZJ, Choi DK, Sohn KC, Lim SK, Im M, Lee Y, Seo YJ, Kim CD, Lee JH

BACKGROUND: Interleukin-17A (IL-17A) is mainly secreted from Th17 cells that are activated by various stimuli including CpG oligodeoxynucleotide, a Toll-like receptor 9 (TLR9) ligand. Recently, it has been demonstrated that...
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Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN-induced matrix metalloproteinase-9 expression

Lim EJ, Lee SH, Lee JG, Kim JR, Yun SS, Baek SH, Lee C

  • KMID: 1094665
  • Exp Mol Med.
  • 2007 Apr;39(2):239-245.
Unmethylated CpG oligodeoxynucleotides (CpG ODNs) activate immune cells to produce immune mediators. This study demonstrates that in murine macrophage RAW 264.7 cells, CpG ODN-mediated matrix metalloproteinase-9 (MMP-9) expression is regulated...
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