Korean J Gastroenterol.  2009 Dec;54(6):377-383. 10.4166/kjg.2009.54.6.377.

Association of Toll-Like Receptor Gene with Crohn's Disease in Koreans

• Ye BD
• Yang SK
• Song K
• Yang DH
• Yoon SM
• Kim KJ
• Byeon JS
• Myung SJ
• Kim JH

• KMID: 1775937
• DOI: http://doi.org/10.4166/kjg.2009.54.6.377

Abstract

BACKGROUND/AIMS
Toll-like receptors (TLRs) serve as pattern recognition receptors that recognize specific molecular patterns of pathogens and can mediate the production of proinflammatory cytokines. Recently, TLRs have been identified as susceptibility genes for Crohn's disease (CD) in several studies from Western populations. We investigated the association of genetic variations in TLR4 and TLR9 with CD in Korean population. METHODS: In 380 CD cases and 380 healthy controls, we performed genotyping for TLR4 Asp299Gly (rs4986790) and Thr399Ile (rs4986791). The genetic variations in the TLR9 -1237T/C (rs5743836) were also examined. RESULTS: Among CD patients genotyped for TLR4 Asp299Gly and TLR9 -1237T/C, none had variant alleles. Similarly, none of the subjects genotyped for TLR4 Thr399Ile showed genetic variations. CONCLUSIONS: Our results indicate that the major genetic variations in TLR4 and TLR9 are rare and may not be associated with susceptibility to CD in Koreans.

Keyword

Crohn's disease; Toll-like receptor; Korea

MeSH Terms

Adolescent
Adult
Alleles
Asian Continental Ancestry Group/*genetics
Crohn Disease/diagnosis/ethnology/*genetics
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Republic of Korea
Toll-Like Receptor 4/*genetics
Toll-Like Receptor 9/*genetics

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