- Thapsigargin Increases IL-2 Production in T Cells at Nanomolar Concentrations
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Kim KH, Kim SH, Jung HH, Moon JH, Jeong SU, Yu K, Lee CK
- KMID: 2419771
- Immune Netw.
- 2018 Aug;18(4):e26.
- doi: 10.4110/in.2018.18.e26
Thapsigargin (TGN) is a potent and selective inhibitor of sarco-endoplasmic Ca²âº-ATPase, leading to rapid elevation of cytoplasmic Ca2+ concentration. Previous reports have shown that TGN increases the production of various... -
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- Sequestration of sorcin by aberrant forms of tau results in the defective calcium homeostasis
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Kim SI, Lee HJ, Kim SS, Kwon YS, Chun W
- KMID: 2371056
- Korean J Physiol Pharmacol.
- 2016 Jul;20(4):387-397.
- doi: 10.4196/kjpp.2016.20.4.387
Neurofi brillary tangles (NFTs) of microtubule-associated protein tau are a pathological hallmark of Alzheimer's disease (AD). Endoplasmic reticulum (ER) stress has been known to be involved in the pathogenesis of... -
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- The Effects of DTBNP on Intracellular Ca2+ Signaling in Cultured Bovine Aortic Endothelial Cells
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Park SJ, Kim BJ, Zhu MH, So I, Kim KW
- KMID: 2071617
- Korean J Physiol Pharmacol.
- 2005 Dec;9(6):341-346.
The mechanism underlying oxidant-induced intracellular Ca2+ ([Ca2+]i) increase was studied in cultured bovine aortic endothelial cells (BAECs) using fura-2 AM. In the presence of 2 mM extracellular Ca2+, the application... -
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- alpha-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation
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Kim SJ, Hong EH, Lee BR, Park MH, Kim JW, Pyun AR, Kim YJ, Chang SY, Chin YW, Ko HJ
- KMID: 2150757
- Immune Netw.
- 2012 Dec;12(6):253-260.
- doi: 10.4110/in.2012.12.6.253
alpha-Mangostin is a xanthon derivative contained in the fruit hull of mangosteen (Garcinia mangostana L.), and the administration of alpha-Mangostin inhibited the growth of transplanted colon cancer, Her/CT26 cells which... -
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- Ca2+-induced Ca2+ Release from Sarcoplasmic Reticulum Negatively Regulates Myocytic ANP Release in Beating Rabbit Atria
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Li D, Quan HX, Wen JF, Jin JY, Park SH, Kim SY, Kim SZ, Cho KW
- KMID: 2285314
- Korean J Physiol Pharmacol.
- 2005 Apr;9(2):87-94.
It is not clear whether Ca2+-induced Ca2+ release from the sarcoplasmic reticulum (SR) is involved in the regulation of atrial natriuretic peptide (ANP) release. Previously, we have shown that nifedipine... -
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- Role of Gap Junction in the Regulation of Renin Release and Intracellular Calcium in As 4.1 Cell Line
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Han JH, Hong BZ, Kwak YG, Yuan K, Park WH, Kim SZ, Kim SH
- KMID: 2285333
- Korean J Physiol Pharmacol.
- 2007 Jun;11(3):107-112.
Gap junction protein, connexin, is expressed in endothelial cells of vessels, glomerulus, and renin secreting cells of the kidney. The purpose of this study was to investigate the role of... -
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- SM709, Ingredient of Antimelanogenic Bamboo Extract, Blocks Endothelin-1-induced [Ca2+]i Increase in Human Melanocytes
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Kim SH, Lee KM, Kim HS, Lee GS, Jeon BH, Kim KJ, Park JB
- KMID: 1607515
- Korean J Physiol Pharmacol.
- 2003 Dec;7(6):311-316.
Endothelins secreted from keratinocytes are intrinsic mitogens and melanogens of human melanocytes in UVB-induced hyperpigmentation. To elucidate the cellular mechanism of antimelanogenic activity of bamboo extract, the effects of three... -
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- Ryanodine Receptor-mediated Calcium Release Regulates Neuronal Excitability in Rat Spinal Substantia Gelatinosa Neurons
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Park A, Chun SW
- KMID: 2133226
- Int J Oral Biol.
- 2015 Dec;40(4):211-216.
- doi: 10.11620/IJOB.2015.40.4.211
Nitric Oxide (NO) is an important signaling molecule in the nociceptive process. Our previous study suggested that high concentrations of sodium nitroprusside (SNP), a NO donor, induce a membrane hyperpolarization... -
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- Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion
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Cho JA, Park E
- KMID: 2313818
- Nutr Res Pract.
- 2015 Apr;9(2):117-122.
- doi: 10.4162/nrp.2015.9.2.117
BACKGROUND/OBJECTIVES: Curcumin, a major component of the Curcuma species, contains antioxidant and anti-inflammatory properties. Although it was found to induce apoptosis in cancer cells, the functional role of curcumin as... -
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- Peptidoglycan Induces the Production of Interleukin-8 via Calcium Signaling in Human Gingival Epithelium
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Son A, Shin DM, Hong JH
- KMID: 2071819
- Korean J Physiol Pharmacol.
- 2015 Jan;19(1):51-57.
- doi: 10.4196/kjpp.2015.19.1.51
The etiology of periodontal disease is multifactorial. Exogenous stimuli such as bacterial pathogens can interact with toll-like receptors to activate intracellular calcium signaling in gingival epithelium and other tissues. The... -
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- Mechanism of vasodilation by propofol in the rabbit renal artery
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Park SY, Jung I, Kwon SC
- KMID: 2263234
- Anesth Pain Med.
- 2011 Oct;6(4):336-341.
BACKGROUND: Propofol directly inhibits vascular reactivity. However, available information regarding the underlying mechanisms of propofol is poor. Therefore, mechanisms of the underlying relaxant action of propofol were investigated using rabbit... -
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- The Effect of Tribbles-Related Protein 3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells
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Jang YY, Kim NK, Kim MK, Lee HY, Kim SJ, Kim HS, Seo HY, Lee IK, Park KG
- KMID: 2029889
- Korean Diabetes J.
- 2010 Oct;34(5):312-319.
- doi: 10.4093/kdj.2010.34.5.312
BACKGROUND: The highly developed endoplasmic reticulum (ER) structure in pancreatic beta cells is heavily involved in insulin biosynthesis. Thus, any perturbation in ER function inevitably impacts insulin biosynthesis. Recent studies... -
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- Protective Effect of PKC Affecting Taxol-induced Cytotoxicity in MCF-7 Cells
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Oh JM, Jung KM, Bang HJ, So HS, Park RK, Kim JJ, Choi MK, Park ST, Chung YT
- KMID: 2224545
- Korean J Anat.
- 2000 Oct;33(5):571-578.
Paclitaxel (taxol) is known as effective drug inhibition of cell cycle encouraging activity in human ovarian and metastatic breast cancers and malignant melanoma. It is an antimicrotubule agent that is... -
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- Effects of NaOCl on the Intracellular Calcium Concentration in Rat Dorsal Root Ganglion Neurons
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Lee HI, Chun SW
- KMID: 1457186
- Int J Oral Biol.
- 2010 Sep;35(3):129-135.
Recent studies have implicated reactive oxygen species (ROS) as determinants of the pathological pain caused by the activation of peripheral neurons. It has not been elucidated, however, how ROS activate... -
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- Intracellular Ca2+ Mobilization and Beta-hexosaminidase Release Are Not Influenced by 60 Hz-electromagnetic Fields (EMF) in RBL 2H3 Cells
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Hwang YH, Song HS, Kim HR, Ko MS, Jeong JM, Kim YH, Ryu JS, Sohn UD, Gimm YM, Myung SH, Sim SS
- KMID: 2071735
- Korean J Physiol Pharmacol.
- 2011 Oct;15(5):313-317.
- doi: 10.4196/kjpp.2011.15.5.313
The effects of extremely low frequency electromagnetic fields (EMF) on intracellular Ca2+ mobilization and cellular function in RBL 2H3 cells were investigated. Exposure to EMF (60 Hz, 0.1 or 1... -
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- Forward-mode Na+ - Ca2+ exchange during depolarization in the rat ventricular myocytes with high EGTA
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Kim EG, Ko CM
- KMID: 1607137
- Korean J Physiol Pharmacol.
- 2001 Dec;5(6):487-494.
During depolarization, extrusion of Ca2+ from sarcoplasmic reticulum through forward-mode Na+ - Ca2+ exchange was studied in the rat ventricular myocytes patch-clamped in whole-cell configuration. In order to confine the... -
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- The Effect of Calcium Modulators on Motoneuron Cells Which Express Mutated Cu / Zn Superoxide Dismutase
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Kim SH, Kim HJ, Kim M, Lee KW
- KMID: 2343064
- J Korean Neurol Assoc.
- 2003 Oct;21(5):521-526.
BACKGROUND: Intracellular calcium accumulation and dys-regulation is known as one of the mechanism in motor neuronal degeneration with mutations in Cu/Zn superoxide dismutase (SOD-1). METHODS: To investigate the calcium modulators... -
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- Effects of NaOCl on Neuronal Excitability and Intracellular Calcium Concentration in Rat Spinal Substantia Gelatinosa Neurons
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Lee HI, Park AR, Chun SW
- KMID: 1431123
- Int J Oral Biol.
- 2013 Mar;38(1):5-12.
Recent studies indicate that reactive oxygen species (ROS) can act as modulators of neuronal activity, and are critically involved in persistent pain primarily through spinal mechanisms. In this study, we... -
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- Efffects of Fluoxetine on ATP-induced Calcium Signaling in PC12 Cells
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Lee YM, Kim HJ, Hong SH, Kim MJ, Min DS, Rhie DJ, Kim MS, Jo YH, Hahn SJ, Yoon SH
- KMID: 1517038
- Korean J Physiol Pharmacol.
- 2004 Feb;8(1):57-63.
Fluoxetine, a widely used anti-depressant compound, has several additional effects, including blockade of voltage-gated ion channels. We examined whether fluoxetine affects ATP-induced calcium signaling in PC12 cells by using fura-2-based... -
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- Effects of Reactive Oxygen Species on ATP-induced intracellular Ca2+ Activity in Osteoblasts
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Kim JH, Kwon TD, Nam SH, Suh CK, Hong YW
- KMID: 1860817
- Korean J Anesthesiol.
- 2003 Apr;44(4):544-554.
- doi: 10.4097/kjae.2003.44.4.544
BACKGORUND: The physiological activity of osteoblsts is known to be closely related to increased intracellular Ca2+ activity ([Ca2+ ]i) in osteoblasts. The cellular regulation of ([Ca2+ ]i) in osteoblasts... -
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