- A Study of the Balance of Th17 Cells and Regulatory T Cells in Psoriasis
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Na CH, Kim DJ, Kim MS, Shin BS
- KMID: 2251145
- Korean J Dermatol.
- 2016 May;54(4):268-274.
BACKGROUND: Although the pathogenesis of psoriasis is not fully understood, recent studies suggest that an imbalance of T-helper 17 cells (Th17) and CD4+CD25+Foxp3+ regulatory T cells (Treg) is associated with... -
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- A Study of the Changes of T Helper 17 Cells and Regulatory T Cells in Herpes Zoster
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Kim MS, Kim DJ, Na CH, Shin BS
- KMID: 2388909
- Ann Dermatol.
- 2017 Oct;29(5):578-585.
- doi: 10.5021/ad.2017.29.5.578
BACKGROUND: Immunosuppression and age-related deficiencies in cell-mediated immunity are important factors for the reactivation of latent varicella-zoster virus (VZV). CD4âºCD25âºFoxp3⺠regulatory T (Treg) cells and T helper 17 (Th17) cells... -
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- Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma
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Nakajima H, Hirose K
- KMID: 1456191
- Immune Netw.
- 2010 Feb;10(1):1-4.
- doi: 10.4110/in.2010.10.1.1
Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as... -
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- Clinical significance of Th17 cells in kidney transplantation
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Chung BH, Yang CW, Cho ML
- KMID: 2419996
- Korean J Intern Med.
- 2018 Sep;33(5):860-866.
- doi: 10.3904/kjim.2018.095
Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However,... -
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- Genetic controls of Th17 cell differentiation and plasticity
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Dong C
- KMID: 991617
- Exp Mol Med.
- 2011 Jan;43(1):1-6.
- doi: 10.3858/emm.2011.43.1.007
CD4+ T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naive T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2... -
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- Regulation and Function of Th17 Cells
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- KMID: 2090204
- Korean J Asthma Allergy Clin Immunol.
- 2011 Mar;31(1):1-8.
Naive CD4+ helper T (Th) cells, upon activation by antigen-presenting cells (APC), differentiate into different types of effecter cells that are characterized by their distinct cytokine production profiles and immune... -
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- Role of Th17 Cell and Autoimmunity in Chronic Obstructive Pulmonary Disease
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Hong SC, Lee SH
- KMID: 2150668
- Immune Netw.
- 2010 Aug;10(4):109-114.
- doi: 10.4110/in.2010.10.4.109
The molecular mechanisms involved in the pathogenesis of chronic obstructive pulmonary disease (COPD) are poorly defined. Accumulating evidences indicate that chronic inflammatory responses and adaptive immunity play important roles in... -
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- Targeting Interleukin-17 and Th17 in Immune Inflammatory Diseases
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Cho MR
- KMID: 2168216
- Hanyang Med Rev.
- 2013 Feb;33(1):17-26.
- doi: 10.7599/hmr.2013.33.1.17
Th17 cells (Th17) are a distinct lineage of CD4+ T cells that secrete high amounts of IL-17 under orphan nuclear receptor retinoic acid receptor-related orphan receptor gammat (RORgammat) which is... -
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- Th17 Responses Are Not Induced in Dextran Sodium Sulfate Model of Acute Colitis
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Kim YS, Lee MH, Ju AS, Rhee KJ
- KMID: 2150729
- Immune Netw.
- 2011 Dec;11(6):416-419.
- doi: 10.4110/in.2011.11.6.416
Dextran sodium sulfate (DSS) is a widely used chemical model for inflammatory bowel disease (IBD). It is thought that imbalances in the T helper (Th) cell subsets contribute to IBD.... -
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- Casein kinase 2 is a critical determinant of the balance of Th17 and Treg cell differentiation
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Jang SW, Hwang SS, Kim HS, Lee KO, Kim MK, Lee W, Kim K, Lee GR
- KMID: 2394306
- Exp Mol Med.
- 2017 Sep;49(9):e375.
- doi: 10.1038/emm.2017.132
Th17 cells promote inflammatory reactions, whereas regulatory T (Treg) cells inhibit them. Thus, the Th17/Treg cell balance is critically important in inflammatory diseases. However, the molecular mechanisms underlying this balance... -
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- Intravenous Immunoglobulin Controls Th17 Cell-Mediated Osteoclastogenesis
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Kim KW, Kim HR, Kim BM, Won JY, Lee KA, Lee SH
- KMID: 2455937
- Immune Netw.
- 2019 Aug;19(4):e27.
- doi: 10.4110/in.2019.19.e27
The purpose of this study was to determine the regulatory role of intravenous Ig (IVIg) in Th17 cytokine–induced RANK ligand (RANKL) expression and osteoclast (OC) differentiation from OC precursors (pre-OC).... -
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- Introduction to Autoimmune Disease
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Kim J, Choe J
- KMID: 2188024
- J Korean Med Assoc.
- 2009 Jul;52(7):638-644.
- doi: 10.5124/jkma.2009.52.7.638
The immune system maintains the integrity of our bodies by warding off intruding microorganisms, but by sustaining tolerance to our own tissues. The immunologic tolerance is established by several layers... -
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- Ciglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Ligand, Inhibits Proliferation and Differentiation of Th17 Cells
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Kim DH, Ihn HJ, Moon C, Oh SS, Park S, Kim S, Lee KW, Kim KD
- KMID: 2380365
- Biomol Ther.
- 2015 Jan;23(1):71-76.
- doi: 10.4062/biomolther.2014.042
Peroxisome proliferator-activated receptor gamma (PPARgamma) was identified as a cell-intrinsic regulator of Th17 cell differentiation. Th17 cells have been associated with several autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE), inflammatory... -
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- Th17 Cells Are Not Directly Associated with Renal Ischemia-Reperfusion Injury
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Chang YK, Choi DE, Jeong JY, Choi HJ, Lim BJ
- KMID: 2080178
- Korean J Nephrol.
- 2011 May;30(3):246-252.
PURPOSE: Interleukin-17-producing T cell (Th17 cell) is a newly discovered subtype of helper T cell. Its function and importance in the pathogenesis of a broad range of immune diseases are... -
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- NF-kappaB Activation in T Helper 17 Cell Differentiation
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Park SH, Cho G, Park SG
- KMID: 1508824
- Immune Netw.
- 2014 Feb;14(1):14-20.
- doi: 10.4110/in.2014.14.1.14
CD28/T cell receptor ligation activates the NF-kappaB signaling cascade during CD4 T cell activation. NF-kappaB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently,... -
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- Elevated Levels of T Helper 17 Cells Are Associated with Disease Activity in Patients with Rheumatoid Arthritis
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Kim J, Kang S, Kim J, Kwon G, Koo S
- KMID: 1781298
- Ann Lab Med.
- 2013 Jan;33(1):52-59.
- doi: 10.3343/alm.2013.33.1.52
BACKGROUND: Interleukin-17 (IL-17)-producing T helper (Th) 17 cells are considered as a new subset of cells critical to the development of rheumatoid arthritis (RA). We aimed to investigate the distribution... -
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- The Effect of Inflammatory Cytokines on the Differentiation of Th17 Cells in Human Peripheral Blood
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Heo YJ, Park MK, Ju JH, Park KS, Cho ML, Kim HY
- KMID: 2202129
- J Korean Rheum Assoc.
- 2009 Jun;16(2):133-143.
- doi: 10.4078/jkra.2009.16.2.133
OBJECTIVE: IL-17-producing T cells (Th17 cells) have been identified as a distinct lineage of CD4+ T helper cells in mice. Since this discovery, many efforts have been made to investigate... -
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- Role of endometrial immune cells in implantation
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Lee JY, Lee M, Lee SK
- KMID: 1973527
- Clin Exp Reprod Med.
- 2011 Sep;38(3):119-125.
- doi: 10.5653/cerm.2011.38.3.119
Implantation of an embryo occurs during the mid-secretory phase of the menstrual cycle, known as the "implantation window." During this implantation period, there are significant morphologic and functional changes in... -
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- Immunohistochemical Analysis of Interleukin-17 Producing T Helper Cells and Regulatory T Cells Infiltration in Annular Erythema Associated with Sjogren's Syndrome
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Itoi S, Tanemura A, Tani M, Kitaba S, Terao M, Murota H, Oiso N, Katayama I
- KMID: 2171656
- Ann Dermatol.
- 2014 Apr;26(2):203-208.
- doi: 10.5021/ad.2014.26.2.203
BACKGROUND: Peculiar erythema known as annular erythema associated with Sjogren's syndrome (AESS) can be differentiated from autoimmune annular erythema and subacute cutaneous lupus erythematosus, both clinically and histologically. However, there... -
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- Regulation of Th2 Cell Immunity by Dendritic Cells
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Na H, Cho M, Chung Y
- KMID: 2154806
- Immune Netw.
- 2016 Feb;16(1):1-12.
- doi: 10.4110/in.2016.16.1.1
Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which... -
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