- Characteristics in Molecular Vibrational Frequency Patterns between Agonists and Antagonists of Histamine Receptors
-
Oh SJ
- KMID: 2166496
- Genomics Inform.
- 2012 Jun;10(2):128-132.
- doi: 10.5808/GI.2012.10.2.128
To learn the differences between the structure-activity relationship and molecular vibration-activity relationship in the ligand-receptor interaction of the histamine receptor, 47 ligands of the histamine receptor were analyzed by structural... -
- CITED
-
- Close
- SHARE
-
- Close
- Structure-antimicrobial activity relationship between pleurocidin and its enantiomer
-
Lee JG, Lee D
- KMID: 1094116
- Exp Mol Med.
- 2008 Aug;40(4):370-376.
- doi: 10.3858/emm.2008.40.4.370
To develop novel antibiotic peptides useful as therapeutic drugs, the enantiomeric analogue of pleurocidin (Ple), which is a well known 25-mer antimicrobial peptide, was designed for proteolytic resistance by D-amino... -
- CITED
-
- Close
- SHARE
-
- Close
- Quantitative Structure Activity Relationship between Diazabicyclo[4.2.0]octanes Derivatives and Nicotinic Acetylcholine Receptor Agonists
-
Kim EA, Jung KC, Sohn UD, Im C
- KMID: 2285372
- Korean J Physiol Pharmacol.
- 2009 Feb;13(1):55-59.
- doi: 10.4196/kjpp.2009.13.1.55
Three dimensional quantitative structure activity relationship between diazabicyclo[4.2.0]octanes and nicotinic acetylcholine receptor (h alpha4beta2 and h alpha3beta4) agonists was studied using comparative molecular field analysis (CoMFA) and comparative molecular similarity... -
- CITED
-
- Close
- SHARE
-
- Close
- Pestalotiolide A, a New Antiviral Phthalide Derivative from a Soft Coral-derived Fungus Pestalotiopsis sp.
-
Jia YL, Guan FF, Ma J, Wang CY, Shao CL
- KMID: 2312900
- Nat Prod Sci.
- 2015 Dec;21(4):227-230.
- doi: 10.20307/nps.2015.21.4.227
Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3... -
- CITED
-
- Close
- SHARE
-
- Close
- Cytotoxic Activity and Three-Dimensional Quantitative Structure Activity Relationship of 2-Aryl-1,8-naphthyridin-4-ones
-
Kim YJ, Kim EA, Chung ML, Im C
- KMID: 2285389
- Korean J Physiol Pharmacol.
- 2009 Dec;13(6):511-516.
- doi: 10.4196/kjpp.2009.13.6.511
A series of substituted 2-arylnaphthyridin-4-one analogues, which were previously synthesized in our laboratory, were evaluated for their in vitro cytotoxic activity against human lung cancer A549 and human renal cancer... -
- CITED
-
- Close
- SHARE
-
- Close
- The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity
-
Nam MK, Seong YM, Park HJ, Choi JY, Kang S, Rhim H
- KMID: 1105275
- Exp Mol Med.
- 2006 Feb;38(1):36-43.
Serine protease activity of high temperature requrement 2 (HtrA2) is essential for promoting cell death, as well as for protecting against cellular stresses. An X-ray crystallographic study described the formation... -
- CITED
-
- Close
- SHARE
-
- Close
- Cytotoxic Activity and Quantitative Structure Activity Relationships of Arylpropyl Sulfonamides
-
Hwang YJ, Park SM, Yim CB, Im C
- KMID: 1429304
- Korean J Physiol Pharmacol.
- 2013 Jun;17(3):237-243.
- doi: 10.4196/kjpp.2013.17.3.237
B13 is a ceramide analogue and apoptosis inducer with potent cytotoxic activity. A series of arylpropyl sulfonamide analogues of B13 were evaluated for their cytotoxicity using MTT assays in prostate... -
- CITED
-
- Close
- SHARE
-
- Close
- Development of inhibitors of pyrimidine metabolism
-
Cha S
- KMID: 1105559
- Yonsei Med J.
- 1989 Dec;30(4):315-326.
- doi: 10.3349/ymj.1989.30.4.315
Benzylacyclouridines were developed as specific and potent competitive inhibitors of uridine phosphorylase with Ki values in the nanomolar range. These compounds have no activity against thymidine phosphorylase, uridine kinase,... -
- CITED
-
- Close
- SHARE
-
- Close
- Structure-activity relationships of anti-HIV-1 peptides with disulfide linkage between D- and L-cysteine at positions i and i+3, respectively, derived from HIV-1 gp41 C-peptide
-
Lee MK, Kim HK, Lee TY, Hahm KS, Kim KL
- KMID: 1105273
- Exp Mol Med.
- 2006 Feb;38(1):18-26.
The constrained alpha-helical structure of a C-peptide is useful for enhancing anti-HIV-1 activity. The i and i+3 positions in an alpha-helical structure are located close together, therefore D-Cys (dC) and... -
- CITED
-
- Close
- SHARE
-
- Close
- Study on Receptor-Mediated Catecholamine Activation of Brain Cortical Na-K-ATPase
-
Kim JM, Lee YW
- KMID: 2138524
- J Korean Neurosurg Soc.
- 1985 Jun;14(2):281-292.
In order to examine the properties of catecholic receptor-mediated activation of Na-K-ATPase reaction, author have studied. 1) the structure-activity relationships of various catechol analogues as stimulants of rat cortical Na-K-ATPase.... -
- CITED
-
- Close
- SHARE
-
- Close
- Cytotoxicity and Structure-activity Relationships of Naphthyridine Derivatives in Human Cervical Cancer, Leukemia, and Prostate Cancer
-
Hwang YJ, Chung ML, Sohn UD, Im C
- KMID: 2285479
- Korean J Physiol Pharmacol.
- 2013 Dec;17(6):517-523.
- doi: 10.4196/kjpp.2013.17.6.517
Naphthyridine compounds are important, because they exhibit various biological activities including anticancer, antimicrobial, and anti-inflammatory activity. Some naphthyridines have antimitotic effects or demonstrate anticancer activity by inhibiting topoisomerase II. These... -
- CITED
-
- Close
- SHARE
-
- Close
- Differential Effects of Tautomycetin and Its Derivatives on Protein Phosphatase Inhibition, Immunosuppressive Function and Antitumor Activity
-
Niu M, Sun Y, Liu B, Tang L, Qiu R
- KMID: 2071761
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):145-151.
- doi: 10.4196/kjpp.2012.16.2.145
In the present work, we studied the structure-activity relationship (SAR) of tautomycetin (TMC) and its derivatives. Further, we demonstrated the correlation between the immunosuppressive fuction, anticancer activity and protein phosphatase... -
- CITED
-
- Close
- SHARE
-
- Close
- Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells
-
Kim YJ, Kim EA, Sohn UD, Yim CB, Im C
- KMID: 2071718
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):441-447.
- doi: 10.4196/kjpp.2010.14.6.441
B13, a ceramide analogue, is a ceramidase inhibitor and induces apoptosis to give potent anticancer activity. A series of thiourea B13 analogues was evaluated for their in vitro cytotoxic activities... -
- CITED
-
- Close
- SHARE
-
- Close
- Membrane topology and function of the secretory Na+-K+-2Cl- cotransporter (NKCC1)
-
Gerelsaikhan T, Turner RJ
- KMID: 1026931
- J Korean Med Sci.
- 2000 Aug;15(Suppl):S3-S4.
- doi: 10.3346/jkms.2000.15.S.S3
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Polychlorinated Biphenyls on the Development of Neuronal Cells in Growth Period; Structure-Activity Relationship
-
Do Y, Lee DK
- KMID: 2165388
- Exp Neurobiol.
- 2012 Mar;21(1):30-36.
- doi: 10.5607/en.2012.21.1.30
Polychlorinated biphenyls (PCBs) are accumulated in our body through food chain and cause a variety of adverse health effects including neurotoxicities such as cognitive deficits and motor dysfunction. In particular,... -
- CITED
-
- Close
- SHARE
-
- Close
- Evaluation of Advanced Structure-Based Virtual Screening Methods for Computer-Aided Drug Discovery
-
Lee HS, Choi JW, Yoon SJ
- KMID: 2166251
- Genomics Inform.
- 2007 Mar;5(1):24-29.
Computational virtual screening has become an essential platform of drug discovery for the efficient identification of active candidates. Moleculardocking, a key technology of receptor-centric virtual screening, is commonly used to... -
- CITED
-
- Close
- SHARE
-
- Close
- Structure and Function of a Minimal Receptor Activation Domain of Parathyroid Hormone
-
Lee EJ, Kim HY, Cho MK, Lee W, Lim SK
- KMID: 1734123
- Yonsei Med J.
- 2004 Jun;45(3):419-427.
- doi: 10.3349/ymj.2004.45.3.419
The structure and function of short-length amino terminal PTH analogues were studied. The substitution of Leu7 with Phe in [Ala3, 10Leu7Arg11]rPTH (1-11) NH2 analogue peptides did not show any reduction... -
- CITED
-
- Close
- SHARE
-
- Close
- Expression and Purification of Phospholipase C-beta4, and Chimeric Phospholipase C and Characterization of Them
-
Park DJ
- KMID: 1973790
- Endocrinol Metab.
- 2012 Dec;27(4):282-288.
- doi: 10.3803/EnM.2012.27.4.282
BACKGROUND: Phospholipase C-beta4 (PLC-beta4) is known to be one of the most important signal transducing molecules; however, its biophysical and chemical characteristics are not well known due to the difficulty... -
- CITED
-
- Close
- SHARE
-
- Close
- Chlorination of ortho-position on Polychlorinated Biphenyls Increases Protein Kinase C Activity in Neuronal Cells
-
Lee YJ, Yang JH
- KMID: 1432247
- Toxicol Res.
- 2012 Jun;28(2):107-112.
Polychlorinated biphenyls (PCBs) are persistent and bioaccumulative environmental pollutants. Recently, it is suggested that neurotoxic effects such as motor dysfunction and impairment in memory and learning have been associated with... -
- CITED
-
- Close
- SHARE
-
- Close
- Cytotoxicity and Structure Activity Relationship of Dammarane-Type Triterpenoids from the Bark of Aglaia elliptica against P-388 Murine Leukemia Cells
-
Hidayat AT, Farabi K, Harneti D, Maharani R, Darwati , Nurlelasari , Mayanti T, Setiawan A, Supratman , Shiono Y
- KMID: 2401583
- Nat Prod Sci.
- 2017 Dec;23(4):291-298.
- doi: 10.20307/nps.2017.23.4.291
Six dammarane-type triterpenoids, dammar-24-en-3β-ol (1), 3β-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3β,20-diol (3), dammar-24-en-3β,20-diol (4), 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5), and 3β-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The... -
- CITED
-
- Close
- SHARE
-
- Close
