Genomics Inform.  2012 Jun;10(2):128-132. 10.5808/GI.2012.10.2.128.

Characteristics in Molecular Vibrational Frequency Patterns between Agonists and Antagonists of Histamine Receptors

• Oh SJ

• KMID: 2166496
• DOI: http://doi.org/10.5808/GI.2012.10.2.128

Abstract

To learn the differences between the structure-activity relationship and molecular vibration-activity relationship in the ligand-receptor interaction of the histamine receptor, 47 ligands of the histamine receptor were analyzed by structural similarity and molecular vibrational frequency patterns. The radial tree that was produced by clustering analysis of molecular vibrational frequency patterns shows its potential for the functional classification of histamine receptor ligands.

Keyword

corralled intensity of molecular vibrational frequency; G protein-coupled receptors; histamine receptors; molecular vibration-activity relationship

MeSH Terms

Histamine
Ligands
Receptors, Histamine
Structure-Activity Relationship
Histamine
Ligands
Receptors, Histamine