J Neurogastroenterol Motil.  2017 Jul;23(3):341-348. 10.5056/jnm16203.

Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal

Affiliations
  • 1Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland. jakub.fichna@umed.lodz.pl
  • 2Center of Endoscopy, Starnberg, Germany.
  • 3Walter Brendel Center of Experimental Medicine, Ludwig Maximilians University of Munich, Munich, Germany.

Abstract

Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.

Keyword

Ebastine; Irritable bowel syndrome; Mast cells; Receptors; histamine

MeSH Terms

Gastrointestinal Diseases
Histamine*
Irritable Bowel Syndrome*
Mast Cells
Receptors, Histamine*
Histamine
Receptors, Histamine
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