J Neurogastroenterol Motil.
2017 Jul;23(3):341-348. 10.5056/jnm16203.
Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal
- Affiliations
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- 1Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland. jakub.fichna@umed.lodz.pl
- 2Center of Endoscopy, Starnberg, Germany.
- 3Walter Brendel Center of Experimental Medicine, Ludwig Maximilians University of Munich, Munich, Germany.
- KMID: 2387824
- DOI: http://doi.org/10.5056/jnm16203
Abstract
- Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.
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