- Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal
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Fabisiak A, WÅ‚odarczyk J, Fabisiak N, Storr M, Fichna J
- KMID: 2387824
- J Neurogastroenterol Motil.
- 2017 Jul;23(3):341-348.
- doi: 10.5056/jnm16203
Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis... -
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- Future Treatment of Constipation-associated Disorders: Role of Relamorelin and Other Ghrelin Receptor Agonists
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Mosińska , Zatorski H, Storr M, Fichna J
- KMID: 2433518
- J Neurogastroenterol Motil.
- 2017 Apr;23(2):171-179.
- doi: 10.5056/jnm16183
There is an unmet need for effective pharmacological therapies for constipation, a symptom that significantly deteriorates patients' quality of life and impacts health care. Ghrelin is an endogenous ligand for... -
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- Mast Cells Tryptase Promotes Intestinal Fibrosis in Natural Decellularized Intestinal Scaffolds
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Wan J, Wu T, Liu Y, Yang M, Fichna J, Guo Y, Yin L, Chen C
- KMID: 2533910
- Tissue Eng Regen Med.
- 2022 Aug;19(4):717-726.
- doi: 10.1007/s13770-022-00433-9
BACKGROUND: Standard two-dimensional (2D) culture has confirmed the mechanism of mast cells (MCs) in the pathogenesis of inflammatory bowel disease (IBD), but the regulation of signaling responses of MCs may... -
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