J Korean Neurosurg Soc.  1985 Jun;14(2):281-292.

Study on Receptor-Mediated Catecholamine Activation of Brain Cortical Na-K-ATPase

• Kim JM
• Lee YW

Abstract

In order to examine the properties of catecholic receptor-mediated activation of Na-K-ATPase reaction, author have studied. 1) the structure-activity relationships of various catechol analogues as stimulants of rat cortical Na-K-ATPase. 2) the stereospecificity of alpha and beta-adrenergic agonists on their activation of enzyme system and 3) the relationship of the receptive sites to the enzyme Na-K-ATPase and the effect of EDTA. The observed results were as follows: 1) Noradrenalin, dopamine and isoproterenol stimulated the Na-K-ATPase activity in rat cortical nomogenate. 2) The Na-K-ATPase activation elicited by catecholamines could not be antagonized by beta-receptor blocker, phentolamine and alpha-receptor blocker, propranolol decreased the increase in activity evoked by catecholamine, but it could not inhibit completely. 3) alpha-receptor blocker, phenoxybenzamine inhibited the noradrenalin activation on Na-K-ATPase, and decreased the effect of EDTA on the Na-K-ATPase activity.

Keyword

Na-K-ATPase; Catechol analogues; Adrenergic agonists; Catecholic receptors; EDTA

MeSH Terms

Adrenergic Agonists
Adrenergic beta-Agonists
Animals
Brain*
Catecholamines
Dopamine
Edetic Acid
Isoproterenol
Phenoxybenzamine
Phentolamine
Propranolol
Rats
Structure-Activity Relationship
Adrenergic Agonists
Adrenergic beta-Agonists
Catecholamines
Dopamine
Edetic Acid
Isoproterenol
Phenoxybenzamine
Phentolamine
Propranolol