- Five New Stilbenes from the Stem Bark of Artocarpus communis
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Chan ST, Popplewell WL, Bokesch HR, McKee TC, Gustafson
- KMID: 2432422
- Nat Prod Sci.
- 2018 Dec;24(4):266-271.
- doi: 10.20307/nps.2018.24.4.266
Five new prenylated stilbenes (1 – 5), along with the known compounds cudraflavone C, trans-4-isopentenyl-3,5,2′,4′-terahydroxystilbene, trans-4-(3-methyl-E-but-1-enyl)-3,5,2′,4′-tetrahydroxystilbene, pannokin G, cycloartobiloxanthone, artonin P, morusin, artocarpin, artonin E, kuwanon C, artobiloxanthone, and artoindonesianin... -
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- Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage
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Tjahjandarie TS, Tanjung M, Saputri RD, Nadar PB, Aldin MF, EvaMarliana , Permadi A
- KMID: 2459967
- Nat Prod Sci.
- 2019 Sep;25(3):244-247.
- doi: 10.20307/nps.2019.25.3.244
A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8-isoprenyl-5,7-dihydroxyflavanone (5) were isolated from... -
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- Anti-Helicobacter pylori Compounds from Polygonum cuspidatum
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Khalil AA, Park WS, Kim HJ, Akter KM, Ahn MJ
- KMID: 2355149
- Nat Prod Sci.
- 2016 Sep;22(3):220-224.
- doi: 10.20307/nps.2016.22.3.220
Anti-Helicobacter pylori activity guided fractionation led to the isolation of five anthraquinones, two stilbenes and one naphthoquinone from the EtOAc fraction of Polygonum cuspidatum, using silica gel column chromatography, Sephadex-LH20,... -
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- Potential Role of Sirtuin as a Therapeutic Target for Neurodegenerative Diseases
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Han SH
- KMID: 2045417
- J Clin Neurol.
- 2009 Sep;5(3):120-125.
- doi: 10.3988/jcn.2009.5.3.120
The sirtuins (SIRTs) are protein-modifying enzymes that are distributed ubiquitously in all organisms. SIRT1 is a mammalian homologue of yeast nicotinamide-adenine-dinucleotide-dependent deacetylase silent information regulator 2 (known as Sir2), which... -
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- Sirt1 as a New Therapeutic Target in Metabolic and Age-Related Diseases
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Lee DH
- KMID: 1730001
- Chonnam Med J.
- 2010 Aug;46(2):67-73.
- doi: 10.4068/cmj.2010.46.2.67
Sirt1 among the mammalian sirtuins has generated intense scientific interest in recent years, mainly because of its effects on longevity, metabolism, and other aging-related processes. Via nicotinamide adenine dinucleotide (NAD)-dependent... -
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- Effect of resveratrol on the metastasis of 4T1 mouse breast cancer cells in vitro and in vivo
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Lee HS, Ha AW, Kim WK
- KMID: 2313607
- Nutr Res Pract.
- 2012 Aug;6(4):294-300.
We investigated the effects of resveratrol on metastasis in in vitro and in vivo systems. 4T1 cells were cultured in the presence of various concentrations (0-30 micromol/L) of resveratrol. For... -
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- Effect of Resveratrol on Oral Cancer Cell Invasion Induced by Lysophosphatidic Acid
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Kim JY, Cho KH, Lee HY
- KMID: 2415284
- J Dent Hyg Sci.
- 2018 Jun;18(3):188-193.
- doi: 10.17135/jdhs.2018.18.3.188
The aim of the current study was to demonstrate the potential therapeutic efficacy of resveratrol in oral cancer patients. Lysophosphatidic acid (LPA) intensifies cancer cell invasion and metastasis, whereas resveratrol,... -
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- SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
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Kitada M, Koya D
- KMID: 1965977
- Diabetes Metab J.
- 2013 Oct;37(5):315-325.
- doi: 10.4093/dmj.2013.37.5.315
The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Therefore, a novel therapeutic strategy by which to prevent T2DM is urgently required. Calorie restriction (CR) can retard... -
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- Anti-obesity effect of resveratrol-amplified grape skin extracts on 3T3-L1 adipocytes differentiation
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Zhang XH, Huang B, Choi SK, Seo JS
- KMID: 2313606
- Nutr Res Pract.
- 2012 Aug;6(4):286-293.
Resveratrol (3,4,5-trihydroxy-trans-stilbene), a phytoalexin found in grape skin, grape products, and peanuts as well as red wine, has been reported to have various biological and pharmacological properties. The purpose of... -
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- Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model
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Kwon YJ
- KMID: 2158045
- J Korean Med Sci.
- 2013 Jun;28(6):939-945.
- doi: 10.3346/jkms.2013.28.6.939
This study was done to evaluate whether injections of resveratrol, a natural compound found in the skin of grapes, had anabolic effects on degenerated intervertebral discs in a rabbit model.... -
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- Laxative effect of peanut sprout extract
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Seo JY, Kim SS, Kim HJ, Liu KH, Lee HY, Kim JS
- KMID: 2313678
- Nutr Res Pract.
- 2013 Aug;7(4):262-266.
Certain phenolic compounds are known to exhibit laxative properties. Seed sprouts, such as those of peanut, are known to promote de novo biosynthesis of phenolic compounds. This study was conducted... -
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- Calorie Restriction and Obesity under the Regulation of SIRT1
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Choi IS, Kim KA, Yim JE, Kim YS
- KMID: 2270956
- Korean J Obes.
- 2011 Dec;20(4):170-176.
Obesity is one of the most important risk factors for various chronic diseases, especially related with environmental life style and eating habits. Obesity is also a risk factor of metabolic... -
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- Effects of resveratrol on the insulin signaling pathway of obese mice
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Hong HJ, Kang W, Kim DG, Lee DH, Lee Y, Han CH
- KMID: 1784637
- J Vet Sci.
- 2014 Jun;15(2):179-185.
- doi: 10.4142/jvs.2014.15.2.179
The present study was conducted to investigate the effects of resveratrol on the insulin signaling pathway in the liver of obese mice. To accomplish this, we administered resveratrol to high... -
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- Peanut sprout ethanol extract inhibits the adipocyte proliferation, differentiation, and matrix metalloproteinases activities in mouse fibroblast 3T3-L1 preadipocytes
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Kim WK, Kang NE, Kim MH, Ha AW
- KMID: 2313664
- Nutr Res Pract.
- 2013 Jun;7(3):160-165.
3T3-L1 preadipocyte were differentiated to adipocytes, and then treated with 0, 10, 20, and 40 microg/mL of peanut sprout ethanol extract (PSEE). The main component of PSEE is resveratrol which... -
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- Resveratrol inhibits the protein expression of transcription factors related adipocyte differentiation and the activity of matrix metalloproteinase in mouse fibroblast 3T3-L1 preadipocytes
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Kang NE, Ha AW, Kim JY, Kim WK
- KMID: 2313634
- Nutr Res Pract.
- 2012 Dec;6(6):499-504.
This study attempted to investigate the effects of resveratrol on the differentiation of adipocytes. After cells were treated with various concentrations of resveratrol (0, 10, 20, and 40 micromol/L), adipocyte... -
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- Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity
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Woo A, Min B, Ryoo S
- KMID: 1104212
- Exp Mol Med.
- 2010 Jul;42(7):524-532.
- doi: 10.3858/emm.2010.42.7.053
Arginase competitively inhibits nitric oxide synthase (NOS) via use of the common substrate L-arginine. Arginase II has recently reported as a novel therapeutic target for the treatment of cardiovascular diseases... -
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- Antiproliferative and Cytotoxic Effects of Resveratrol in Mitochondria-Mediated Apoptosis in Rat B103 Neuroblastoma Cells
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Rahman MA, Kim NH, Kim SH, Oh SM, Huh SO
- KMID: 1493964
- Korean J Physiol Pharmacol.
- 2012 Oct;16(5):321-326.
- doi: 10.4196/kjpp.2012.16.5.321
Resveratrol, a natural compound, has been shown to possess anti-cancer, anti-aging, anti-inflammatory, anti-microbial, and neuroprotective activities. In this study, we examined the antiproliferative and cytotoxicity properties of resveratrol in Rat... -
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- Resveratrol Inhibits GABAC rho Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes
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Lee BH, Choi SH, Hwang SH, Kim HJ, Lee JH, Nah SY
- KMID: 1429390
- Korean J Physiol Pharmacol.
- 2013 Apr;17(2):175-180.
- doi: 10.4196/kjpp.2013.17.2.175
Resveratrol is a phytoalexin found in grapes, red wine, and berries. Resveratrol has been known to have many beneficial health effects, such as anti-cancer, neuroprotective, anti-inflammatory, and life-prolonging effects. However,... -
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- AMP-activated protein kinase Activating Agent and Its Implication
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Choi HC
- KMID: 1497647
- Endocrinol Metab.
- 2012 Jun;27(2):109-115.
- doi: 10.3803/EnM.2012.27.2.109
AMP-activated protein kinase (AMPK) is an important cellular fuel sensor. Activation of AMPK requires phosphorylation at threonine (Thr)-172, which resides in the activation loop of the alpha1 and alpha2 subunits.... -
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- Effects of resveratrol on hepatic autophagy in high fat diet-induced obese mice
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Lee HJ, Yang SJ
- KMID: 2327112
- J Nutr Health.
- 2013 Aug;46(4):307-314.
Resveratrol (RSV) exerts several beneficial effects on metabolism and metaflammation-related diseases, including diabetes and non-alcoholic fatty liver disease (NAFLD). The purpose of this study is to investigate whether RSV affects... -
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