- Sphingolipid Mediators of Myocardial Pathology
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Kovilakath A, Cowart LA
- KMID: 2470799
- J Lipid Atheroscler.
- 2020 Jan;9(1):23-49.
- doi: 10.12997/jla.2020.9.1.23
Cardiomyopathy is the leading cause of mortality worldwide. While the causes of cardiomyopathy continue to be elucidated, current evidence suggests that aberrant bioactive lipid signaling plays a crucial role as... -
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- Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology
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Sassa T, Kihara A
- KMID: 2170646
- Biomol Ther.
- 2014 Mar;22(2):83-92.
Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found... -
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- Epidermal Lipid Homeostasis
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Lee SH, Chung HS, Lew W
- KMID: 2383065
- Ann Dermatol.
- 1995 Apr;7(2):99-111.
- doi: 10.5021/ad.1995.7.2.99
Stratum corneum lipids, which are enriched in sphingolipids, free fatty acids, and cholesterol, are required for epidermal barrier function. When the epidermal permeability barrier is perturbed, the transepidermal water loss... -
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- Sphingolipids and Antimicrobial Peptides: Function and Roles in Atopic Dermatitis
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Park K, Lee S, Lee YM
- KMID: 2170669
- Biomol Ther.
- 2013 Jul;21(4):251-257.
Inflammatory skin diseases such as atopic dermatitis (AD) and rosacea were complicated by barrier abrogation and deficiency in innate immunity. The first defender of epidermal innate immune response is the... -
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- The Assessment of the Efficiency of Lipid Extraction by Several Solvents from the Stratum Corneum
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Lee WJ, Kim DW, Jun JB, Chung SL
- KMID: 2230784
- Korean J Dermatol.
- 1995 Oct;33(5):830-840.
BACKGROUND: The efficiency of lipid extraction by different kinds of solvents from stratum corneum may vary. OBJECTIVE: To assess the efficiency of lipid extraction by several solvents from the stratum corneum,... -
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- Altered Levels of Sphingosine and Sphinganine in Psoriatic Epidermis
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Moon SH, Kim JY, Song EH, Shin MK, Cho YH, Kim NI
- KMID: 2265872
- Ann Dermatol.
- 2013 Aug;25(3):321-326.
- doi: 10.5021/ad.2013.25.3.321
BACKGROUND: Ceramides are the main lipid component of the stratum corneum and are a structurally heterogeneous and complex group of sphingolipids of which sphingoid bases are the basic structural constituents.... -
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- Glycosphingolipid Modification: Structural Diversity, Functional and Mechanistic Integration of Diabetes
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Yamashita
- KMID: 2281636
- Diabetes Metab J.
- 2011 Aug;35(4):309-316.
- doi: 10.4093/dmj.2011.35.4.309
Glycosphingolipids (GSLs) are present in all mammalian cell plasma membranes and intracellular membrane structures. They are especially concentrated in plasma membrane lipid domains that are specialized for cell signaling. Plasma... -
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- Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective
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Sidorov E, Sanghera D, Vanamala J
- KMID: 2438648
- J Stroke.
- 2019 Jan;21(1):31-41.
- doi: 10.5853/jos.2018.03454
Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find... -
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- Analysis of ceramide metabolites in differentiating epidermal keratinocytes treated with calcium or vitamin C
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Kim J, Yun H, Cho Y
- KMID: 2313544
- Nutr Res Pract.
- 2011 Oct;5(5):396-403.
Ceramides (Cer) comprise the major constituent of sphingolipids in the epidermis and are known to play diverse roles in the outermost layers of the skin including water retention and provision... -
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- Altered Sphingolipid Metabolism Is Associated With Asthma Phenotype in House Dust Mite-Allergic Patients
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Kowal K, Żebrowska E, Chabowski
- KMID: 2442045
- Allergy Asthma Immunol Res.
- 2019 May;11(3):330-342.
- doi: 10.4168/aair.2019.11.3.330
PURPOSE: Sphingolipids play an important role in cell growth, survival, inflammation and tissue remodeling. House dust mite (HDM) allergy is a major risk factor for asthma. The aim of the... -
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- Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation
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Hong SW, Lee J, Kwon H, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY
- KMID: 2447031
- Endocrinol Metab.
- 2018 Sep;33(3):403-412.
- doi: 10.3803/EnM.2018.33.3.403
BACKGROUND: Emerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current... -
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- Analysis of Lyso-Globotriaosylsphingosine in Dried Blood Spots
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Johnson B, Mascher H, Mascher D, Legnini E, Hung CY, Dajnoki A, Chien YH, Marodi L, Hwu WL, Bodamer OA
- KMID: 1707235
- Ann Lab Med.
- 2013 Jul;33(4):274-278.
- doi: 10.3343/alm.2013.33.4.274
Recently, lyso-globotriaosylsphingosine (lyso-Gb3) was found to be elevated in plasma of treatment naive male patients and some female patients with Fabry Disease (FD). This study tested whether lyso-Gb3 could be... -
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- Anti-apoptotic role of phospholipase D isozymes in the glutamate-induced cell death
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Kim KO, Lee KH, Kim YH, Park SK, Han JS
- KMID: 1088656
- Exp Mol Med.
- 2003 Feb;35(1):38-45.
Abstract Phospholipase D (PLD) plays an important role as an effector in a variety of physiological processes that reveal it to be a member of the signal transducing phospholipases. Recently,... -
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