- Features and Outcomes of Children with Ulcerative Colitis who Undergo a Diagnostic Change: A Single-Center Experience
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Ito N, Takeuchi I, Kyodo R, Hirano Y, Sato T, Usami M, Shimizu H, Shimizu T, Arai K
- KMID: 2518435
- Pediatr Gastroenterol Hepatol Nutr.
- 2021 Jul;24(4):357-365.
- doi: 10.5223/pghn.2021.24.4.357
Purpose: A change in diagnosis from ulcerative colitis (UC) to Crohn's disease (CD) has been reported in pediatric inflammatory bowel disease; however, only a few clinical characteristics and predictors of... -
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- Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis
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Shimizu H, Fujii T, Hibiya S, Motobayashi M, Suzuki K, Takenaka K, Saito E, Nagahori M, Ohtsuka K, Watanabe M
- KMID: 2512107
- Intest Res.
- 2021 Jan;19(1):115-118.
- doi: 10.5217/ir.2020.00030
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- Long-Term Efficacy and Safety of Golimumab for Ulcerative Colitis in a Pediatric Inflammatory Bowel Disease Center in Japan
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Tokita K, Shimizu H, Takeuchi I, Shimizu T, Arai K
- KMID: 2535163
- Pediatr Gastroenterol Hepatol Nutr.
- 2022 Nov;25(6):461-472.
- doi: 10.5223/pghn.2022.25.6.461
Purpose: Golimumab (GLM) is an anti-tumor necrosis factor (TNF)-α antibody preparation known to be less immunogenic than infliximab (IFX) or adalimumab. Few reports on GLM in pediatric patients with ulcerative... -
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- Predictors of Small Bowel Transit Time for Capsule Endoscopy in Children with Inflammatory Bowel Disease
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Oka I, Funayama R, Shimizu H, Takeuchi I, Nojiri S, Shimizu T, Arai K
- KMID: 2544881
- Pediatr Gastroenterol Hepatol Nutr.
- 2023 Jul;26(4):181-192.
- doi: 10.5223/pghn.2023.26.4.181
Purpose: The development of assistive devices has allowed for the performance of capsule endoscopy in children. Anticipating the capsule’s transit time could affect the efficacy of the investigation and potentially... -
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- Long-Term Durability of Infliximab for Pediatric Ulcerative Colitis: A Retrospective Data Review in a Tertiary Children's Hospital in Japan
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Shimizu H, Arai K, Takeuchi I, Minowa K, Hosoi K, Sato M, Oka I, Kaburaki Y, Shimizu T
- KMID: 2510620
- Pediatr Gastroenterol Hepatol Nutr.
- 2021 Jan;24(1):7-18.
- doi: 10.5223/pghn.2021.24.1.7
Purpose: The long-term efficacy and safety of infliximab (IFX) in children with ulcerative colitis (UC) have not been well-evaluated. Here, we reviewed the long-term durability and safety of IFX in... -
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- Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case Report
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Ochi S, Inoue S, Yoshino Y, Shimizu H, Iga JI, Ueno SI
- KMID: 2464726
- Clin Psychopharmacol Neurosci.
- 2019 Nov;17(4):559-563.
- doi: 10.9758/cpn.2019.17.4.559
Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails.... -
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- Stem cell-based therapy for inflammatory bowel disease
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Shimizu H, Suzuki K, Watanabe M, Okamoto R
- KMID: 2454739
- Intest Res.
- 2019 Jul;17(3):311-316.
- doi: 10.5217/ir.2019.00043
Inflammatory bowel disease (IBD) is an idiopathic, multi-etiological disease characterized by inflammation and mucosal destruction of the gastrointestinal tract. Despite the remarkable advance in immunomodulating therapies, there still remains a... -
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- Improvement of Visuo-spatial Function Assessed by Raven’s Colored Progressive Matrices in Dementia with Lewy Bodies by Donepezil Treatment
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Yoshino Y, Mori T, Yoshida T, Toyota Y, Shimizu H, Iga JI, Nishitani , Ueno SI
- KMID: 2388270
- Clin Psychopharmacol Neurosci.
- 2017 Aug;15(3):243-247.
- doi: 10.9758/cpn.2017.15.3.243
OBJECTIVE: Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used... -
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- Phenotypic characteristics of pediatric inflammatory bowel disease in Japan: results from a multicenter registry
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Arai K, Kunisaki R, Kakuta F, Hagiwara Si, Murakoshi T, Yanagi T, Shimizu T, Kato S, Ishige T, Aomatsu T, Inoue M, Saito T, Iwama I, Kawashima H, Kumagai H, Tajiri H, Iwata N, Mochizuki T, Noguchi A, Kashiwabara T, Shimizu H, Suzuki Y, Hirano Y, Fujiwara T
- KMID: 2508568
- Intest Res.
- 2020 Oct;18(4):412-420.
- doi: 10.5217/ir.2019.00130
Background/Aims: There are few published registry studies from Asia on pediatric inflammatory bowel disease (IBD). Registry network data enable comparisons among ethnic groups. This study examined the characteristics of IBD... -
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- Long-term efficacy and safety of tofacitinib in patients with ulcerative colitis: 3-year results from a real-world study
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Shimizu H, Aonuma Y, Hibiya S, Kawamoto A, Takenaka K, Fujii T, Saito E, Nagahori M, Ohtsuka K, Okamoto R
- KMID: 2558196
- Intest Res.
- 2024 Jul;22(3):369-377.
- doi: 10.5217/ir.2023.00194
Background/Aims: The efficacy and safety of tofacitinib for the treatment of refractory ulcerative colitis (UC) has been demonstrated in clinical trials. Although, a series of reports with real-world evidence of... -
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- Clinical outcomes of sigmoid colon volvulus: identification of the factors associated with successful endoscopic detorsion
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Iida T, Nakagaki S, Satoh S, Shimizu H, Kaneto H, Nakase H
- KMID: 2425164
- Intest Res.
- 2017 Apr;15(2):215-220.
- doi: 10.5217/ir.2017.15.2.215
BACKGROUND/AIMS: Although multiple treatment options exist for the management of sigmoid colon volvulus, no study has examined the factors associated with successful endoscopic detorsion. This study aimed to examine the... -
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- Clinical features of very early-onset inflammatory bowel disease in Japan: a retrospective single-center study
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Usami M, Takeuchi I, Kyodo R, Hirano Y, Kashiwagi K, Fujikawa H, Shimizu H, Kawai T, Arai K
- KMID: 2535821
- Intest Res.
- 2022 Oct;20(4):475-481.
- doi: 10.5217/ir.2021.00142
Background/Aims: Very early-onset inflammatory bowel disease (VEO-IBD), defined as IBD diagnosed in patients younger than 6 years, is a challenge for pediatric gastroenterologists. Although there have been reports regarding VEO-IBD... -
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- Combination of leucine-rich alpha-2 glycoprotein and fecal markers detect Crohn’s disease activity confirmed by balloon-assisted enteroscopy
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Kawamoto A, Takenaka K, Hibiya S, Kitazume Y, Shimizu H, Fujii T, Saito E, Ohtsuka K, Okamoto R
- KMID: 2551279
- Intest Res.
- 2024 Jan;22(1):65-74.
- doi: 10.5217/ir.2023.00092
Background/Aims: Endoscopic activity confirmed by enteroscopy is associated with poor clinical outcome in Crohn’s disease (CD). We investigated which of the existing biomarkers best reflects endoscopic activity in CD patients... -
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- Effects of Twice-Daily Injections of Premixed Insulin Analog on Glycemic Control in Type 2 Diabetic Patients
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Shimizu H, Monden T, Matsumura , Domeki N, Kasai K
- KMID: 1779629
- Yonsei Med J.
- 2010 Nov;51(6):845-849.
- doi: 10.3349/ymj.2010.51.6.845
PURPOSE: Premixed insulin is effective to improve glycemic control; however, clinicians may be less likely to know which premixed insulin is appropriate for which patients. This study aimed to evaluate... -
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- Filaggrin Mutation in Korean Patients with Atopic Dermatitis
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On HR, Lee SE, Kim SE, Hong WJ, Kim HJ, Nomura T, Suzuki S, Shimizu H, Kim SC
- KMID: 2427129
- Yonsei Med J.
- 2017 Mar;58(2):395-400.
- doi: 10.3349/ymj.2017.58.2.395
PURPOSE: Atopic dermatitis (AD) is a chronic, relapsing eczematous inflammatory skin disease. Mutations in the filaggrin gene (FLG) are major predisposing factors for AD. Ethnic differences exist between Asian and... -
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- Prognostic factors of synchronous endometrial and ovarian endometrioid carcinoma
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Yoneoka Y, Yoshida H, Ishikawa M, Shimizu H, Uehara T, Murakami T, Kato T
- KMID: 2429576
- J Gynecol Oncol.
- 2019 Jan;30(1):e7.
- doi: 10.3802/jgo.2019.30.e7
OBJECTIVE: Gynecologists occasionally encounter synchronous endometrial and ovarian endometrioid carcinoma (SEO-EC) patients who show favorable prognosis than locally advanced or metastatic disease patients. This study aimed to elucidate prognostic factors... -
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- Treatment strategies for patients with advanced ovarian cancer undergoing neoadjuvant chemotherapy: interval debulking surgery or additional chemotherapy?
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Yoneoka Y, Ishikawa M, Uehara T, Shimizu H, Uno M, Murakami T, Kato T
- KMID: 2457157
- J Gynecol Oncol.
- 2019 Sep;30(5):e81.
- doi: 10.3802/jgo.2019.30.e81
OBJECTIVE: To treat advanced ovarian cancer, interval debulking surgery (IDS) is performed after 3 cycles each of neoadjuvant chemotherapy (NAC) and postoperative chemotherapy (IDS group). If we expect that complete... -
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