Intest Res.  2021 Jan;19(1):115-118. 10.5217/ir.2020.00030.

Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis

Affiliations
  • 1Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
  • 2Department of Endoscopy, Tokyo Medical and Dental University, Tokyo, Japan
  • 3Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
  • 4Institute of Advanced Study, Tokyo Medical and Dental University, Tokyo, Japan


Figure

  • Fig. 1. Efficacy of tofacitinib. (A) Response and remission rates at 4 weeks were 40% and 20%, respectively, and both rates exceeded 40% from 8 to 52 weeks. (B) Responders at 4 weeks had significantly less discontinuation of tofacitinib until 52 weeks.


Reference

1. Ordás I, Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. Ulcerative colitis. Lancet. 2012; 380:1606–1619.
Article
2. Danese S, Grisham M, Hodge J, Telliez JB. JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hub for multiple inflammatory cytokines. Am J Physiol Gastrointest Liver Physiol. 2016; 310:G155–G162.
Article
3. Sandborn WJ, Su C, Sands BE, et al. Tofacitinib as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2017; 376:1723–1736.
Article
4. Sandborn WJ, Panés J, D’Haens GR, et al. Safety of tofacitinib for treatment of ulcerative colitis, based on 4.4 years of data from global clinical trials. Clin Gastroenterol Hepatol. 2019; 17:1541–1550.
Article
5. Suzuki Y, Watanabe M, Matsui T, et al. Tofacitinib as induction and maintenance therapy in Japanese patients with active ulcerative colitis. Inflamm Intest Dis. 2019; 4:131–143.
Article
6. Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005; 353:2462–2476.
Article
7. Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis: a randomized study. N Engl J Med. 1987; 317:1625–1629.
Article
8. D’Haens G, Sandborn WJ, Feagan BG, et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology. 2007; 132:763–786.
Article
9. Lair-Mehiri L, Stefanescu C, Vaysse T, et al. Real-world evidence of tofacitinib effectiveness and safety in patients with refractory ulcerative colitis. Dig Liver Dis. 2020; 52:268–273.
Article
10. Wollenhaupt J, Lee EB, Curtis JR, et al. Safety and efficacy of tofacitinib for up to 9.5years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study. Arthritis Res Ther. 2019; 21:89.
Article
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