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Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity

Shin K, Kim SS, Lee SH, Hong SJ, Choi SJ, Choe JY, Lee SG, Cha HS, Lee EY, Park SH, Hur JW, Na SS, Suh CH, So MW, Choi SW, Sheen DH, Park W, Lee SS, Ryu WH, Kim JS, Song JS, Lee HS, Kim SH, Yoo DH

Background/Aims: The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive...
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Effectiveness and Safety of Tacrolimus in Patients with Active Rheumatoid Arthritis with Inadequate Response to Disease-modifying Anti-rheumatic Drugs: The TREASURE Study

Sheen DH, Hong SJ, Lee SH, Lee HS, Chung WT, Jiang H, Lee S, Yoo DH

OBJECTIVE: Evaluate effectiveness/safety of tacrolimus in patients in Korea with active rheumatoid arthritis (RA) and unsuccessful response to disease-modifying anti-rheumatic drugs (DMARDs). METHODS: Open-label, single-arm, non-comparative, 24-week, Phase-IV study in patients...
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Long-term Treatment with Anti-platelet Agents for Collagen-induced Arthritis Improves Radiological Findings

Kim C, Kim T, Yoo J, Sheen DH, Lee SK, Choi EH, Chun TJ, Kang SW, Shim SC, Lim MK

OBJECTIVES: The objectives of this study were to evaluate the long-term effect of anti-platelet treatment on the radiological progression of collagen-induced arthritis in rats. METHODS: Female Lewis rats with collagen-induced arthritis...
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ADAM33 Polymorphisms Are Associated with Susceptibility to Systemic Lupus Erythematosus in a Korean Population

Kim JY, Kim Y, Chae SC, Lee SS, Lim MK, Sheen DH, Chung HT, Shim SC

OBJECTIVE: The objective of this study is to assess whether genetic functional variants of disintegrin and metalloprotease 33 (ADAM33) are associated with susceptibility to systemic lupus erythematosus (SLE) in a...
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A Case of Guillain-Barre Syndrome in a Patient of Behcet's Disease

Yoo J, Kim NM, Sung W, Myeong JC, Yun SA, Lee DK, Lim MK, Sheen DH

Behcet's disease (BD) is a multi-systemic inflammatory disease of unknown origin that affects nearly all organs including the nervous system. Although the neurological involvement is less frequent than other major...
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Withdrawal: Animal Models in Systemic Lupus Erythematosus

Park H, Sheen DH, Lim MK, Shim SC

This article has been retracted.
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Animal Models in Systemic Lupus Erythematosus

Park H, Sheen DH, Lim MK, Shim SC

Systemic lupus erythematosus (SLE) is an autoimmune disorder affected by multiple genetic, hormonal and environmental factors, which makes it impossible to identify the exact cause of this ailment by only...
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Gene Expression Profile of T-cell Receptors in the Synovium, Peripheral Blood, and Thymus during the Initial Phase of Collagen-induced Arthritis

Kim JY, Lim MK, Sheen DH, Kim C, Lee SY, Park H, Lee MJ, Lee SK, Yang YS, Shim SC

BACKGROUND: Current management strategies attempt to diagnose rheumatoid arthritis (RA) at an early stage. Transcription profiling is applied in the search for biomarkers for detecting early-stage disease. Even though gene...
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A Case of Peritoneal Tuberculosis with Poncet's Disease in a Patient Treated with Infliximab

Park H, Park CW, Kim KB, Lee MJ, Zeon SJ, Shim SC, Lim MK, Sheen DH

Infliximab is a chimeric mouse/human monoclonal antibody against tumor necrosis factor-alpha (TNF-alpha) that is used worldwide to treat rheumatic disease. However, the reactivation of tuberculosis, including extrapulmonary menifestation, is a...
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Association of FOXJ1 polymorphisms with systemic lupus erythematosus and rheumatoid arthritis in Korean population

Li CS, Zhang Q, Lim MK, Sheen DH, Shim SC, Kim JY, Lee SS, Yun KJ, Moon HB, Chung HT, Chae SC

  • KMID: 1091075
  • Exp Mol Med.
  • 2007 Dec;39(6):805-811.
The forkhead-box J1 (FOXJ1) transcription factor could suppress a spontaneous activation of T cells and B cells through an induction of IkappaBbeta that results in repression of NF-kappaB activity. In...
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Successful Treatment of Interstitial Pneumonitis Induced by Leflunomide

Sheen DH, Lim MK, Shim SC, Lee SO, Kang SW, Song JK, Lee YS

Leflunomide is a disease-modifying antirheumatic drug that has been available in Korea since 2003. Leflunomide induced interstitial pneumonitis has been reported as an adverse effect in other countries but not...
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A Case of Idiopathic Thrombocytopenic Purpura in a Patient with Behcet's Disease

Shin HY, Nam HJ, Song JK, Kang SW, Lee SO, Sheen DH, Lim MK, Shim SC

  • KMID: 1585396
  • J Korean Rheum Assoc.
  • 2005 Jun;12(2):137-142.
In Behcet's disease, thrombocytopenia has rarely been reported in association with the hemolytic uremic syndrome, thrombotic thrombocytopenic purpura or in association with cyclosporine or chlorambucil in the treatment of ocular...
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Role of T lymphocyte in the pathogenesis of rheumatoid arthritis

Shim SC, Lim MK, Sheen DH

  • KMID: 2168059
  • Hanyang Med Rev.
  • 2005 May;25(2):26-35.
PURPOSE OF REVIEW: Rheumatoid arthritis (RA) is characterized by a chronic T-cell response that has escaped normal control mechanisms. This review summarizes recent insights in pathways that are functional in...
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Effect of Pulsed Electromagnetic Fields in the Treatment of Knee Osteoarthritis. Report of Double-blind, Placebo-controlled, Randomized Trial

Lee JC, Park JJ, Sheen DH, Choi YM, Park NG, Kim WK, Lee YJ, Lee EB, Song YW

  • KMID: 2334801
  • J Korean Rheum Assoc.
  • 2004 Jun;11(2):143-150.
OBJECTIVE: To determine the effectiveness of pulsed electromagnetic fields (PEMF) in the treatment of knee osteoarthritis (OA). MEHTODS: In this randomized, placebo-controlled, double-blind trial, 51 patients with knee OA, diagnosed...
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Expression of Receptor Activator of NF-kB Ligand (RANKL) and Formation of Osteoclast in Cultured Synovial Fibroblasts

Joo YS, Cheong MA, Sheen DH, Lim MK, Shim SC, Chung DW

  • KMID: 2102027
  • J Korean Rheum Assoc.
  • 2003 Dec;10(4):402-412.
OBJECTIVE: A number of soluble factors,which play important role in the pathophysiology of rheumatoid synovitis are also known to be involved in osteoclast differentiation and activation through RANKL (Receptor activator...
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Sjogren's Syndrome Presenting as Remitting Seronegative Symmetric Synovitis with Pitting Edema(RS3PE)

Choi YM, Sheen DH, Lee YJ, Lee EB, Song YW

Remitting seronegative symmetric synovitis with pitting edema (RS3 PE) syndrome is characterized by symmetrical and acute synovitis, pitting edema, the absence of rheumatoid factor, increased acute phase reactants, lack of...
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Diagnostic Performance of the Antifilaggrin Antibody in Rheumatoid Arthritis

Choi SW, Lim MK, Sheen DH, Ihm CH, Shim SC

  • KMID: 1820201
  • J Lab Med Qual Assur.
  • 2003 Jun;25(1):181-188.
BACKGROUNDS: Rheumatoid factor (RF) is common serological marker for the diagnosis of rheumatoid arthritis (RA), but its sensitivity and specificity are not satisfactory for the diagnosis of RA. Therefore, we...
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Diagnostic Performance of the Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid Arthritis

Choi SW, Lim MK, Sheen DH, Ihm CH, Shim SC

  • KMID: 2305456
  • Korean J Lab Med.
  • 2003 Apr;23(2):132-138.
BACKGROUND: The Rheumatoid Factor (RF) is the only serological marker in the diagnosis of rheumatoid arthritis (RA), but its sensitivity and specificity are not satisfactory for the diagnosis of RA....
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Acute leukemian in patients with juvenile rheumatoid arthritis displaysing multiply osteolytic lesions and compression fracture

Lim MK, Sheen DH, Shim SC

  • KMID: 2080868
  • Korean J Med.
  • 2002 Jul;63(1):103-104.
No abstract available.
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A Case of Appendiceal Mucocele with Concominant Colon Cancer

Yang SS, Lim SH, Song CH, Sheen DH, Lee JY, Han YJ, Lim BC, Kim N, Lee K, Yang DH, Choi SE

  • KMID: 2334213
  • J Korean Soc Coloproctol.
  • 2000 Oct;16(5):346-350.
The appendiceal mucocele is a rare disorder, usually found incidentally during ultrasonography or radiologic studies. Mucoceles of the appendix include benign or malignant disease. Both of benign cystadenoma and malignant...
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