J Korean Rheum Assoc.
2000 Sep;7(3):291-296.
Secondary Amyloidosis Involving Liver in Rheumatoid Arthritis Treated with Methotrexate and Low dose Prednisolone
- Affiliations
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- 1Department of Internal Medicine, Kangnam General Hospital, Public Corporation, Seoul, Korea.
- 2Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
- Amyloidosis is a heterogenous group of often fatal disorders characterized by extracellular deposition of a proteinaceous material with a unique fibrillar form in various tissues and organs. Presenting with severe hepatomegaly, a 46 year-old man who has suffered with rheumatoid arthritis lasting more than 12 years was confirmed to have secondary amyloidosis by liver biopsy. After treatment with methotrexate and low dose prednisolone, we have observed clinical improvement in which hepatomegaly was resolved remarkably. This is the first published case report of a patient with rhuematoid arthritis complicated by liver amyloidosis which partially regressed after treatment with methotrexate and prednisolone.
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