Osong Public Health Res Perspect.  2017 Jun;8(3):179-184. 10.24171/j.phrp.2017.8.3.04.

Long-term Treatment with Anti-platelet Agents for Collagen-induced Arthritis Improves Radiological Findings

Affiliations
  • 1Department of Physiology, Eulji University School of Medicine, Daejeon, Korea.
  • 2Department of Mechanical Engineering, the Cooper Union, New York, NY, USA.
  • 3Division of Rheumatology, Department of Medicine, Eulji University School of Medicine, Daejeon, Korea. mklim@eulji.ac.kr
  • 4Eulji Medi-Bio Research Institute, Eulji University School of Medicine, Daejeon, Korea.
  • 5Department of Radiology, Eulji University School of Medicine, Daejeon, Korea.
  • 6Division of Rheumatology, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea.

Abstract


OBJECTIVES
The objectives of this study were to evaluate the long-term effect of anti-platelet treatment on the radiological progression of collagen-induced arthritis in rats.
METHODS
Female Lewis rats with collagen-induced arthritis were divided into three experimental groups: saline, aspirin monotherapy (n = 12), and aspirin-clopidogrel dual therapy (n = 12). Drugs were administered daily and continued up to 70 days after the induction of arthritis. The clinical arthritis index (weight, morphology score, and paw thickness) and radiological scores were evaluated.
RESULTS
The clinical arthritis index peaked on day 20, while the radiological scores peaked on day 35. No intergroup difference was observed in the clinical arthritis index throughout the experiment. The aspirin-clopidogrel dual therapy group had a significantly higher mean radiological score than the other groups (p = 0.045) on day 35. Further treatments resulted in significantly improved radiological findings in the aspirin monotherapy and aspirin-clopidogrel dual therapy groups on day 70 but no significant improvement in the saline group.
CONCLUSION
Anti-platelet agent treatment improved radiological findings on day 70. These observations emphasize the importance of a future long-term study of the effects of anti-platelet agent treatment on arthritis.

Keyword

antiplatelet drug; collagen induced arthritis; bone erosion; radiological progression

MeSH Terms

Animals
Arthritis
Arthritis, Experimental*
Aspirin
Female
Humans
Rats
Aspirin
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