Korean J Intern Med.  2000 Jan;15(1):32-36.

Difference in the distribution pattern of Helicobacter pylori and grade of gastritis in the antrum and in the body between duodenal ulcer and benign gastric ulcer patients

• Kim N
• Choi WR
• Song CH
• Sheen DH
• Yang SS
• Lee JY
• Han YJ
• Lim SH
• Lee KH
• Choi SE

Abstract

OBJECTIVES
To investigate the relationship between the Helicobacter pylori (H. pylori) colonization and the grade of gastritis in the antrum and in the body of patients with duodenal ulcer (DU) or benign gastric ulcer (BGU). METHODS: This study was performed in H. pylori-positive 220 DU patients and 180 BGU patients. H. pylori density was evaluated by modified Giemsa staining and CLO test, and gastritis grade was graded by H+ACY-E staining in the antrum and in the body. RESULTS: H. pylori grade by Giemsa staining was 1.24 in the antrum and 0.82 in the body for DU group (p +ADw- 0.01), and those of BGU group were slightly reversed, 0.83 and 0.87, respectively, but without statistical significance. Similarly H. pylori grade by CLO test was 3.1 in the antrum and 2.8 in the body for DU group (p +ADw- 0.01), and those of BGU group 2.3 and 2.6 (p +ADw- 0.05), respectively. In contrast, gastritis grade was 1.7 in the antrum and 1.2 in the body for DU group (p +ADw- 0.01), and those of BGU group 1.6 and 1.3 (p +ADw- 0.01), respectively, similar to those of DU. However, there was a correlation between H. pylori grade and gastritis grade in the antrum and in the body, not only in DU but also in BGU group (p +ADw- 0.01). CONCLUSION: In spite of different distribution patterns of H. pylori between DU group and BGU group, gastritis grade of the antrum was significantly higher than that of the body in both DU and BGU. However, gastritis is correlated with H. pylori density not only in DU but also in BGU patients. It looks like the inflammatory reaction to H. pylori is stronger in the antrum than in the body.

Keyword

Helicobacter pylori; Density; Gastritis; Duodenal ulcer; Benign gastric ulcer

MeSH Terms

Adult
Aged
Colony Count, Microbial
Comparative Study
Duodenal Ulcer/pathology+ACo-
Duodenal Ulcer/microbiology
Female
Gastric Fundus/pathology
Gastric Fundus/microbiology
Gastritis/pathology+ACo-
Gastritis/microbiology+ACo-
Helicobacter Infections/pathology
Helicobacter Infections/diagnosis+ACo-
Helicobacter pylori/isolation +ACY- purification+ACo-
Human
Male
Middle Age
Probability
Pyloric Antrum/pathology
Pyloric Antrum/microbiology
Severity of Illness Index
Stomach Ulcer/pathology+ACo-
Stomach Ulcer/microbiology