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Protective Effects of Potassium Ion on Rotenone-Induced Apoptosis in Neuronal (Neuro 2A) Cells

Park JH, Kim YH, Moon SK, Kim TY, Kim JM

  • KMID: 1904919
  • J Korean Neurosurg Soc.
  • 2005 Dec;38(6):456-464.
OBJECTIVE: The authors investigated whether rotenone induces cellular death also in non-dopaminergic neurons and high concentration of potassium ion can show protective effect for non-dopaminergic neuron in case of rotenone-induced...
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Beneficial Effect of Vitamin E in Rotenone Induced Model of PD: Behavioural, Neurochemical and Biochemical Study

Sharma N, Nehru B

Parkinson's disease (PD) a neurodegenerative disorder for which no preventive or long-term effective treatment strategies are available. Epidemiologic studies have failed to identify specific environmental, dietary or lifestyle risk factors...
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Naringin Protects against Rotenone-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells

Kim HJ, Song JY, Park HJ, Park HK, Yun DH, Chung JH

Rotenone, a mitochondrial complex I inhibitor, can induce the pathological features of Parkinson's disease (PD). In the present study, naringin, a grapefruit flavonoid, inhibited rotenone-induced cell death in human neuroblastoma...
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Environmental-Genetic Interactions in the Pathogenesis of Parkinson's Disease

Tsuboi Y

To date, numerous case-control studies have shown the complexity of the pathogenesis of Parkinson's disease (PD). In terms of genetic factors, several susceptibility genes are known to contribute to the...
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Quercetin induces cell death by caspase-dependent and p38 MAPK pathway in EGFR mutant lung cancer cells

Lim EJ, Heo J, Kim YH

OBJECTIVES: The aim of this study was whether quercetin induces cell death by caspase and MAPK signaling pathway in EGFR mutant lung cancer cells. METHODS: PC-9 cells, EGFR mutant lung cancer...
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Treadmill Exercise Improves Motor Function by Suppressing Purkinje Cell Loss in Parkinson Disease Rats

Lee JM, Kim TW, Park SS, Han JH, Shin MS, Lim BV, Kim SH, Baek SS, Cho YS, Kim KH

PURPOSE: Rotenone is the most widely used neurotoxin for the making Parkinson disease (PD) animal model. The neurodegenerative disorder PD shows symptoms, such as slowness of movements, tremor at resting,...
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Effects of Mitochondrial Reactive Oxygen Species on Neuronal Excitability in Rat Spinal Substantia Gelatinosa Neurons

Lee HI, Park AR, Chun SW

  • KMID: 2009495
  • Int J Oral Biol.
  • 2012 Mar;37(1):17-23.
Recent studies indicate that reactive oxygen species (ROS) are critically involved in persistent pain primarily through spinal mechanisms, and that mitochondria are the main source of ROS in the spinal...
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Mechanism of Impaired Endothelium-dependent Vasodilation in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

Chun KJ, Son SM, Kim IJ, Kim CD, Yoo SD, Kim YK

  • KMID: 1569047
  • J Korean Diabetes Assoc.
  • 2002 Feb;26(1):46-56.
BACKGROUND: Impaired vascular endothelium-dependent relaxation and augmented contractile responses have been reported in several long-term animals hyperglycemia models and human diabetic patients. Since oxidative stress has been implicated as...
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Cryptotanshinone inhibits TNF-α-induced LOX-1 expression by suppressing reactive oxygen species (ROS) formation in endothelial cells

Ran X, Zhao W, Li W, Shi J, Chen X

Cryptotanshinone (CPT) is a natural compound isolated from traditional Chinese medicine Salvia miltiorrhiza Bunge. In the present study, the regulatory effect and potential mechanisms of CPT on tumor necrosis factor...
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NADPH Oxidase and Mitochondrial ROS are Involved in the TNF-alpha-induced Vascular Cell Adhesion Molecule-1 and Monocyte Adhesion in Cultured Endothelial Cells

Yu JH, Kim CS, Yoo DG, Song YJ, Joo HK, Kang G, Jo JY, Park JB, Jeon BH

  • KMID: 1587401
  • Korean J Physiol Pharmacol.
  • 2006 Aug;10(4):217-222.
Atherosclerosis is considered as a chronic inflammatory process. However, the nature of the oxidant signaling that regulates monocyte adhesion and its underlying mechanism is poorly understood. We investigated the role...
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Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells

Kim BG, Kwak HB, Choi EY, Kim HS, Kim MH, Kim SH, Choi MK, Chun CH, Oh J, Kim JJ

Among the several rotenoids, amorphigenin is isolated from the leaves of Amopha Fruticosa and it is known that has anti-proliferative effects and anti-cnacer effects in many cell types. The main...
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The Production and Functions of Reactive Oxygen Species in Mouse Bone Marrow-derived Dendritic Cells by Various Haptens and Irritants

Kim DS, Kim DH, Byamba D, Lee TH, Cho YH, Lee MG

  • KMID: 2248021
  • Korean J Dermatol.
  • 2008 Nov;46(11):1470-1477.
BACKGROUND: Various allergens and irritants induced the production of reactive oxygen species (ROS) in the well-established mouse dendritic cell (DC) line XS106 and this production of ROS was inhibited by...
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Inhibitory Effects of 1',2'-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo

Kim KJ, Kwak HB, Choi EY, Oh J, Choi MK, Lee JH, Song MJ, Ahn YH, Lee MS, Lee CH, Park SH, Chae SU, Kim MH, Kim SH, Park KI, Kim KM, Kim HY, Moon SY, Kim JJ

  • KMID: 1449623
  • Korean J Phys Anthropol.
  • 2011 Sep;24(3):165-174.
It is important to identify therapeutic compounds with no adverse effects for use in the chemotherapy of patients with bone-related diseases. The aim of this study was to identify a...
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Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes

Kim NH, Hong BK, Choi SY, Moo Kwon H, Cho CS, Yi EC, Kim WU

  • KMID: 2154251
  • Exp Mol Med.
  • 2013 Jul;45(7):e32.
The activation of nuclear factor of activated T cells 5 (NFAT5), a well-known osmoprotective factor, can be induced by isotonic stimuli, such as activated Toll-like receptors (TLRs). It is unclear,...
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