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Changing the paradigm for cough: does 'cough hypersensitivity' aid our understanding?

Song WJ, Chang YS, Morice AH

Chronic cough is a common reason for patients to seek medication attention. Over the last few decades, we have experienced significant clinical success by applying the paradigm of 'evaluating and...
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A Study of Allergy Skin Tests with Korean Pollen Extracts

Kim YL, Lee SK, Oh SH, Moon BS, Park HS, Hong CS

In Korea, there are two descrite pollen seasons: a tree pollen season and a weed pollen season. In order to investigate the incidence of sensitization to the major pollens and...
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Pathophysiology, Causes and Treatment of Chronic Cough in Adults: Literature Review

Kim H, Sung MW

Chronic cough is a common symptom and the etiology of which can be challenging to diagnose. The key to successful management is to establish a diagnosis and to treat the...
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Skin reactivity and specific IgE antibody to two nonbiting midges in Korean respiratory allergy patients

Kim YJ, Park HS

To evaluate the significance of chironomid as a respiratory allergen, we performed skin prick tests with Chironomus plumosus (CP) and Tokunagayusurika akamusi (TA) extracts on 475 respiratory allergy patients, and...
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Asthma-COPD Overlap Syndrome: What We Know and What We Don't

Sin DD

Approximately one in four patients with chronic obstructive pulmonary disease (COPD) have asthmatic features consisting of wheezing, airway hyper-responsiveness or atopy. The Global initiative for Asthma/Globalinitiative for chronic Obstructive Lung...
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The Interplay between Host Immunity and Respiratory Viral Infection in Asthma Exacerbation

Hossain FM, Choi JY, Uyangaa E, Park SO, Eo SK

Asthma is one of the most common and chronic diseases characterized by multidimensional immune responses along with poor prognosis and severity. The heterogeneous nature of asthma may be attributed to...
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Capsaicin cough sensitivity is related to the older female predominant feature in chronic cough patients

Song WJ, Kim JY, Jo EJ, Lee SE, Kim MH, Yang MS, Kang HR, Park HW, Chang YS, Min KU, Cho SH

PURPOSE: The present study aimed to examine the age and gender distributions among chronic cough patients referred to a tertiary cough clinic in Korea, and to investigate clinical factors related...
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Effect of Interleukin-18 Gene Polymorphisms on Sensitization to Wheat Flour in Bakery Workers

Kim SH, Hur GY, Jin HJ, Choi H, Park HS

Lower respiratory symptoms in bakery workers may be induced by wheat flour and endotoxins. We hypothesized that endotoxins from wheat flour may stimulate innate immunity and that interleukin-18 (IL-18) gene...
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Increased antioxidant activity after exposure of ozone in murine asthma model

Kim YK, Koo SM, Kim K, Uh ST, Jang A, Park CS

BACKGROUND: Ozone is well known as an important component of ambient air pollutants. Ozone can aggravate respiratory symptoms in patients with bronchial asthma, but, not in healthy person. We hypothesized...
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Role of specific IgE, IgG and IgG4 antibodies to corn dust in exposed workers

Park HS, Nahm DH, Kim HY, Suh CH, Kim KS

  • KMID: 759074
  • Korean J Intern Med.
  • 1998 Jul;13(2):88-94.
BACKGROUND AND METHODS: To evaluate the role of specific antibodies to corn dust (CD) and their relationship to respiratory dysfunction, we detected serum specific IgE(slgE) and IgG4(slgG4) antibodies by ELISA...
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Molecular variations in Th1-specific cell surface gene Tim-3

Chae SC, Song JH, Pounsambath P, Yuan HY, Lee JH, Kim JJ, Lee YC, Chung HT

  • KMID: 1097110
  • Exp Mol Med.
  • 2004 Jun;36(3):274-278.
The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of Tim family, Tim-3 (T cell immunoglobulin mucin 3)...
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Specific IgG1 and IgG4 antibodies to citrus red mite in citrus farmers: a study of their relationship to respiratory symptoms

Park HS, Kim HY, Kim YK, Son JW, Nahm DH, Cho SH, Min KU, Kim YY

Citrus red mite (CRM) is known as the most common sensitizing allergen in subjects with asthma and rhinitis working on citrus farms. The aim of this study is to evaluate...
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Additive Effect of Diesel Exhaust Particulates and Ozone on Airway Hyperresponsiveness and Inflammation in a Mouse Model of Asthma

Jang AS, Choi IS, Takizawa H, Rhim TY, Lee JH, Park SW, Park CS

Allergic airway diseases are related to exposure to atmospheric pollutants, which have been suggested to be one factor in the increasing prevalence of asthma. Little is known about the effect...
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Airway Inflammation and Allergen Specific IgE Production May Persist Longer Than Airway Hyperresponsiveness in Mice

Chang YS, Kim YK, Kim TB, Kang HR, Kim SS, Bahn JW, Min KU, Kim YY, Cho SH

During the preclinical study of new therapeutic modality, we evaluate whether the treatment can reverse the established asthma phenotypes in animal model. However, few have reported on the long term...
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Nonspecific Bronchoprovocation Test

Lee MK, Yoon HK, Kim SW, Kim TH, Park SJ, Lee YM

Bronchial asthma is a disease characterized by the condition of airway hyper-responsiveness, which serves to produce narrowing of the airway secondary to airway inflammation and/or various spasm-inducing stimulus. Nonspecific bronchoprovocation...
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Endotoxin Is Not Essential for the Development of Cockroach Induced Allergic Airway Inflammation

Shin YS, Sohn JH, Kim JY, Lee JH, Cho SH, Hong SJ, Lee JS, Hong CS, Park JW

PURPOSE: Cockroach (CR) is an important inhalant allergen and can induce allergic asthma. However, the mechanism by which CR induces airway allergic inflammation and the role of endotoxin in CR...
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Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation

Hur GY, Lee SY, Lee SH, Kim SJ, Lee KJ, Jung JY, Lee EJ, Kang EH, Jung KH, Lee SY, Kim JH, Shin C, Shim JJ, In KH, Kang KH, Yoo SH

  • KMID: 1047088
  • Exp Mol Med.
  • 2007 Jun;39(3):367-375.
The EGFR plays an essential role in goblet cell hyperplasia and mucus hypersecretion. EGFR has an intrinsic tyrosine kinase activity that, when activated, induces the production of MUC5AC through the...
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A Study of Clinical Correlations between Skin Test, Radioallergosorbent Test and Bronchial Provocation Test in House Dust Asthmatics

Hong CS, Hahm KB, Oh SH, Park HS, Huh KB, Kim K

We evaluated the correlations between the allergy skin test for house dust radioallergosorbent test (RAST) and the bronchial provocation test for revealing the sensitivity of the skin test and RAST,...
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Is Performance of a Modified Eucapnic Voluntary Hyperpnea Test in High Ventilation Athletes Reproducible?

Kennedy MD, Steinback , Skow R, Parent EC

PURPOSE: Exercise-induced bronchoconstriction (EIB) is common in “high ventilation” athletes, and the Eucapnic Voluntary Hyperpnea (EVH) airway provocation test is the standard EIB screen. Although the EVH test is widely...
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Relationship between serum IgA level and allergy/asthma

Kim WJ, Choi IS, Kim CS, Lee JH, Kang HW

BACKGROUND/AIMS: Mucosal immunoglobulin A (IgA) may prevent the entrance of allergens. This study examined the relationship between serum IgA levels (within the normal range) and sensitization to house dust mites...
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