- Detection of Familial Hypercholesterolemia Using Next Generation Sequencing in Two Population-Based Cohorts
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Kim HN, Kweon SS, Shin MH
- KMID: 2458582
- Chonnam Med J.
- 2018 Jan;54(1):31-35.
- doi: 10.4068/cmj.2018.54.1.31
We aimed to evaluate the prevalence of familial hypercholesterolaemia (FH) in a subject with hypercholesterolaemia from two population-based cohorts in South Korea. A total of 283 subjects with total cholesterol... -
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- The Role of Vitamin D in Menopausal Medicine
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Kim M, Kim TH, Lee HH, Kim HY, Oh MJ
- KMID: 2365234
- Kosin Med J.
- 2016 Dec;31(2):97-102.
- doi: 10.7180/kmj.2016.31.2.97
Menopause is the time at which menstruation stops in women. After menopause, women are more susceptible to some diseases, especially osteoporosis and cardiovascular disease. Vitamin D has a protective effect... -
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- Analysis of low - density - lipoprotein receptor gene in Korean patients with familial hypercholesterolemia
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Kim HS, Chae IH, Park YB, Choe SC, Han KH, Chae JJ, Kim SH
- KMID: 2143091
- Korean J Med.
- 1999 Nov;57(5):881-895.
Familial hypercholesterolemia (FH) is a common autosomal dominant disorder caused by a defect in the low-density-lipoprotein (LDL) receptor, disrupting the normal control of cholesterol metabolism. We have collected 86 FH families for... -
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- The usefulness of the genetic markers at the low-density lipoprotein receptor gene locus for the genetic diagnosis of familial hypercholesterolemia
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Choi BJ, Park HY, Kim GY, Nm SM, Cho SY, Jang YS
- KMID: 1985204
- Korean J Med.
- 2000 Mar;58(3):283-292.
BACKGROUND: Familial hypercholesterolemia(FH) is an autosomal dominant metabolic disorder caused by the mutation in low density lipoprotein receptor(LDLR) gene. However, direct genetic diagnosis of LDLR gene mutation is not easily available because... -
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- Genome-wide association study of degenerative mitral valve disease in Maltese dogs
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Lee CM, Song DW, Ro WB, Kang MH, Park HM
- KMID: 2434779
- J Vet Sci.
- 2019 Jan;20(1):63-71.
- doi: 10.4142/jvs.2019.20.1.63
Genome-wide association study (GWAS) is a powerful tool for identifying the genetic causes of various diseases. This study was conducted to identify genomic variation in Maltese dog genomes associated with... -
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- A Critical Role of PCSK9 in Mediating IL-17-Producing T Cell Responses in Hyperlipidemia
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Kim YU, Kee P, Danila D, Teng BB
- KMID: 2466611
- Immune Netw.
- 2019 Dec;19(6):e41.
- doi: 10.4110/in.2019.19.e41
We previously demonstrated that atherogenic Ldlr(−/−)Apobec1(−/−) (LDb) double knockout mice lacking both low-density lipoprotein receptor (LDLR) and apolipoprotein B mRNA-editing catalytic polypeptide-1 (Apobec1) had increased serum IL-17 levels, with T... -
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- Kimchi attenuates fatty streak formation in the aorta of low-density lipoprotein receptor knockout mice via inhibition of endoplasmic reticulum stress and apoptosis
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Woo M, Kim M, Noh JS, Park CH, Song YO
- KMID: 2395298
- Nutr Res Pract.
- 2017 Dec;11(6):445-451.
- doi: 10.4162/nrp.2017.11.6.445
BACKGROUND/OBJECTIVES: Endoplasmic reticulum (ER) stress is positively associated with atherosclerosis via elevating macrophage cell death and plaque formation, in which oxidative stress plays a pivotal role. Antioxidative, lipid-lowering, and anti-atherogenic... -
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- Corn silk extract improves cholesterol metabolism in C57BL/6J mouse fed high-fat diets
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Cha JH, Kim SR, Kang HJ, Kim MH, Ha AW, Kim WK
- KMID: 2434084
- Nutr Res Pract.
- 2016 Oct;10(5):501-506.
- doi: 10.4162/nrp.2016.10.5.501
BACKGROUND/OBJECTIVES: Corn silk (CS) extract contains large amounts of maysin, which is a major flavonoid in CS. However, studies regarding the effect of CS extract on cholesterol metabolism is limited.... -
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- Topology of Scavenger Receptor Class B Type I (SR-BI) on Brush Border Membrane
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Han CH, Lee MH
- KMID: 1097342
- J Vet Sci.
- 2002 Dec;3(4):265-272.
Both hydropathy plot and in vitro translation results predict the topology of SR-BI; the receptor is an integral membrane protein of 509 amino acids, consisting of a short cytoplasmic N-terminus... -
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