- Effects of Isoflavones Supplemented Diet on Lipid Concentrations and Hepatic LDL Receptor mRNA Level in Growing Female Rats
-
Choi MJ, Jo HJ
- KMID: 2269838
- Korean J Nutr.
- 2005 Jun;38(5):344-351.
The purpose of this study was to examine the impact of isoflavones on lipid concentrations and hepatic LDL receptor mRNA level in growing female rats. Twenty four rats (body weight... -
- CITED
-
- Close
- SHARE
-
- Close
- Intertriginous Xanthoma in an Infant with Familial Hypercholesterolemia
-
Kim YU, Lee SW, Kim KJ, Heo EP
- KMID: 2246371
- Korean J Dermatol.
- 2014 Mar;52(3):178-181.
Familial hypercholesterolemia is an autosomal dominant inherited metabolic disease characterized by high serum low-density lipoprotein (LDL) cholesterol concentrations, and xanthoma formation. There are multiple types of xanthomas, such as eruptive,... -
- CITED
-
- Close
- SHARE
-
- Close
- Expression of low density lipoprotein receptors in lymphoblasts induced by anti-CD3 antibody in patients with hypercholesterolemia
-
Shin BM, Park YB, Kim JQ
- KMID: 644896
- J Korean Med Sci.
- 1995 Oct;10(5):318-323.
- doi: 10.3346/jkms.1995.10.5.318
Familial hypercholesterolemia(FH) is a disease based on defects of low-density lipoprotein receptors(LDL-R). To interrupt and control the natural course of this disease, early identification of these patients is important. The... -
- CITED
-
- Close
- SHARE
-
- Close
- Ubiquitin Ligases in Cholesterol Metabolism
-
Jiang W, Song BL
- KMID: 2280686
- Diabetes Metab J.
- 2014 Jun;38(3):171-180.
- doi: 10.4093/dmj.2014.38.3.171
To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players... -
- CITED
-
- Close
- SHARE
-
- Close
- New Drugs for Treating Dyslipidemia: Beyond Statins
-
Ahn CH, Choi SH
- KMID: 1805891
- Diabetes Metab J.
- 2015 Apr;39(2):87-94.
- doi: 10.4093/dmj.2015.39.2.87
Statins have been shown to be very effective and safe in numerous randomized clinical trials, and became the implacable first-line treatment against atherogenic dyslipidemia. However, even with optimal statin treatment,... -
- CITED
-
- Close
- SHARE
-
- Close
- Recent Advances in 'Human Rhinovirus and Allergy' Research
-
- KMID: 2146018
- Korean J Asthma Allergy Clin Immunol.
- 2010 Jun;30(2):86-90.
Human rhinovirus (HRV) is a positive-sense single-stranded small RNA virus (7.2 kbp) in the Picornaviridae family and the genus Enterovirus. The complete genome sequences have recently been analyzed. Phylogeny shows... -
- CITED
-
- Close
- SHARE
-
- Close
- Evaluation of Lipids According to Apo E Genotype in Normal Control and Hyperlipidemic Patients
-
Kim HT, Park MJ, Lee KM
- KMID: 2287738
- J Clin Pathol Qual Control.
- 1999 Dec;21(2):265-273.
BACKGROUND: Apolipoprotein E (Apo E) plays a central role in the hepatic clearance of Apo E rich lipoprotein (VLDL, chylomicron remnant, intermediate density lipoprotein) through LDL receptor. Apo E is... -
- CITED
-
- Close
- SHARE
-
- Close
- In silico Screening of Chemical Libraries to Develop Inhibitors That Hamper the Interaction of PCSK9 with the LDL Receptor
-
Min DK, Lee HS, Lee N, Lee CJ, Song HJ, Yang GE, Yoon D, Park SW
- KMID: 2163616
- Yonsei Med J.
- 2015 Sep;56(5):1251-1257.
- doi: 10.3349/ymj.2015.56.5.1251
PURPOSE: Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low density lipoprotein receptor (LDLR) and promotes degradation of the LDLR. Inhibition of PCSK9 either by reducing its expression or... -
- CITED
-
- Close
- SHARE
-
- Close
- Analysis of low - density - lipoprotein receptor gene in Korean patients with familial hypercholesterolemia
-
Kim HS, Chae IH, Park YB, Choe SC, Han KH, Chae JJ, Kim SH
- KMID: 2143091
- Korean J Med.
- 1999 Nov;57(5):881-895.
Familial hypercholesterolemia (FH) is a common autosomal dominant disorder caused by a defect in the low-density-lipoprotein (LDL) receptor, disrupting the normal control of cholesterol metabolism. We have collected 86 FH families for... -
- CITED
-
- Close
- SHARE
-
- Close
- Statin and the risk of new-onset diabetes mellitus
-
Kim SH
- KMID: 2395597
- J Korean Med Assoc.
- 2017 Nov;60(11):901-911.
- doi: 10.5124/jkma.2017.60.11.901
Statins are the first choice of pharmacological treatment for dyslipidemia to prevent atherosclerotic cardiovascular disease. Ample evidence demonstrates the benefits and safety of statin, including the lipid-lowering efficacy and the... -
- CITED
-
- Close
- SHARE
-
- Close
- Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro
-
Kim JW, Kang KW, Oh GT, Song J, Kim ND, Pak YK
- KMID: 1081463
- Exp Mol Med.
- 2002 May;34(2):137-144.
Cholesterol-rich diet impairs endothelial NO synthase (eNOS) and enhances inducible NOS (iNOS) expression. In this study, we investigated effects of cholesterol on iNOS expression in high-fat-fed rat models, HepG2 and... -
- CITED
-
- Close
- SHARE
-
- Close
- KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model
-
Choi JH, Yoo JY, Kim SO, Yoo SE, Oh GT
- KMID: 1402317
- Exp Mol Med.
- 2012 Dec;44(12):733-739.
KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemia-reperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H2O2-induced reactive... -
- CITED
-
- Close
- SHARE
-
- Close
- Polymorphism Study of Susceptibility Genes Related to Sporadic Alzheimer's Disease
-
Choi YS, Lee KS, Park YG, Kim SH
- KMID: 2338467
- J Korean Geriatr Soc.
- 2006 Jun;10(2):115-124.
Background: We investigated whether any single nucleotide polymorphism of the 7 candidate susceptibility genes is associated with sporadic Alzheimer's disease (AD). Methods: Genomic DNA from brain tissues of registered cases of... -
- CITED
-
- Close
- SHARE
-
- Close
- Association between Bone Mineral Density and LDL Receptor-Related Protein 5 Gene Polymorphisms in Young Korean Men
-
Koh JM, Jung MH, Hong JS, Park HJ, Chang JS, Shin HD, Kim SY, Kim GS
- KMID: 1786820
- J Korean Med Sci.
- 2004 Jun;19(3):407-412.
- doi: 10.3346/jkms.2004.19.3.407
Recently, It has been reported that the LDL receptor-related protein 5 (LRP5) regulates bone formation, and that mutations of the gene cause osteoporosis-pseudoglioma syndrome or high bone mass phenotypes. However,... -
- CITED
-
- Close
- SHARE
-
- Close
- Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome
-
Bae KH, Kim SW, Choi YK, Seo JB, Kim N, Kim CY, Lee WK, Lee S, Kim JG, Lee IK, Lee JH, Park KG
- KMID: 2413983
- Diabetes Metab J.
- 2018 Jun;42(3):207-214.
- doi: 10.4093/dmj.2017.0081
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor. PCSK9 has emerged as a target for lipid-lowering therapy, but... -
- CITED
-
- Close
- SHARE
-
- Close
- Sterol-independent repression of low density lipoprotein receptor promoter by peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1alpha)
-
Jeong JH, Cho S, Kim Pak Y
- KMID: 756233
- Exp Mol Med.
- 2009 Jun;41(6):406-416.
- doi: 10.3858/emm.2009.41.6.046
Peroxisome proliferator activated receptor (PPAR) gamma coactivator-1alpha (PGC-1alpha) may be implicated in cholesterol metabolism since PGC-1alpha co-activates estrogen receptor alpha (ERalpha) transactivity and estrogen/ERalpha induces the transcription of LDL receptor... -
- CITED
-
- Close
- SHARE
-
- Close
- Circadian regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6
-
Lee YJ, Han DH, Pak YK, Cho S
- KMID: 1401756
- Exp Mol Med.
- 2012 Nov;44(11):642-652.
Low density lipoprotein receptor (LDLR) plays an important role in the cholesterol homeostasis. We examined the possible circadian regulation of LDLR and mechanism(s) underlying it. In mice, blood glucose and... -
- CITED
-
- Close
- SHARE
-
- Close
- Metabolites profiling and hypolipidemic/hypocholesterolemic effects of persimmon (Diosyros kaki Thumb.) by different processing procedures: in vitro and in vivo studies
-
Park SY, Oh EK, Lim Y, Shin JY, Jung HA, Park SY, Lee JH, Choe JS, Kwon O
- KMID: 2419498
- J Nutr Health.
- 2018 Aug;51(4):275-286.
- doi: 10.4163/jnh.2018.51.4.275
PURPOSE: Our previous study demonstrated that persimmon (Diospyros kaki Thumb.) at different stages of ripening provided different protective effects against high-fat/cholesterol diet (HFD)-induced dyslipidemia in rats. In this study, we... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice
-
Nam KH, Choi JH, Seo YJ, Lee YM, Won YS, Lee MR, Lee MN, Park JG, Kim YM, Kim HC, Lee CH, Lee HK, Oh SR, Oh GT
- KMID: 1110129
- Exp Mol Med.
- 2006 Aug;38(4):445-452.
We investigated the effect of tilianin upon inducible nitric oxide synthesis in the plasma of low-density lipoprotein receptor knock-out (Ldlr-/-) mice fed with high cholesterol diet and in primary peritoneal... -
- CITED
-
- Close
- SHARE
-
- Close
- 5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesion
-
Choi JH, Park JG, Jeon HJ, Kim MS, Lee MR, Lee MN, Sonn S, Kim JH, Lee MH, Choi MS, Park YB, Kwon OS, Jeong TS, Lee WS, Shim HB, Shin DH, Oh GT
- KMID: 1022122
- Exp Mol Med.
- 2011 Aug;43(8):471-478.
- doi: 10.3858/emm.2011.43.8.053
A variety of benzylidenethiazole analogs have been demonstrated to inhibit 5-lipoxygenase (5-LOX). Here we report the anti-atherogenic potential of 5-(4-hydroxy-2,3,5-trimethylbenzylidene) thiazolidin-2,4-dione (HMB-TZD), a benzylidenethiazole analog, and its potential mechanism of... -
- CITED
-
- Close
- SHARE
-
- Close
