J Clin Pathol Qual Control.  1999 Dec;21(2):265-273.

Evaluation of Lipids According to Apo E Genotype in Normal Control and Hyperlipidemic Patients

• Kim HT
• Park MJ
• Lee KM

Abstract

BACKGROUND: Apolipoprotein E (Apo E) plays a central role in the hepatic clearance of Apo E rich lipoprotein (VLDL, chylomicron remnant, intermediate density lipoprotein) through LDL receptor. Apo E is present as three major isoforms, named Apo E2, E3, and E4. Apo E genotype is one of determinants of the serum triglyceride and cholesterol level due to their different binding affinity for LDL receptor, and highly variable among different populations.
METHODS
This study was undertaken to evaluation of plasma lipids depending on the Apo E genotype in 15 normal and 35 hyperlipidemic people by INNO-LiPA Apo kit.
RESULTS
The frequency of Apo E were epsilon3 0.857, epsilon2 0.071, and epsilon4 0.071, that did not different statistically from control group epsilon3 0.933 epsilon 0.033, epsilon4 0.033 (P>0.05). Serum concentration of Lp(a) in Apo E 3/2 group was significantly higher than in Apo E3/3 group of hyperlipidemic patients (P<0.05). Apo E3/2 genotype were observed in hypertriglyceridemic group. So epsilon2 allele was associated with a higher serum triglyceride and Lp(a) concentration.
CONCLUSIONS
It seems that epsilon2 allele plays an important role in triglyceride and Lp(a) concentration.

MeSH Terms

Alleles
Apolipoprotein E2
Apolipoproteins
Apolipoproteins E*
Cholesterol
Chylomicron Remnants
Genotype*
Humans
Hyperlipidemias
Lipoproteins
Plasma
Protein Isoforms
Receptors, LDL
Triglycerides
Apolipoprotein E2
Apolipoproteins
Apolipoproteins E
Cholesterol
Chylomicron Remnants
Lipoproteins
Protein Isoforms
Receptors, LDL