Korean Circ J.  1996 Aug;26(4):813-821. 10.4070/kcj.1996.26.4.813.

Correlation between Apolipoprotein E Polymorphism and Plasma Lipid Levels in the Korean Males

• Ryu JC
• Kim DK
• Kim JW
• Kim SW
• Park WH
• Choo JA
• Choi YR
• Joo SB
• Gwon HC
• Park SW
• Kim JS
• Lee SH
• Hong KP
• Kim DW
• Park JE
• Lee WR

• KMID: 2229018
• DOI: http://doi.org/10.4070/kcj.1996.26.4.813

Abstract

BACKGROUND
Apo E lipoprotein is made up of 299 amino acid and is classified into three major isoforms(E2, E3 and E4). Aop E lipoprotein plays an important role in the regulation of the lipid metabolism. The purpose of this study is to evaluate the variations of plasma lipids depending on the apo E genotype in the Korean males.
METHODS
We studied 257 male subjects without evidence of coronary artery disease. Apo E genotyping was determined with the INNO-line probe assay apo E test, which is based on reverse hybridization.
RESULTS
Apo E genotype frequencies for 257 subjects were as follows, 73.9% for epsilon3/3, 16% for epsilon4/3, 8.2% for epsilon3/2, 1.2% for epsilon2/2, and 0.8 for epsilon4/4. We found significant differences in apo E allele frequencies of our subjects campared with those of western populations. Compared to the subjects with apo epsilon3, the subjects with apo epsilon2 was associated with higher levels of triglyceride, and the subjects with apo epsilon4 had lower levels of HDL cholesterol.
CONCLUSION
The frequencies of apeE genotype varies depending on the ethnic origin. ApoE polymorphism plays an important role in determining individual differences in plasma lipids.

Keyword

Apo E polymorphism; Genotyping; Lipid

MeSH Terms

Apolipoproteins E
Apolipoproteins*
Cholesterol, HDL
Coronary Artery Disease
Gene Frequency
Genotype
Hominidae
Humans
Individuality
Lipid Metabolism
Lipoproteins
Male*
Plasma*
Triglycerides
Apolipoproteins
Apolipoproteins E
Cholesterol, HDL
Lipoproteins