Korean J Med.  2005 May;68(5):511-518.

Apolipoprotein E and ACE genetic polymorphism and nephropathy in type 2 diabetic patients

• Park JS
• Nam JY
• Kim CS
• Kim DM
• Cho MH
• Park J
• Ahn CW
• Cha BS
• Lim SK
• Kim KR
• Lee HC

Abstract

BACKGROUND: The aim of this study was to investigate the association between apo E and ACE genetic polymorphism and diabetic nephropathy.
METHODS
One hundred eighteen patients with type 2 diabetes who had a duration of diabetes longer than 8 years were divided into the three apo E groups (E2, E3, E4) and three ACE groups (II, ID, DD). Plasma levels of lipids were measured. The frequency of diabetic nephropathy and clinical and biochemical characteristics were compared among the Apo E and ACE genotype groups.
RESULTS
The frequency of overt nephropathy was significantly greater in apo E2 patients with diabetes (46.7%) than apo E3 (16.7%) or apo E4 patients (10.5%). Logistical regression analysis showed that odds ratio of apo E2 and apo E4 genotypes for the presence of overt nephropathy were 4.779 (p<0.01) and 0.643 (p=0.583), respectively. Plasma TG levels were significantly greater in apo E2 patients. This study did not show an association between ACE gene polymorphism and diabetic nephropathy, and no interaction between Apo E and ACE gene polymorphism.
CONCLUSION
Apo E2 is a prognostic risk factor for diabetic nephropathy in Korean type 2 diabetes. TG may have an important role of diabetic nephropathy. There were not synergistic effect between Apo E and ACE gene polymorphism in diabetic nephropathy.

Keyword

Apolipoprotein E (Apo E) gene; Angiotensin-converting enzyme (ACE) gene; Type 2 diabetes; Diabetic nephropathy

MeSH Terms

Apolipoprotein E2
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E
Apolipoproteins*
Diabetic Nephropathies
Genotype
Humans
Odds Ratio
Plasma
Polymorphism, Genetic*
Risk Factors
Apolipoprotein E2
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins
Apolipoproteins E