- Immunohistochemical Expression of CXC Chemokine Receptor 4 and Galectin-3 in Follicular Tumors of Thyroid
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Park JE, Kim BK, Gwoo S, Park YH, Choi YS, Kim YO
- KMID: 2198435
- J Korean Thyroid Assoc.
- 2012 May;5(1):45-51.
- doi: 10.11106/jkta.2012.5.1.45
BACKGROUND AND OBJECTIVES: Follicular tumors can present a difficult diagnostic challenge for cytological evaluation and ultrasound findings. Therefore, new methods which could help distinguish follicular adenoma from follicular carcinoma simply... -
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- Silencing of CXCR4 Inhibits Tumor Cell Proliferation and Neural Invasion in Human Hilar Cholangiocarcinoma
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Tan XY, Chang S, Liu W, Tang HH
- KMID: 1774548
- Gut Liver.
- 2014 Mar;8(2):196-204.
BACKGROUND/AIMS: To evaluate the expression of CXC motif chemokine receptor 4 (CXCR4) in the tissues of patients with hilar cholangiocarcinoma (hilar-CCA) and to investigate the cell proliferation and frequency of... -
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- Meta-Analysis of the Relationship between CXCR4 Expression and Metastasis in Prostate Cancer
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Lee JY, Kang DH, Chung DY, Kwon JK, Lee H, Cho NH, Choi YD, Hong SJ, Cho KS
- KMID: 2320781
- World J Mens Health.
- 2014 Dec;32(3):167-175.
- doi: 10.5534/wjmh.2014.32.3.167
PURPOSE: Experimental studies have suggested that the stromal-derived factor-1 (SDF-1)/CXCR4 axis is associated with tumor aggressiveness and metastasis in several malignancies. We performed a meta-analysis to elucidate the relationship between... -
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- Targeting the CXCL12/CXCR4 axis in acute myeloid leukemia: from bench to bedside
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Cho BS, Kim HJ, Konopleva
- KMID: 2371646
- Korean J Intern Med.
- 2017 Mar;32(2):248-257.
- doi: 10.3904/kjim.2016.244
The interactions between the cancerous cells of acute myeloid leukemia (AML) and the bone marrow (BM) microenvironment have been postulated to be important for resistance to chemotherapy and disease relapse... -
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- Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer
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Kim DI, Kim E, Kim YA, Cho SW, Lim JA, Park YJ
- KMID: 2352988
- Endocrinol Metab.
- 2016 Sep;31(3):469-475.
- doi: 10.3803/EnM.2016.31.3.469
BACKGROUND: Tumor associated macrophages (TAMs) and CXC chemokine receptor 4 (CXCR4) have emerged as potential biomarkers in various human cancers. The aims of this study were to investigate the clinical... -
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- Production of Stromal Cell-Derived Factor-1 (SDF-1)and Expression of CXCR4 in Human Bone Marrow Endothelial Cells
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Yun HJ, Jo DY
- KMID: 1130038
- J Korean Med Sci.
- 2003 Oct;18(5):679-685.
- doi: 10.3346/jkms.2003.18.5.679
This study investigated the production of stromal cell-derived factor-1 (SDF-1) and the expression of CXCR4 in human bone marrow endothelial cells (BMECs). Human BMEC cell line BMEC-1 cells expressed SDF-1... -
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- Differential effects of CXCR4 antagonists on the survival and proliferation of myeloid leukemia cells in vitro
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Kim HY, Hwang JY, Oh YS, Kim SW, Lee HJ, Yun HJ, Kim S, Yang YJ, Jo DY
- KMID: 2251985
- Korean J Hematol.
- 2011 Dec;46(4):244-252.
- doi: 10.5045/kjh.2011.46.4.244
BACKGROUND: Antagonists of CXC chemokine receptor 4 (CXCR4), including AMD3100, induce peripheral mobilization of hematopoietic stem cells and have been approved for clinical use. We explored whether the CXCR4 antagonists... -
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- RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 Gene Polymorphisms are not Associated with the Outcome of Hepatitis B Virus Infection: Results from a Large Scale Single Ethnic Population
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Cheong JY, Cho SW, Choi JY, Lee JA, Kim MH, Lee JE, Hahm KB, Kim JH
- KMID: 1778366
- J Korean Med Sci.
- 2007 Jun;22(3):529-535.
- doi: 10.3346/jkms.2007.22.3.529
Recovery from hepatitis B virus (HBV) infection depends on the cellular immune responses. Chemokines and their receptors play significant roles in immune defense. This study was undertaken to investigate the... -
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- Cardioprotective Effect of the SDF-1α/CXCR4 Axis in Ischemic Postconditioning in Isolated Rat Hearts
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Kim JS, Jang Y, Kim JH, Park YH, Hwang SA, Kim J, Lee SR, Xu Z, Ban C, Ahn K, Chun KJ
- KMID: 2396488
- Korean Circ J.
- 2017 Nov;47(6):949-959.
- doi: 10.4070/kcj.2016.0353
BACKGROUND AND OBJECTIVES: Information about the role of the stromal cell-derived factor-1α (SDF-1α)/chemokine receptor type 4 (CXCR4) axis in ischemic postconditioning (IPOC) is currently limited. We hypothesized that the SDF-1α/CXCR4... -
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- LPS-Induced Migration of Peritoneal B-1 Cells is Associated with Upregulation of CXCR4 and Increased Migratory Sensitivity to CXCL12
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Moon H, Lee JG, Shin SH, Kim TJ
- KMID: 1792975
- J Korean Med Sci.
- 2012 Jan;27(1):27-35.
- doi: 10.3346/jkms.2012.27.1.27
B-1 cells, which constitute a predominant lymphocyte subset in serosal cavities and produce most of natural antibodies, are subdivided into the CD5+ B-1a and CD5- B-1b cell subpopulations, but the... -
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- Clinical significance of nuclear factor kappaB and chemokine receptor CXCR4 expression in patients with diffuse large B-cell lymphoma who received rituximab-based therapy
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Shin HC, Seo J, Kang BW, Moon JH, Chae YS, Lee SJ, Lee YJ, Han S, Seo SK, Kim JG, Sohn SK, Park TI
- KMID: 2070136
- Korean J Intern Med.
- 2014 Nov;29(6):785-792.
- doi: 10.3904/kjim.2014.29.6.785
BACKGROUND/AIMS: This study investigated the expression of nuclear factor kappaB (NF-kappaB) and the chemokine receptor (CXCR4) in patients with diffuse large B-cell lymphoma (DLBCL) who received rituximab-based therapy. METHODS: Seventy patients... -
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- Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosis
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Song JS, Kang CM, Kang HH, Yoon HK, Kim YK, Kim KH, Moon HS, Park SH
- KMID: 1078362
- Exp Mol Med.
- 2010 Jun;42(6):465-476.
- doi: 10.3858/emm.2010.42.6.048
CXC chemokine receptor 4 (CXCR4), which binds the stromal cell-derived factor-1 (SDF-1), has been shown to play a critical role in mobilizing the bone marrow (BM)-derived stem cells and inflammatory... -
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- Stem Cells Expressing Homing Receptors Could be Expanded From Cryopreserved and Unselected Cord Blood
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Lee YH, Han JY, Seo SY, Kim KH, Lee YA, Lee YS, Lee HS, Hur WJ, Han H, Kwon HC, Kim JS, Kim HJ
- KMID: 1733500
- J Korean Med Sci.
- 2004 Oct;19(5):635-639.
- doi: 10.3346/jkms.2004.19.5.635
We assessed the cytokine combinations that are best for ex vivo expansion of cord blood (CB) and the increment for cell numbers of nucleated cells, as well as stem cells... -
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- Homing-Associated Cell Adhesion Molecules and Cell Cycle Status on the Nucleated Cells in the Bone Marrow, Mobilized Peripheral Blood and Cord Blood
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Lee YH, Lee YA, Noh KT, Kim KH, Han JY, Seo SY, Kwon HC, Kim JS, Kim HJ
- KMID: 2157680
- J Korean Med Sci.
- 2004 Aug;19(4):523-528.
- doi: 10.3346/jkms.2004.19.4.523
Homing-associated cell adhesion molecules (H-CAM) on the CD34+ cells play an important role for the engraftment process following hematopoietic stem cell transplantation (HSCT). However, it seems that not only CD34+... -
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- The Result of Anterior Interbody Fusion on Low Back Problem
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Kang JS, Kim NH
- KMID: 2445981
- J Korean Orthop Assoc.
- 1986 Feb;21(1):47-56.
- doi: 10.4055/jkoa.1986.21.1.47
Low back pain and sciatica is one of the most frequent and troublesome problem in the orthopedic field. A study of the effectivity and reliability of the anterior interbody fusion... -
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- Effect of Endogenous Bone Marrow Derived Stem Cells Induced by AMD-3100 on Expanded Ischemic Flap
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Jeong HS, Lee HK, Tark KC, Lew DH, Koh YW, Kim CH, Seo IS
- KMID: 2151419
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S237-S248.
- doi: 10.3346/jkms.2014.29.S3.S237
The purpose of this study was to devise an expanded ischemic flap model and to investigate the role of AMD-3100 (Plerixafor, chemokine receptor 4 inhibitor) in this model by confirming... -
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- Contralaterally transplanted human embryonic stem cell-derived neural precursor cells (ENStem-A) migrate and improve brain functions in stroke-damaged rats
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Chang DJ, Oh SH, Lee N, Choi C, Jeon I, Kim HS, Shin DA, Lee SE, Kim D, Song J
- KMID: 2154272
- Exp Mol Med.
- 2013 Nov;45(11):e53.
The transplantation of neural precursor cells (NPCs) is known to be a promising approach to ameliorating behavioral deficits after stroke in a rodent model of middle cerebral artery occlusion (MCAo).... -
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