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Red Blood Cell Enzymopathies Causing Hereditary Hemolytic Anemia

Hah JO

  • KMID: 1441716
  • Clin Pediatr Hematol Oncol.
  • 2012 Apr;19(1):1-6.
The RBC enzyme deficiencies causing hereditary hemolytic anemia (HHA) can be divided into three groups: those participating in the glycolytic (E-M) pathway; those involved with the maintenance of a high...
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Hereditary Hemolytic Anemia

Hah JO

The hereditary hemolytic anemia (HHA) can be classified into three types according to the pathogenesis: RBC membrane defects, hemoglobinopathies, and RBC enzymopathies. Clinical characteristics of these three types of HHA...
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RBC Enzyme Analysis

Song J

  • KMID: 2049286
  • Clin Pediatr Hematol Oncol.
  • 2013 Apr;20(1):8-12.
Among ~20 RBC enzyme deficiencies causing hereditary hemolytic anemia (HRA), deficiencies involving three RBC enzymes such as glucose-6-phosphatase, pyruvate kinase and pyrimidine 5'-nucleodiase were known to be relatively common. The...
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Profiling of Proteins Regulated by Venlafaxine during Neural Differentiation of Human Cells

Doh MS, Han DM, Oh DH, Kim SH, Choi MR, Chai YG

OBJECTIVE: Antidepressants are known to positively influence several factors in patients with depressive disorders, resulting in increased neurogenesis and subsequent relief of depressive disorders. To study the effects of venlafaxine...
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Hemolytic anemia in pediatrics

Hah JO

To understand the hemolytic anemia (HA) in children, the diagnostic approach and management of hereditary and acquired HA are described. The hereditary hemolytic anemia (HHA) can be classified according to...
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The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test

Kim YC, Kim JH, Cheung DY, Kim TH, Jun EJ, Oh JW, Kim CW, Chung WC, Kim BW, Kim SS, Kim JI, Park SH, Kim JK

BACKGROUND/AIMS: M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK)...
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Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro

Yuan S, Qiao T, Zhuang X, Chen W, Xing N, Zhang Q

PURPOSE: The aim of our study was to explore the relationships between the M2 isoform of pyruvate kinase (PKM2) and the sensitivity of human non-small cell lung cancer (NSCLC) cells...
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Usefulness of Plasma Tumor M2-Pyruvate Kinase in the Diagnosis of Gastrointestinal Cancer

Kim CW, Kim JI, Park SH, Han JY, Kim JK, Chung KW, Sun HS

  • KMID: 1112189
  • Korean J Gastroenterol.
  • 2003 Nov;42(5):387-393.
BACKGROUND/AIMS: Pyruvate kinase (PK) is a key enzyme of glycolysis. Different isoforms of this enzyme are tissue-specifically expressed (M2-PK, M1-PK, R-PK, L-PK). The concentration of the dimeric M2-PK is...
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Difference of Gene Expression between Hypertrophic Scar Keratinocytes and Normal Keratinocytes

Choi SW, Chung HY, Lim YK, Kim HN, Oh JW, Kim MK, Jeon SH, Hong YT

  • KMID: 2203029
  • J Korean Soc Plast Reconstr Surg.
  • 2010 Jul;37(4):317-322.
PURPOSE: There is no clear evidence of the original cause of hypertrophic scar, and the effective method of treatment is not yet established. Recently the steps of searching in gene...
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Enzymatic method for assaying calcium in serum with Ca++-ATPase

Javed HM, Michelangeli F

  • KMID: 1088653
  • Exp Mol Med.
  • 2003 Feb;35(1):17-22.
A kinetic assay for total calcium in serum was developed which is based on the activation of Ca++-ATPase by free Ca++ [Ca++]f maintained by EGTA in the reaction mixture. The...
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Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo

Tang JC, An R, Jiang YQ, Yang J

PURPOSE: The purpose of this study was to observe the effects of metformin on human esophageal cancer cell and to investigate its possible mechanisms. MATERIALS AND METHODS: Cell viability was detected...
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Proteomic Analysis of Penile Protein Alterations in a Rat Model of Cavernous Nerve Injury

Chung H, Lee CK, Kim B, Kim HS, Kim TW, Paick SH, Jeon HS, Yang SK

  • KMID: 2311850
  • Korean J Urol.
  • 2009 May;50(5):498-504.
PURPOSE: Cavernous nerve resection (CNR) in rats is a standard model of animal experiments on erectile dysfunction (ED) that occurs after radical prostatectomy (RP). Injured cavernous nerves after surgery can...
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Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells

Song H, Yoon SP, Kim J

After renal injury, selective damage occurs in the proximal tubules as a result of inhibition of glycolysis. The molecular mechanism of damage is not known. Poly(ADP-ribose) polymerase (PARP) activation plays...
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Potential biomarkers and antagonists for fluoranthene-induced cellular toxicity of bone marrow derived mesenchymal stem cells

Hoque MM, Lee YE, Kim HR, Shin MG

BACKGROUND: Fluoranthene (FR) is a common environmental pollutant that exists in a complex mixture with other polycyclic aromatic hydrocarbons (PAHs). We identified biomarkers for monitoring FR exposure and investigated the...
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Hereditary Hemolytic Anemia in Korea: a Retrospective Study from 1997 to 2006

Cho HS, Hah JO, Kang IJ, Kang HJ, Kwak JY, Koo HH, Kook H, Kim BK, Kim SK, Kim ST, Kim YD, Kim JY, Kim CS, Ghim T, Kim HS, Park SG, Park SY, Park JE, Bang SM, Seo JJ, Suh CI, Sohn SK, Shin HJ, Shin HY, Ahn HS, Oh D, Yoo ES, Lyu CJ, Yoon SS, Lee KS, Lee KC, Lee KH, Lee SY, Lee YH, Lee JA, Lee JS, Lim YT, Lim JY, Im HJ, Jeong DC, Chong SY, Chung JS, Jung HL, Cho GJ, Jo DY, Jin JY, Choi EJ, Hyun MS, Hwang PH

BACKGROUND: The aim of this study was to investigate the prevalence, clinical and laboratory findings of hereditary hemolytic anemia (HHA) in Korea from 1997 to 2006 and to develop the...
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