- Pathogenesis and Management of Serrated Polyps: Current Status and Future Directions
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Anderson J
- KMID: 2070073
- Gut Liver.
- 2014 Nov;8(6):582-589.
- doi: 10.5009/gnl14248
Hyperplastic or serrated polyps were once believed to have little to no clinical significance. A subset of these polyps are now considered to be precursors to colorectal cancers (CRC) in... -
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- Regulation of bcl-2 family in hydrogen peroxide-induced apoptosis in human leukemia HL-60 cells
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Lee JE, Sohn JW, Lee JH, Lee KC, Son CS, Tockgo YC
- KMID: 927133
- Exp Mol Med.
- 2000 Mar;32(1):42-46.
Numerous types of cells have been shown to undergo apoptosis when exposed to oxidant agent such as hydrogen peroxide. In order to understand the functional relationship between the anti- and... -
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- Pim-1: A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis
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Wang Z, Bhattacharya N, Weaver M, Petersen K, Meyer M, Gapter L, Magnuson N
- KMID: 1119212
- J Vet Sci.
- 2001 Dec;2(3):167-179.
Pim-1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice,... -
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- Phylogenetically interrelated ETS genes, ETV1, ERM and E1A-F locate on different chromosomes
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Jeon IS, Shapiro DN
- KMID: 1038161
- J Korean Med Sci.
- 1998 Aug;13(4):355-360.
- doi: 10.3346/jkms.1998.13.4.355
ETV1, ERM and E1A-F are members of the multigene ETS domain containing a class of transcription factors, first identified in the genome of the avian retrovirus E26. Based upon... -
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- Menin represses JunD transcriptional activity in protein kinase Ctheta-mediated Nur77 expression
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Kim H, Lee JE, Kim BY, Cho EJ, Kim ST, Youn HD
- KMID: 1089456
- Exp Mol Med.
- 2005 Oct;37(5):466-475.
TCR signaling leading to thymocyte apoptosis is mediated through the expression of the Nur77 family of orphan nuclear receptors. It has been shown that the Nur77 promoter is activated by... -
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- ROS1 Expression in Invasive Ductal Carcinoma of the Breast Related to Proliferation Activity
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Eom M, Lkhagvadorj S, Oh SS, Han A, Park KH
- KMID: 1727878
- Yonsei Med J.
- 2013 May;54(3):650-657.
- doi: 10.3349/ymj.2013.54.3.650
PURPOSE: ROS1 is an oncogene, expressed primarily in glioblastomas of the brain that has been hypothesized to mediate the effects of early stage tumor progression. In addition, it was reported... -
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- Multiple Endocrine Neoplasia Type 1 Presenting as Hypoglycemia due to Insulinoma
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Kwon EB, Jeong HR, Shim YS, Lee HS, Hwang JS
- KMID: 2373713
- J Korean Med Sci.
- 2016 Jun;31(6):1003-1006.
- doi: 10.3346/jkms.2016.31.6.1003
Multiple endocrine neoplasia (MEN) mutation is an autosomal dominant disorder characterized by the occurrence of parathyroid, pancreatic islet, and anterior pituitary tumors. The incidence of insulinoma in MEN is relatively... -
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- Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells
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Park HW, Song JY, Kim KS, Han Y, Kim CW, Yi SY, Yun YS
- KMID: 1123762
- Exp Mol Med.
- 2004 Oct;36(5):411-419.
Ceramide generated from sphingomyelin in response to ionizing radiation has been implicated as a second messenger to induce cellular proapoptotic signals. Both ceramide and its metabolic inhibitor, N, N-dimethyl-D-erythro-sphingosine (DMS),... -
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- A Case of Multiple Endocrine Neoplasia Type 1 Combined with Papillary Thyroid Carcinoma
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Kim HJ, Park JS, Kim CS, Kang ES, Cha BS, Lim SK, Kim KR, Lee HC, Ahn CW
- KMID: 724269
- Yonsei Med J.
- 2008 Jun;49(3):503-506.
- doi: 10.3349/ymj.2008.49.3.503
This is the first report of papillary thyroid carcinoma combined with multiple endocrine neoplasia type 1 (MEN1) in Korea. MEN1 is a hereditary disease comprising neoplastic disorders such as pituitary,... -
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- Ectopic Over-expression of Oncogene Pim-2 Induce Malignant Transformation of Nontumorous Human Liver Cell Line L02
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Ren K, Duan W, Shi Y, Li B, Liu Z, Gong J
- KMID: 1792950
- J Korean Med Sci.
- 2010 Jul;25(7):1017-1023.
- doi: 10.3346/jkms.2010.25.7.1017
In order to prove that ectopic over-expression of Pim-2 could induce malignant transformation of human liver cell line L02, three groups of cells were set up including human liver cell... -
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- Enhanced induction of Bax gene expression in H460 and H1299 cells with the combined treatment of cisplatin and adenovirus mediated wt-p53 gene transfer
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Choi JH, Ahn KS, Kim JG, Hong YS
- KMID: 927130
- Exp Mol Med.
- 2000 Mar;32(1):23-28.
Cytotoxic effect of either cisplatin or p53 gene transfection of lung cancer cells may be different depending on the p53 status of cells. We investigated cytotoxic effects on the combined... -
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- The relationship between cisplatin-induced apoptosis and p53, bcl-2 and bax expression in human lung cancer cells
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Han JY, Chung YJ, Park SW, Kim JS, Rhyu MG, Kim HK, Lee KS
- KMID: 759083
- Korean J Intern Med.
- 1999 Jan;14(1):42-52.
OBJECTIVES: Given the roles of bcl-2, bax and p53 in apoptosis, we investigated the effect of their expression on the response to cisplatin in order to understand the... -
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- A Novel Mutation (C67Y) in the NOTCH3 Gene in a Korean CADASIL Patient
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Na DL, Moon SY, Kim HY, Seok JI, Kwon JC, Ki CS, Kim JW, Suh YL
- KMID: 1099812
- J Korean Med Sci.
- 2003 Feb;18(1):141-144.
- doi: 10.3346/jkms.2003.18.1.141
We report a 52-yr-old Korean woman with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) whose diagnosis was confirmed by skin biopsy and the presence of a novel... -
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- A Rare Case of Primary Hyperparathyroidism Associated with Primary Aldosteronism, Hurthle Cell Thyroid Cancer and Meningioma
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Kim YL, Jang YW, Kim JT, Sung SA, Lee TS, Lee WM, Kim HJ
- KMID: 1372802
- J Korean Med Sci.
- 2012 May;27(5):560-564.
- doi: 10.3346/jkms.2012.27.5.560
Multiple endocrine neoplasia type 1 (MEN1) syndrome includes varying combinations of endocrine and non-endocrine tumors. There are also a considerable number of atypical MEN1 syndrome. In this case, a 68-yr-old... -
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- B cell-associated immune profiles in patients with end-stage renal disease (ESRD)
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Kim KW, Chung BH, Jeon EJ, Kim BM, Choi BS, Park CW, Kim YS, Cho SG, Cho ML, Yang CW
- KMID: 1387357
- Exp Mol Med.
- 2012 Aug;44(8):465-472.
Most of the previous studies on immune dysregulation in end-stage renal disease (ESRD) have focused on T cell immunity. We investigated B cell subpopulations in ESRD patients and the effect... -
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