J Vet Sci.  2001 Dec;2(3):167-179.

Pim-1: A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis

• Wang Z
• Bhattacharya N
• Weaver M
• Petersen K
• Meyer M
• Gapter L
• Magnuson N

Abstract

Pim-1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice, Pim-1 kinase is involved in the control of cell growth, differentiation and apoptosis. Expression of Pim-1 kinase can be stimulated by a variety of growth factors and regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational. Several signal transduction pathways may be associated with the regulation of Pim-1's expression; accumulating data support that the expression of Pim-1 protein is mediated through activation of JAK/STATs. Recent studies of Pim family kinases indicate that Pim-1 kinase plays important roles outside of the hematopoietic system as well.

MeSH Terms

Animals
Apoptosis/*physiology
Cell Differentiation/physiology
Cell Division/*physiology
*Cell Transformation, Neoplastic
Gene Expression Regulation, Enzymologic
Humans
Lymphoma/etiology
Mice
Protein-Serine-Threonine Kinases/genetics/*physiology
Proto-Oncogene Proteins/genetics/*physiology
Proto-Oncogene Proteins c-pim-1
Signal Transduction