J Korean Med Sci.  1998 Aug;13(4):355-360. 10.3346/jkms.1998.13.4.355.

Phylogenetically interrelated ETS genes, ETV1, ERM and E1A-F locate on different chromosomes

• Jeon IS
• Shapiro DN

• KMID: 1038161
• DOI: http://doi.org/10.3346/jkms.1998.13.4.355

Abstract

ETV1, ERM and E1A-F are members of the multigene ETS domain containing a class of transcription factors, first identified in the genome of the avian retrovirus E26. Based upon extensive homology between these genes within their ETS domain (96% identity each other), these three genes comprise a distinct sub-family of ETS genes as a human PEA3 sub-family. By analyzing somatic cell hybrid segregating human chromosomes, the genes encoding ETV1, ERM and E1A-F were localized to human chromosome 7, 3 and 17, respectively. Fluorescence in situ hybridization confirmed these assignments and allowed mapping of the genes to 7p22 (ETV1), 3q29 (ERM) and 17q12 (E1A-F). These results suggest the ancestral PEA3 gene may have duplicated first, then dispersed to other chromosomal locations.

MeSH Terms

Adenovirus E1A Proteins/genetics*
Animal
Chromosome Mapping
Chromosomes, Human, Pair 17*
Chromosomes, Human, Pair 3*
Chromosomes, Human, Pair 7*
DNA-Binding Proteins/genetics*
Human
Hybrid Cells
In Situ Hybridization, Fluorescence
Multigene Family
Phylogeny
Proto-Oncogene Proteins/genetics*
Rodentia
Transcription Factors/genetics*