- Pim-1: A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis
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Wang Z, Bhattacharya N, Weaver M, Petersen K, Meyer M, Gapter L, Magnuson N
- KMID: 1119212
- J Vet Sci.
- 2001 Dec;2(3):167-179.
Pim-1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice,... -
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- Molecules and their functions in autophagy
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Pyo JO, Nah J, Jung YK
- KMID: 1120125
- Exp Mol Med.
- 2012 Feb;44(2):73-80.
- doi: 10.3858/emm.2012.44.2.029
Autophagy is a self-degradation system of cellular components through an autophagosomal-lysosomal pathway. Over the last 15 yr, yeast genetic screens led to the identification of a number of genes involved... -
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- A Case of Crohn's Disease Accompanied by Peutz-Jeghers Syndrome
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Um YJ, Kim SM, Pyo JS, Lee JA, Koo HS, Huh KC
- KMID: 1792744
- Korean J Gastroenterol.
- 2013 Oct;62(4):243-247.
- doi: 10.4166/kjg.2013.62.4.243
Peutz-Jeghers syndrome is an autosomal dominant inherited disorder characterized by multiple gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. Peutz-Jeghers syndrome has an incidence of approximately 1 in 25,000 to 300,000 births.... -
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- Cyclooxygenase 2 in Gastric Carcinoma Is Expressed in Doublecortin- and CaM Kinase-Like-1-Positive Tuft Cells
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Mutoh H, Sashikawa , Sakamoto H, Tateno T
- KMID: 2070061
- Gut Liver.
- 2014 Sep;8(5):508-518.
- doi: 10.5009/gnl13237
BACKGROUND/AIMS: Doublecortin and CaM kinase-like-1 (DCAMKL1) is a marker of stem cells expressed predominantly in the crypt base in the intestine. However, DCAMKL1-positive cells have been shown to be differentiated... -
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- Suppression of Aurora-A oncogenic potential by c-Myc downregulation
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Yang S, He S, Zhou X, Liu M, Zhu H, Wang Y, Zhang W, Yan S, Quan L, Bai J, Xu N
- KMID: 994399
- Exp Mol Med.
- 2010 Nov;42(11):759-767.
- doi: 10.3858/emm.2010.42.11.077
The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how... -
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- p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest
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Chae HD, Kim SY, Park SE, Kim J, Shin DY
- KMID: 1245266
- Exp Mol Med.
- 2012 Mar;44(3):236-240.
- doi: 10.3858/emm.2012.44.3.018
We previously reported that the p53 tumor suppressor protein plays an essential role in the induction of tetraploid G1 arrest in response to perturbation of the actin cytoskeleton, termed actin... -
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- Ectopic Over-expression of Oncogene Pim-2 Induce Malignant Transformation of Nontumorous Human Liver Cell Line L02
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Ren K, Duan W, Shi Y, Li B, Liu Z, Gong J
- KMID: 1792950
- J Korean Med Sci.
- 2010 Jul;25(7):1017-1023.
- doi: 10.3346/jkms.2010.25.7.1017
In order to prove that ectopic over-expression of Pim-2 could induce malignant transformation of human liver cell line L02, three groups of cells were set up including human liver cell... -
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- Cross-talk between BubR1 expression and the commitment to differentiate in adipose-derived mesenchymal stem cells
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Lee J, Lee CG, Lee KW, Lee CW
- KMID: 1099864
- Exp Mol Med.
- 2009 Dec;41(12):873-879.
- doi: 10.3858/emm.2009.41.12.093
BubR1 mitotic checkpoint kinase monitors attachment of microtubules to kinetochores and links regulation of the chromosome-spindle attachment to mitotic checkpoint signaling. Defects in BubR1-mediated signaling severely perturb checkpoint control and... -
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- Molecular and Clinical Characteristics of Myotonic Dystrophy Type 1 in Koreans
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Kim SY, Kim JY, Kim GP, Sung JJ, Lim KS, Lee KW, Chae JH, Hong YH, Seong MW, Park SS
- KMID: 1781584
- Korean J Lab Med.
- 2008 Dec;28(6):483-492.
- doi: 10.3343/kjlm.2008.28.6.483
BACKGROUND: Myotonic dystrophy type 1 (DM1) is an autosomal-dominant muscular dystrophy caused by expansion of cytosine-thymine-guanine (CTG) trinucleotide repeats in the myotonic dystrophy protein kinase (DMPK) gene. The clinical features... -
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