- Identification of a Novel Putative Protein Serine / Threonine Kinase, PK38, in Normal Human Keratinocytes
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Gil MC, Ha HJ
- KMID: 1548220
- Korean J Immunol.
- 1997 Jun;19(2):189-196.
No abstract available. -
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- Action Mechanisms of Hormone Binding to Cell Surface Receptors: 3) TGF-beta; Binding to Serine-threonine Kinase Receptors and Action Mechanisms
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Hahm KB
- KMID: 2199641
- J Korean Soc Endocrinol.
- 2000 Jun;15(3):353-366.
No Abstract Available. -
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- Pim-1: A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis
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Wang Z, Bhattacharya N, Weaver M, Petersen K, Meyer M, Gapter L, Magnuson N
- KMID: 1119212
- J Vet Sci.
- 2001 Dec;2(3):167-179.
Pim-1 belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice,... -
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- WNKs: protein kinases with a unique kinase domain
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Huang CL, Cha SK, Wang HR, Xie J, Cobb MH
- KMID: 1090959
- Exp Mol Med.
- 2007 Oct;39(5):565-573.
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in... -
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- Peutz-Jeghers syndrome with germline mutation of STK11
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Chae HD, Jeon CH
- KMID: 2167111
- Ann Surg Treat Res.
- 2014 Jun;86(6):325-330.
- doi: 10.4174/astr.2014.86.6.325
Peutz-Jeghers syndrome (PJS), also known as periorificial lentiginosis, is a rare autosomal dominant inherited disease with an incidence of 1/200,000 live-borns. Mutations in the serine-threonine kinase 11 (STK11) gene are... -
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- IMMUNOHISTOCHEMICAL STUDY OF AURORA-2 KINASE IN THE ORAL SQUAMOUS CELL CARCINOMA
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Han SJ, Kim SW, Kim KW
- KMID: 2058671
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2010 Mar;32(2):112-117.
Aurora kinases represent a novel family of serine/threonine kinases crucial for cell cycle control. Aurora-2 kinase is mainly involved in centrosome function, mitotic entry, and spindle assembly. Aurora-2 kinase overexpression... -
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- Association between Serine/Threonine Kinase 39 Gene Polymorphism, Hypertension, and Other Cardiovascular Risk Factors in Koreans
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Shin DJ, Lee SH, Park S, Jang Y
- KMID: 1722996
- Korean Circ J.
- 2013 Jan;43(1):13-22.
- doi: 10.4070/kcj.2013.43.1.13
BACKGROUND AND OBJECTIVES: Although the association between single nucleotide polymorphisms (SNPs) of Serine/Threonine Kinase 39 (STK39) and hypertension has been reported, the prior studies have been inconsistent. The aim of... -
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- RNA Mapping of Mutant Myotonic Dystrophy Protein Kinase 3'-Untranslated Region Transcripts
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Song MS, Lee SW
- KMID: 2166464
- Genomics Inform.
- 2009 Dec;7(4):181-186.
Myotonic dystrophy type 1 (DM1), which is a dominantly inherited neurodegenerative disorder, results from a CTG trinucleotide repeat expansion in the 3'-untranslated region (3'-UTR) of the myotonic dystrophy protein kinase... -
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- Neuroprotection by 1,25(OH)2-Vitamin D3 Against Kainic Acid-Induced Excitotoxicity in the Rat Hippocampus
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Choi JY, Lee KS, Kim YI
- KMID: 1572457
- J Korean Neurol Assoc.
- 2006 Jun;24(3):245-251.
BACKGROUND: The neuroprotective effects of 1,25-dihydroxyvitamin D3 on neurotoxicity have already been documented. However, the mechanisms underlying these effects are not fully understood. Extracellular signal-regulated kinase (ERK), one of the... -
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- Screening of Differentially Expressed Genes between PC12 Cells and A123.7 Cells
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Baik SY, Chai YG, Yang BH
- KMID: 2334593
- J Korean Soc Biol Psychiatry.
- 1999 Jul;6(1):67-73.
The cAMP-dependent protein kinase(PKA) is an intracellular enzyme with serine-threonine kinase activity that plays a key role in cell growth, differentiation, and apoptosis in eukaryotes. In order to understand the... -
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- A Case of Crohn's Disease Accompanied by Peutz-Jeghers Syndrome
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Um YJ, Kim SM, Pyo JS, Lee JA, Koo HS, Huh KC
- KMID: 1792744
- Korean J Gastroenterol.
- 2013 Oct;62(4):243-247.
- doi: 10.4166/kjg.2013.62.4.243
Peutz-Jeghers syndrome is an autosomal dominant inherited disorder characterized by multiple gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. Peutz-Jeghers syndrome has an incidence of approximately 1 in 25,000 to 300,000 births.... -
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- Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
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Jeoung NH, Harris RA
- KMID: 2029884
- Korean Diabetes J.
- 2010 Oct;34(5):274-283.
- doi: 10.4093/kdj.2010.34.5.274
In the well-fed state a relatively high activity of the pyruvate dehydrogenase complex (PDC) reduces blood glucose levels by directing the carbon of pyruvate into the citric acid cycle. In... -
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- Peutz-Jeghers Syndrome with Adenomatous Change in a Fifteen-month-old Boy
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Lee KS, Lee SH, Myong NH
- KMID: 2373322
- Korean J Gastroenterol.
- 2015 Aug;66(2):106-110.
- doi: 10.4166/kjg.2015.66.2.106
Peutz-Jeghers syndrome (PJS) is a very rare genetic disorder. PJS carries a high risk of developing gastrointestinal (GI) cancer or non-GI cancer with advancing years. However, major symptoms of PJS... -
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- Alkyl Cinnamates Induce Protein Kinase C Translocation and Anticancer Activity against Breast Cancer Cells through Induction of the Mitochondrial Pathway of Apoptosis
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Deka SJ, Mamdi N, Manna D, Trivedi V
- KMID: 2362922
- J Breast Cancer.
- 2016 Dec;19(4):358-371.
- doi: 10.4048/jbc.2016.19.4.358
PURPOSE: The protein kinase C (PKC) family of serine-threonine kinases plays an important role in cancer cell progression. Thus, molecules that target PKC have potential as anticancer agents. The current... -
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- A Case of Myotonic Dystrophy with Electrolyte Imbalance
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Ko WJ, Kim KY, Kim SM, Hong SJ, Lee SH, Song R, Yang HI, Lee YA
- KMID: 1777513
- J Korean Med Sci.
- 2013 Jul;28(7):1111-1113.
- doi: 10.3346/jkms.2013.28.7.1111
Type 1 myotonic dystrophy (DM1) is an autosomal-dominant inherited disorder with a multisystem involvement, caused by an abnormal expansion of the CTG sequence of the dystrophic myotonia protein kinase (DMPK)... -
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- Tumor Suppressor Serine/Threonine Kinase LKB1 Expression, Not Kinase Activity, Increased in the Vascular Smooth Muscle Cells and Neointima in the Rat Carotid Artery Injury Model
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Jeong JO, Kim JH, Ahn KT, Park HS, Jang WI, Park JH, Lee JH, Choi SW, Kim JM, Seong IW
- KMID: 1826173
- Korean Circ J.
- 2010 Nov;40(11):552-557.
- doi: 10.4070/kcj.2010.40.11.552
BACKGROUND AND OBJECTIVES: Vascular smooth muscle cell (VSMC) proliferation is responsible for the restenosis of previously inserted coronary stents. Angiotensin II (Ang II) is known to regulate VSMC proliferation. LKB1,... -
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- Regulation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B activity by casein kinase II- and p56lck-mediated phosphorylation
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Kang KR, Kim CW
- KMID: 927134
- Exp Mol Med.
- 2000 Mar;32(1):47-51.
Protein tyrosine phosphorylation and dephosphorylation are important in the regulation of cell proliferation and signaling cascade. In order to examine whether phosphatase activity of CPTP1 and HPTP1B, typical nontransmembrane protein... -
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- A Case of Near Total Aortic Replacement in an Adolescent With Loeys-Dietz Syndrome
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Suh YJ, Kwon HW, Kim GB, Kwon BS, Bae EJ, Noh CI, Choi JY, Kim KH, Kim YJ, Park SS
- KMID: 2225025
- Korean Circ J.
- 2012 Apr;42(4):288-291.
- doi: 10.4070/kcj.2012.42.4.288
Loeys-Dietz syndrome is a recently described autosomal dominant disorder caused by mutations in the genes for transforming growth factor-beta receptor type 1 or 2 (TGF-ssR 1/2). The syndrome predisposes patients... -
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- Alternative splicing in 5'-untranslational region of STK-15 gene, encoding centrosome associated kinase, in breast cancer cell lines
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Shin SO, Lee KH, Kim JH, Baek SH, Park JW, Gabrielson EW, Kwon TK
- KMID: 755098
- Exp Mol Med.
- 2000 Dec;32(4):193-196.
Centrosomes maintain genomic stability by establishing the bipolar spindles during cell division and, execute accurate segregation of chromosomes during mitosis. In this study, we have demonstrated that there... -
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- Protein kinase CK2 phosphorylates and interacts with deoxyhypusine synthase in HeLa cells
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Kang KR, Chung SI
- KMID: 1119339
- Exp Mol Med.
- 2003 Dec;35(6):556-564.
Deoxyhypusine is a modified lysine and formed posttranslationally to be the eukaryotic initiation factor eIF5A by deoxyhypusine synthase, employing spermidine as butylamine donor. Subsequent hydroxylation of this deoxyhypusine-containing intermediate completes... -
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