Korean Circ J.  2013 Jan;43(1):13-22. 10.4070/kcj.2013.43.1.13.

Association between Serine/Threonine Kinase 39 Gene Polymorphism, Hypertension, and Other Cardiovascular Risk Factors in Koreans

• Shin DJ
• Lee SH
• Park S
• Jang Y

• KMID: 1722996
• DOI: http://doi.org/10.4070/kcj.2013.43.1.13

Abstract

BACKGROUND AND OBJECTIVES
Although the association between single nucleotide polymorphisms (SNPs) of Serine/Threonine Kinase 39 (STK39) and hypertension has been reported, the prior studies have been inconsistent. The aim of this study is to evaluate the association between rs3754777 and rs6749447, the two SNPs of STK39, and hypertension and other cardiovascular risk factors in Koreans, residing in the Republic of Korea.
SUBJECTS AND METHODS
We included 238 hypertensive patients and 260 controls. The associations between genotype and haplotype combination and hypertension were examined. In addition, possible SNP-related differences in the adjusted blood pressure and other cardiovascular risk factors were analyzed.
RESULTS
There was no significant association between the two SNPs and hypertension. However, the carriers of AA genotype of rs3754777 showed lower blood glucose and cholesterol levels, particularly in females. Genotype of rs6749447 was associated with the waist circumference, triglyceride, and high density lipoprotein-cholesterol levels, only in gender-stratified analysis. The effects of haplotype combinations on risk factors were compatible with genotype effects of each SNP.
CONCLUSION
Associations between the two SNPs of STK39, rs3754777 and rs6749447, and hypertension were not significant. However, the two SNPs showed genotype-related differences in blood glucose, lipids, and waist circumference, especially in women. Further studies are needed to clarify the effect of STK39 variants in these cardiovascular risk factors.

Keyword

STK39 protein, human; Hypertension; Cholesterol; Waist circumference; Glucose

MeSH Terms

Blood Glucose
Blood Pressure
Cholesterol
Female
Genotype
Glucose
Haplotypes
Humans
Hypertension
Polymorphism, Single Nucleotide
Protein-Serine-Threonine Kinases
Risk Factors
Waist Circumference
Blood Glucose
Cholesterol
Glucose
Protein-Serine-Threonine Kinases

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