- Influence of the sequence variations of the HLA-DR promoters derived from human melanoma cell lines on nuclear protein binding and promoter activity
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Lee TJ, Kim SJ, Park JH
- KMID: 1062238
- Yonsei Med J.
- 2000 Oct;41(5):593-599.
- doi: 10.3349/ymj.2000.41.5.593
In previous studies we reported that the expression of HLA-DR on melanoma cell lines was differentially modulated by IFN- gamma and that the transcription rate was responsible for this differential... -
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- In vivo determination of the gap2 gene promoter activity in Giardia lamblia
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Yang HW, Kim J, Yong TS, Park SJ
- KMID: 1091832
- Korean J Parasitol.
- 2006 Mar;44(1):21-26.
- doi: 10.3347/kjp.2006.44.1.21
A shuttle vector for Escherichia coli and Giardia lamblia was modified to produce a reporter plasmid, which monitors the expression of prescribed gene in G. lamblia by measuring its luciferase... -
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- A Study of Polymorphism in UDP-glucuronosyltransferase 1 (UGT-1A1) Promoter Gene in Korean Patients with Gilbert's Syndrome
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Kim YH, Yeon JE, Jung GM, Kim HJ, Kim JS, Byun KS, Bak YT, Lee CH
- KMID: 1123162
- Korean J Hepatol.
- 2002 Jun;8(2):132-138.
BACKGROUNDS/AIMS: Hepatic glucuronidating activity, essential for efficient biliary excretion of bilirubin, is reduced to about 30 percent of normal in patients with Gilbert's syndrome. Patients with Gilbert's syndrome have an... -
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- C/EBP binding activity to site F of the rat GLUT2 glucose transporter gene promoter is attenuated by c-Jun in vitro
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Kim JW, Ahn YH
- KMID: 755211
- Exp Mol Med.
- 2002 Nov;34(5):379-384.
The expression of the GLUT2 glucose transporter gene in liver is suppressed in cultured hepatoma cell lines and primary cultured hepatocytes. Earlier report showed that CCAAT/enhancer binding protein (C/EBP) regulates... -
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- The DPE, a core promoter element for transcription by RNA polymerase II
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Kadonaga J
- KMID: 931875
- Exp Mol Med.
- 2002 Sep;34(4):259-264.
The core promoter is an important yet often overlooked component in the regulation of transcription by RNA polymerase II. In fact, the core promoter is the ultimate target of... -
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- Characterization of cis-acting elements in the rat ATP citrate-lyase gene promoter
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Moon YA, Park SW, Kim KS
- KMID: 1093599
- Exp Mol Med.
- 2002 Mar;34(1):60-68.
The cis-acting element in the promoter of the rat ATP-citrate lyase (ACL) and transcription factors which interact with these elements were determined. Six Sp1 binding sites and CAAT box exist... -
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- Cloning and characterization of 5'-upstream region of human phospholipase C-beta2 gene
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Yun ES, Lee SJ, Kim MJ, Ryu SH, Suh PG
- KMID: 1085743
- Exp Mol Med.
- 2001 Jun;33(2):76-82.
5'-upstream region of the phospholipase C-beta2 gene, 810 bp, was cloned and characterized. S1 nuclease mapping and primer extension analyses revealed that a single transcriptional start site locates at 284... -
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- Analysis of the precore and core promoter DNA sequence in liver tissues from tients with hepatocellular carcinoma
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Cho SW, Shin YJ, Hahm KB, Jin JH, Kim YS, Kim JH, Kim HJ
- KMID: 1731317
- J Korean Med Sci.
- 1999 Aug;14(4):424-430.
- doi: 10.3346/jkms.1999.14.4.424
To investigate the role of mutant hepatitis B virus (HBV) in the development of hepatocellular carcinoma (HCC), 20 patients with HCC were studied for precore and core promoter mutations in... -
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- Association between interleukin 6 promoter variants and chronic hepatitis B progression
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Park BL, Lee HS, Kim YJ, Kim JY, Jung JH, Kim LH, Shin HD
- KMID: 1097254
- Exp Mol Med.
- 2003 Apr;35(2):76-82.
Interleukin 6 (IL6) plays an essential role in the regulation of immune response to chronic disease. In this study, the three known single nucleotide polymorphisms (SNPs) in the IL6 promoter... -
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- Different protein-binding patterns in the P3 promoter region of the human insulin-like growth factor II gene in the human liver cirrhosis and hepatocellular carcinoma tissues
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Seo JH, Kim KW, Park BC
- KMID: 1064965
- J Korean Med Sci.
- 1998 Apr;13(2):171-178.
- doi: 10.3346/jkms.1998.13.2.171
The P3 promoter of the human insulin-like growth factor II (IGF-II) is the major IGF-II promoter in fetal liver (FL) and hepatocellular carcinoma (HCC). However, little information is available... -
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- Inactivation patterns of p16/INK4A in oral squamous cell carcinomas
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Lee JK, Kim MJ, Hong SP, Hong SD
- KMID: 1380211
- Exp Mol Med.
- 2004 Apr;36(2):165-171.
The p16/INK4A is one of the major target genes in carcinogenesis and its inactivation has frequently been reported in other types of tumors. The purpose of this study is to... -
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- Regulation of fibronectin gene expression by cyclic AMP and phorbol myristate acetate in HT-1080 human fibrosarcoma cells
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Lee BH, Park RW, Kim IS
- KMID: 755015
- Exp Mol Med.
- 1998 Dec;30(4):240-245.
We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells. Dibutyryl cAMP increased FN synthesis and mRNA levels, while PMA inhibited... -
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- Cancer Epigenetics
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Chang DK
- KMID: 1113291
- Korean J Gastroenterol.
- 2004 Jul;44(1):1-12.
Knowledge regarding molecular events of cancer development has been rapidly accumulated during the last decade. The discovery of tumor suppressor gene-silencing by aberrant promoter CpG island hypermethylation and histone-directed chromatin... -
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- Transcriptional repression of type I procollagen genes during adipocyte differentiation
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Yi TG, Choi HM, Park RW, Sohn KY, Kim IS
- KMID: 1457541
- Exp Mol Med.
- 2001 Dec;33(4):269-275.
Adipocyte differentiation is a very complex process in which whole-cell changes are accompanied. Among them, type I procollagen gene has been shown to specifically decrease during adipocyte differentiation; however, little... -
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- Development of an efficient endothelial cell specific vector using promoter and 5' untranslated sequences from the human preproendothelin-1 gene
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Cho JY, Lim WC, Jang S, Lee YJ
- KMID: 1109315
- Exp Mol Med.
- 2003 Aug;35(4):269-274.
We report here, that a vector constructed based on ppET-1 gene promoter and 5' untranslated region induced a high level of gene expression in endothelial cells and the specificity is... -
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- Genetic factors associated with development of cerebral malaria and fibrotic schistosomiasis
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Hirayama K
- KMID: 1384728
- Korean J Parasitol.
- 2002 Dec;40(4):165-172.
- doi: 10.3347/kjp.2002.40.4.165
Collaborative studies have identified some genetic factors contributing to the development of severe forms of malaria and schistosomiasis. In Thailand, the TNF-alpha 5'-flanking region shows biallelic polymorphic sites at nucleotides... -
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- Low-dose radiation response of the p21(WAF1/CIP1) gene promoter transduced by adeno-associated virus vector
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Nenoi M, Daino K, Ichimura S, Takahash S, Akuta T
- KMID: 1098090
- Exp Mol Med.
- 2006 Oct;38(5):553-564.
In cancer gene therapy, restriction of antitumor transgene expression in a radiation field by use of ionizing radiation-inducible promoters is one of the promising approaches for tumor-specific gene delivery. Although... -
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- Association of TNFA Promoter Region Haplotype in Behcet's Disease
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Park KS, Kim NY, Nam JH, Bang D, Lee ES
- KMID: 2157807
- J Korean Med Sci.
- 2006 Aug;21(4):596-601.
- doi: 10.3346/jkms.2006.21.4.596
Although the etiology of Behcet's Disease (BD; MIM 109650) remains to be clearly elucidated, levels of tumor necrosis factor alpha (TNF-alpha) have been reported to be significantly elevated in BD... -
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- Interleukin-10 Promoter Polymorphism is Associated with the Predisposition to the Development of IgA Nephropathy and Focal Segmental Glomerulosclerosis in Korea
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Chin HJ, Na KY, Kim SJ, Oh KH, Kim YS, Lim CS, Kim S, Chae DW
- KMID: 2157750
- J Korean Med Sci.
- 2005 Dec;20(6):989-993.
- doi: 10.3346/jkms.2005.20.6.989
The roles of interleukin-10 (IL-10) have been emphasized in several models of glomerulonephritis (GN). Three biallelic polymorphisms within the IL-10 promoter region, at positions -1,082, -819, and -592 from the... -
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- The Prevalence and Clinical Significance of Precore and Core Promoter Mutations in Korean Patients with hronic Hepatitis B Virus Infection
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Kim HJ, Yoo BC
- KMID: 1123164
- Korean J Hepatol.
- 2002 Jun;8(2):149-156.
BACKGROUND/AIMS: Precore and core promoter mutations of hepatitis B virus (HBV) have been reported in Korea but their prevalence and clinical significance have not been determined. The aims of this... -
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