- D60-sensitive tyrosine phosphorylation is involved in Fas-mediated phospholipase D activation
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Kim JG, Shin IC, Lee KS, Han JS
- KMID: 1457546
- Exp Mol Med.
- 2001 Dec;33(4):303-309.
Both Fas and PMA can activate phospholipase D via activation of protein kinase Cbeta in A20 cells. Phospholipase D activity was increased 4 fold in the presence of Fas and... -
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- Activation of Neutrophil Menbrane Phospholipase D by Soluble Proteins: Comparison of Cytosolic Neutrophil 50 kDa Factor , ADP-ribosylation Factor and a Novel Brain Factor
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Kim Y, Kwak JY, Lee TH, Lopez I, Lameth JD, Shu PG, Ryu SH
- KMID: 1550768
- Korean J Immunol.
- 1999 Sep;21(3):183-191.
GTPrS-dependent phospholipase D activity in human neutrophils was investigated using exogenous phospholipid as a substrate. Both cytosolic and membrane- associated phospholipase D activities were identified. The previously described 50 kDa... -
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- Phospholipase Activities in Clinical and Environmental Isolates of Acanthamoeba
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Matin A, Jung SY
- KMID: 1715626
- Korean J Parasitol.
- 2011 Mar;49(1):1-8.
- doi: 10.3347/kjp.2011.49.1.1
The pathogenesis and pathophysiology of Acanthamoeba infections remain incompletely understood. Phos-pholipases are known to cleave phospholipids, suggesting their possible involvement in the host cell plasma membrane disruption leading to host... -
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- Effect of Extremely Low Frequency Electromagnetic Fields (EMF) on Phospholipase Activity in the Cultured Cells
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Song HS, Kim HR, Ko MS, Jeong JM, Kim YH, Kim MC, Hwang YH, Sohn UD, Gimm YM, Myung SH, Sim SS
- KMID: 2071716
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):427-433.
- doi: 10.4196/kjpp.2010.14.6.427
This study was conducted to investigate the effects of extremely low frequency electromagnetic fields (EMF) on signal pathway in plasma membrane of cultured cells (RAW 264.7 cells and RBL 2H3... -
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- Major house dust mite allergen, Der p I, activates phospholipase D in human peripheral blood mononuclear cells from allergic patients: involvement of protein kinase C
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Oh JW, Kim JH, Lee KS, Han JS
- KMID: 1109304
- Exp Mol Med.
- 2000 Jun;32(2):67-71.
The major house-dust-mite allergen, Der p I, stimulates the phospholipase D (PLD) in peripheral blood mononuclear cells (PBMC) from allergic patients with maximal responses after 30 min exposure. At 30... -
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- The Expression of Phospholipase D in Gastric Carcinoma
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Park TH, Choi SR, Jung JS, Yoon S, Park JI, Kwak JY, Roh MH, Han SY, Shin WW
- KMID: 2084952
- Korean J Gastroenterol.
- 1999 Sep;34(3):308-316.
BACKGROUND/AIMS: Phospholipase D (PLD) is known to play an important role in cell proliferation and tumorigenesis. The aim of the present study was to examine the relation between PLD expression... -
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- The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus
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Jang YH, Min DS
- KMID: 1506220
- Exp Mol Med.
- 2012 Oct;44(10):571-577.
Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. PLD is localized in most cellular organelles, where it is likely to play different... -
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- Lysophosphatidylcholine suppresses apoptosis and induces neurite outgrowth in PC12 cells through activation of phospholipase D2
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Yun DH, Jeon ES, Sung SM, Ryu SH, Kim JH
- KMID: 1110121
- Exp Mol Med.
- 2006 Aug;38(4):375-384.
Lysophosphatidylcholine (LPC) is a bioactive lipid generated by phospholipase A2-mediated hydrolysis of phosphatidylcholine. In the present study, we demonstrate that LPC stimulates phospholipase D2 (PLD2) activity in rat pheochromocytoma PC12... -
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- Effect of Ethanol on the Regulation of Smooth Muscle Tone in Rat Aorta
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Suh DJ, Bae HR, Jung DK, Lee JH
- KMID: 1858589
- Korean Circ J.
- 2001 Feb;31(2):230-237.
- doi: 10.4070/kcj.2001.31.2.230
BACKGROUND AND OBJECTIVES: The aim of this study was to determine the effect of ethanol on the regulation of vascular tone. MATERIAL AND METHODS: Using rat aorta ring, isometric contraction... -
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- Effect of ceramide on apoptosis and phospholipase D activity in FRTL-5 thyroid cells
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Park BJ, Kim JH, Han JS, Jung PM
- KMID: 755043
- Exp Mol Med.
- 1999 Sep;31(3):142-150.
Ceramide, a product of sphingomyelin hydrolysis, is now recognized as an intracellular lipid messenger, which mediates the effects of extracellular agents on cellular growth, differentiation and apoptosis. Recently, ceramide has been implicated in... -
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- Dexamethasone enhances phospholipase D activity in M-1 cells
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Kim WJ, Lee MJ, Park MA, Jung JS, Uhlinger D, Kwak JY
- KMID: 755082
- Exp Mol Med.
- 2000 Sep;32(3):170-177.
Phospholipase D (PLD) is an enzyme involved in signal transduction and widely distributed in mammalian cells. The signal transduction pathways and role for phospholipid metabolism during hormonal response in... -
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- Immunohistochemical Localization of Phospholipase D1 in Developing Rat Forebrain
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Choi JS, Min DS, Chung JW, Chun MH, Lee MY
- KMID: 1559034
- Korean J Anat.
- 2001 Aug;34(4):427-434.
Phospholipase D (PLD), one of the intracellular signal transduction enzymes, may play an important role in developing brain. However, the developmental regulation of PLD protein has not been determined. In... -
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- Alteration of Oleate-Phospholipase D Activities in Some Cell Lines after Irradiation
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Kim CY, Choi MU, Choi MS
- KMID: 2006786
- J Korean Cancer Assoc.
- 1997 Dec;29(6):944-953.
PURPOSE: Phospholipase D (PLD) catalyzes the hydrolytic cleavage of terminal phosphate diester bond of glycerophopholipids to produce phosphatidic acid (PA). PLD plays an important role in signal transduction and is... -
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- The expression and cellular localization of phospholipase D isozymes in the developing mouse testis
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Kim S, Kim H, Lee Y, Hyun JW, Lee YH, Shin MK, Min DS, Shin T
- KMID: 1090792
- J Vet Sci.
- 2007 Sep;8(3):209-212.
- doi: 10.4142/jvs.2007.8.3.209
To examine the involvement of phospholipase D (PLD)isozymes in postnatal testis development, the expression ofPLD1 and PLD2 was examined in the mouse testis atpostnatal weeks 1, 2, 4, and 8... -
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- Effects of ginsenosides on the mechanism of histamine release in the guinea pig lung mast cells activated by specific antigen-antibody reactions
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Ro JY, Ahn YS, Kim KH
- KMID: 2071516
- Korean J Physiol Pharmacol.
- 1997 Aug;1(4):445-456.
We previously reported that some components of ginsenosides decreased mediator releases evoked by the activation of mast cells with specific antigen-antibody reactions. This study aimed to assess the effects of ginsenosides (Rb2, Re)... -
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- Effect of TRH on Phospholipase D Activity in GH3 Cell
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Kim DS, Lee CB, Ahn YH, Kim TW, Yoon MS, Han JS
- KMID: 2199978
- J Korean Soc Endocrinol.
- 2002 Aug;17(4):465-472.
BACKGROUND: GH3 cells are a well characterized and widely used model used for the in vitro study of growth hormone (GH) secretion. Thyrotropin releasing hormone (TRH) binds to receptors ... -
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- Differential effects of Fas cross-linking on phospholipase D activation and related lipid metabolism in Fas-resistant A20 cells.
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Lim SY, Lee SC, Shin IC, Han JS
- KMID: 1380228
- Exp Mol Med.
- 2002 Jul;34(3):201-210.
A20 murine lymphoma cells undergoing Fas-mediated apoptosis showed increase in the activity of phospholipase D (PLD), which is involved in proliferative or mitogenic cellular responses. Using A20 cell lines that... -
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- Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells
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Son JC, Kang DW, Yang KM, Choi KY, Son TG, Min DS
- KMID: 2154257
- Exp Mol Med.
- 2013 Aug;45(8):e38.
Radiation and drug resistance remain the major challenges and causes of mortality in the treatment of locally advanced, recurrent and metastatic breast cancer. Dysregulation of phospholipase D (PLD) has been... -
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- Changes of phospholipase D activity in TNF-alpha and anti-Fas/Apo1 monoclonal antibody induced apoptosis in HL-60 and A20 cells
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Kang JH, Shin IC, Han JS
- KMID: 754983
- Exp Mol Med.
- 1998 Mar;30(1):21-27.
The changes of phospholipase D (PLD) activity were investigated during the courses of apoptotic process induced by tumor necrosis factor (TNF)-alpha or anti-Fas/Apo1 antibody in human premyelocyte HL-60 and murine B cell... -
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- Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase
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Jang MJ, Lee MJ, Park HY, Bae YS, Min DS, Ryu SH, Kwak JY
- KMID: 1380212
- Exp Mol Med.
- 2004 Apr;36(2):172-178.
Agents that elevate cellular cAMP are known to inhibit the activation of phospholipase D (PLD). We investigated whether PLD can be phosphorylated by cAMP-dependent protein kinase (PKA) and PKA-mediated phosphorylation... -
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