- Physiological spaces and multicompartmental pharmacokinetic models
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Atkinson A
- KMID: 2351805
- Transl Clin Pharmacol.
- 2015 Dec;23(2):38-41.
- doi: 10.12793/tcp.2015.23.2.38
The idea of body compartments has its origins in physiology and antedates their use in both physiologically-based predictive pharmacokinetic models and in the simpler compartmental models used to analyze pharmacokinetic... -
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- Derivation of pharmacokinetic equations
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Noh GJ
- KMID: 2435992
- Anesth Pain Med.
- 2018 Oct;13(4):349-362.
- doi: 10.17085/apm.2018.13.4.349
A variety of drugs are continuously or intermittently administered to patients during general or regional anesthesia. Pharmacotherapy should also receive priority compared with several treatment modalities including nerve blocks for... -
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- Contributing Factors on Pharmacokinetic Variability in Critically Ill Neonates
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An SH
- KMID: 2387585
- Korean J Clin Pharm.
- 2017 Jun;27(2):63-68.
- doi: 10.24304/kjcp.2017.27.2.63
Neonates have large inter-individual variability in pharmacokinetic parameters of many drugs due to developmental differences. The aim of this study was to investigate the factors affecting the pharmacokinetic parameters of... -
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- How to design intravenous anesthetic dose regimens based on pharmacokinetics and pharmacodynamics principles
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Park JC
- KMID: 2148006
- Anesth Pain Med.
- 2015 Oct;10(4):235-244.
- doi: 10.17085/apm.2015.10.4.235
Pharmacokinetics is the study of the rate and degree of drug transport to various tissues in the human body. Pharmacokinetic parameters summarize drug kinetics and ideally predict a clinical situation.... -
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- Comparative Study of First-in-Human Dose Estimation Approaches using Pharmacometrics
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Baek IH
- KMID: 2358067
- Korean J Clin Pharm.
- 2016 Jun;26(2):150-162.
- doi: 10.0000/kjcp.2016.26.2.150
OBJECTIVE: First-in-human dose estimation is an essential approach for successful clinical trials for drug development. In this study, we systematically compared first-in-human dose and human pharmacokinetic parameter estimation approaches. METHODS: First-in-human... -
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- Pharmacokinetic variability due to environmental differences
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Holford N
- KMID: 2386761
- Transl Clin Pharmacol.
- 2017 Jun;25(2):59-62.
- doi: 10.12793/tcp.2017.25.2.59
This tutorial describes sources of pharmacokinetic variability that are not obviously linked to genetic differences. The sources of variability are therefore described as environmental. The major quantitative sources of environmental... -
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- Comparison of Piroxicam Pharmacokinetics and Anti-Inflammatory Effect in Rats after Intra-Articular and Intramuscular Administration
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Park CW, Ma KW, Jang SW, Son M, Kang MJ
- KMID: 2170645
- Biomol Ther.
- 2014 May;22(3):260-266.
This study evaluated the pharmacokinetic profile and therapeutic efficacy of piroxicam (PX), a long acting non-steroidal anti-inflammatory drug for the treatment of arthritis, following intra-articular (IA) injection in comparison to... -
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- Tacrolimus versus Cyclosporine Immunosuppression in Pediatric Renal Transplantation: Pharmacokinetic Consideration
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Kim JS
- KMID: 2278619
- Korean J Pediatr.
- 2005 May;48(5):476-480.
Immunosuppressive therapy in pediatric renal transplant recipients is changing consequence of the increasing number of available immunosuppressive agents. The optimal use of immunosuppressive agents requires a thorough understanding of the... -
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- Pharmacokinetic and pharmacodynamic modeling in anesthetic field
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Han DW
- KMID: 1797465
- Anesth Pain Med.
- 2014 Apr;9(2):77-86.
Models are simplified descriptions of true biological processes. Pharmacokinetic/pharmacodynamic (PK/PD) modeling is a mathematical description on the relationship between pharmacokinetics and pharmacodynamics. The PK/PD modeling allows estimation of PK/PD parameters... -
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- Population Pharmacokinetic and Pharmacodynamic Modeling in Beagle Dogs Sedated by Propofol Microemulsion
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Choi BM, Jung SM, Bae KS, Noh GJ
- KMID: 1862247
- Korean J Anesthesiol.
- 2006 Jun;50(6):689-697.
- doi: 10.4097/kjae.2006.50.6.689
BACKGROUND: Aquafol(R) is a microemulsion formulation of propofol. This study was designed to investigate the population pharmacokinetic and pharmacodynamic modeling in beagle dogs sedated by Aquafol(R). METHODS: Electroencephalogram was recorded... -
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- Changes of Propranolol Pharmacokinetic Parameters According to Hepatic Fibrotic Severity in CCl4-Treated Rats
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Kang MS, Yoon CO, Byun JW, Lee OY, Yoon BC, Hahm JS, Kang JS, Lee MH
- KMID: 2241247
- Korean J Hepatol.
- 2001 Jun;7(2):181-188.
BACKGROUND/AIMS: This study was designed to determine the effect of hepatic fibrotic severity on pharmacokinetics of propranolol in CCl4-treated rats. METHODS: 1 mL/kg of 10% CCl4 in olive oil... -
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- Understanding the pharmacokinetics of prodrug and metabolite
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Cho S, Yoon YR
- KMID: 2420300
- Transl Clin Pharmacol.
- 2018 Mar;26(1):1-5.
- doi: 0.12793/tcp.2018.26.1.1
This tutorial explains the pharmacokinetics of a prodrug and its active metabolite (or parent drug) using a two-step, consecutive, first-order irreversible reaction as a basic model for prodrug metabolism. In... -
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- Interspecies pharmacokinetic scaling of 11-hydroxyaclanomycin X based on animal data
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Shin DH, Lee SY, Jeong SW, Park CW, Chung YB
- KMID: 2377352
- J Biomed Transl Res.
- 2017 Mar;18(1):24-29.
- doi: 10.12729/jbtr.2017.18.1.024
The pharmacokinetics of 11-Hydroxyaclacinomycin X (HAMX), a novel anthracycline, were investigated after intravenous bolus administration in mice, rats, rabbits and dogs. Based on animal data, we predicted the following human... -
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- Pharmacokinetic Equivalence of the High Dose Strength Fixed-Dose Combination Tablet of Gemigliptin/Metformin Sustained Release (SR) and Individual Component Gemigliptin and Metformin XR Tablets in Healthy Subjects
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Cho YS, Lee SH, Lim HS, Bae KS
- KMID: 2421399
- J Korean Med Sci.
- 2018 Oct;33(41):e258.
- doi: 10.3346/jkms.2018.33.e258
BACKGROUND: In type 2 diabetes mellitus therapy, fixed-dose combination (FDC) can offer not only benefits in glucose control via the combined use of agents, but also increase patient compliance. The... -
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- Comparative pharmacokinetic and tolerability evaluation of two simvastatin 20 mg formulations in healthy Korean male volunteers
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Moon SJ, Lee S, Jang K, Yu KS, Yim SV, Kim BH
- KMID: 2411413
- Transl Clin Pharmacol.
- 2017 Mar;25(1):10-14.
- doi: 10.12793/tcp.2017.25.1.10
Simvastatin is used to reduce plasma cholesterol by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and is primarily used to treat hypercholesterolemia. This study was conducted to assess the bioequivalence between... -
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- Serum Cystatin C Is a Major Predictor of Vancomycin Clearance in a Population Pharmacokinetic Analysis of Patients with Normal Serum Creatinine Concentrations
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Chung JY, Jin SJ, Yoon JH, Song YG
- KMID: 2158000
- J Korean Med Sci.
- 2013 Jan;28(1):48-54.
- doi: 10.3346/jkms.2013.28.1.48
We developed a population pharmacokinetic model of vancomycin by integrating the effects of cystatin C and other demographic factors in a large population of Korean patients with normal serum creatinine... -
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- Pharmacokinetic Interaction of Chrysin with Caffeine in Rats
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Noh K, Oh DG, Nepal MR, Jeong KS, Choi Y, Kang MJ, Kang W, Jeong HG, Jeong TC
- KMID: 2351695
- Biomol Ther.
- 2016 Jul;24(4):446-452.
- doi: 10.4062/biomolther.2015.197
Pharmacokinetic interaction of chrysin, a flavone present in honey, propolis and herbs, with caffeine was investigated in male Sprague-Dawley rats. Because chrysin inhibited CYP1A-selective ethoxyresorufin O-deethylase and methoxyresorufin O-demethylase activities... -
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- Preclinical Pharmacokinetic Evaluation of beta-Lapachone: Characteristics of Oral Bioavailability and First-Pass Metabolism in Rats
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Kim I, Kim H, Ro J, Jo K, Karki S, Khadka P, Yun G, Lee J
- KMID: 2380341
- Biomol Ther.
- 2015 May;23(3):296-300.
- doi: 10.4062/biomolther.2015.029
beta-Lapachone has drawn increasing attention as an anti-inflammatory and anti-cancer drug. However, its oral bioavailability has not been yet assessed, which might be useful to develop efficient dosage forms possibly... -
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- The comparison of predictive performance in bispectral index prediction during target effect-site controlled infusion of propofol using different blood effect-site equilibration rate constants in the same pharmacokinetic model
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Choi BM, Bang JY, Jung KW, Lee JH, Bae HY, Noh GJ
- KMID: 2164864
- Korean J Anesthesiol.
- 2013 Oct;65(4):299-305.
- doi: 10.4097/kjae.2013.65.4.299
BACKGROUND: Blood-brain equilibration rate constant (k(e0)) is derived from either pharmacokinetic and pharmacodynamic modeling (k(e0_model)) or a model-independent observed time to peak effect (k(e0_tpeak)). Performance in bispectral index (BIS) prediction... -
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- The Pharmacokinetic Characteristics of Methylprednisolone in Korean Renal Transplant Recipients
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Ahn JH, Kahng KW, Kang JS, Shin IC, Kang CM, Kwak JY
- KMID: 2079036
- Korean J Nephrol.
- 1998 Sep;17(5):798-806.
Glucocorticoids are usually given according to a standard dosing protocol regardless of individual difference. We evaluated the pharmacokinetic characteristics of methylprednisolone and the degree of interpatient variation in stable Korean... -
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