- Epilepsy and Oxidative Stress
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Kim WS
- KMID: 1640564
- J Korean Epilepsy Soc.
- 2004 Dec;8(2):103-107.
Epilepsy is arising from many molecular and biochemical events. In the underlying mechanisms of epilepsy, oxidative stress plays an important role in seizure-induced brain damage and neuronal death. Also epileptic... -
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- Epilepsy, Reactive Oxygen Species and Mitochondria
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Kim WS
- KMID: 2177006
- J Korean Child Neurol Soc.
- 2005 May;13(1):1-7.
Epilepsy is a neurological disorder from many molecular and biochemical responses. In the underlying mechanism, reactive oxygen species play an important role in seizure initiation and seizure-induced brain damage. In... -
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- Role of Mitochondrial Oxidative Stress in Sepsis
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Nagar H, Piao S, Kim CS
- KMID: 2436313
- Acute Crit Care.
- 2018 May;33(2):65-72.
- doi: 10.4266/acc.2018.00157
Mitochondria are considered the power house of the cell and are an essential part of the cellular infrastructure, serving as the primary site for adenosine triphosphate production via oxidative phosphorylation.... -
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- The First Korean case of combined oxidative phosphorylation deficiency-17 diagnosed by clinical and molecular investigation
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Kim YA, Kim YM, Lee YJ, Cheon CK
- KMID: 2398890
- Korean J Pediatr.
- 2017 Dec;60(12):408-412.
- doi: 10.3345/kjp.2017.60.12.408
Combined oxidative phosphorylation deficiency-17 (COXPD-17) is very rare and is caused by homozygous or compound heterozygous mutations in the ELAC2 gene on chromosome 17p12. The ELAC2 gene functions as a... -
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- NecroX-5 protects mitochondrial oxidative phosphorylation capacity and preserves PGC1alpha expression levels during hypoxia/reoxygenation injury
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Thu VT, Kim HK, Long LT, Nyamaa B, Song IS, Thuy TT, Huy NQ, Marquez J, Kim SH, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2388677
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):201-211.
- doi: 10.4196/kjpp.2016.20.2.201
Although the antioxidant and cardioprotective effects of NecroX-5 on various in vitro and in vivo models have been demonstrated, the action of this compound on the mitochondrial oxidative phosphorylation system... -
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- Cancer Energy Metabolism: Shutting Power off Cancer Factory
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Kim SY
- KMID: 2400813
- Biomol Ther.
- 2018 Jan;26(1):39-44.
- doi: 10.4062/biomolther.2017.184
In 1923, Dr. Warburg had observed that tumors acidified the Ringer solution when 13 mM glucose was added, which was identified as being due to lactate. When glucose is the... -
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- Evolution of Energy Metabolism, Stem Cells and Cancer Stem Cells: How the Warburg and Barker Hypotheses Might Be Linked
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Trosko JE, Kang KS
- KMID: 1426156
- Int J Stem Cells.
- 2012 May;5(1):39-56.
The evolutionary transition from single cells to the metazoan forced the appearance of adult stem cells and a hypoxic niche, when oxygenation of the environment forced the appearance of oxidative... -
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- Mechanism of Developing Diabetic Vascular Complication by Oxidative Stress
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Kim BH, Son SM
- KMID: 2391899
- J Korean Endocr Soc.
- 2006 Dec;21(6):448-459.
Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in the patients with diabetes mellitus. Oxidative stress has been postulated to be a major contributor to... -
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- Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
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Park S, Jeon JH, Min BK, Ha CM, Thoudam T, Park BY, Lee IK
- KMID: 2418715
- Diabetes Metab J.
- 2018 Aug;42(4):270-281.
- doi: 10.4093/dmj.2018.0101
Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial... -
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- Mitochondrial dysfunction reduces the activity of KIR2.1 K⺠channel in myoblasts via impaired oxidative phosphorylation
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Woo J, Kim HJ, Nam YR, Kim YK, Lee EJ, Choi I, Kim SJ, Lee W, Nam JH
- KMID: 2430092
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):697-703.
- doi: 10.4196/kjpp.2018.22.6.697
Myoblast fusion depends on mitochondrial integrity and intracellular Ca²⺠signaling regulated by various ion channels. In this study, we investigated the ionic currents associated with [Ca²âº]i regulation in normal and... -
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- Glucose Toxicity and Pancreatic Beta Cell Dysfunction in Type 2 Diabetes
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Won KC, Yoon JS
- KMID: 2298087
- Korean Diabetes J.
- 2008 Jun;32(3):175-181.
- doi: 10.4093/kdj.2008.32.3.175
The adverse effects of prolonged exposure of pancreatic islets to supraphysiologic glucose concentrations (i.e. glucose toxicity) is mediated at least in part by glucose oxidation and the subsequent generation of... -
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- Effects of Hypothermia on Astrocytes Death Due to Depolarization or Inhibitors of Glycolysis and Oxidative Phosphorylation
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Kim MH, Shin B
- KMID: 2237750
- Korean J Anesthesiol.
- 1997 Jun;32(6):895-901.
- doi: 10.4097/kjae.1997.32.6.895
BACKGROUND: There are evidences that cytotoxic cell death occurs first by intracellular sodium entry and then followed by calcium accumulation during ischemic damage. To investigate the protective effect of hypothermia... -
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- The Changes of Arterial Ketone Body Ratio and Osmolal Gap during Hemorrhagic Shock in Rabbit
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Kim IH, Lee KW, Choi YK, Kim YJ, Park JY, Shin CM, Park JY
- KMID: 1752551
- Korean J Anesthesiol.
- 1994 May;27(5):421-427.
- doi: 10.4097/kjae.1994.27.5.421
The ratio of acetoacetate to 8-hydroxybutyrate (ketone body ratio) in the blood may reflects the mitochondrial free NAD+/NADH ratio in the liver. Also arterial ketone body ratio will reflects the... -
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- Changes in Gene Expression in the Rat Hippocampus after Focal Cerebral Ischemia
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Chung JY, Yi JW, Kim SM, Lim YJ, Chung JH, Jo DJ
- KMID: 1963604
- J Korean Neurosurg Soc.
- 2011 Sep;50(3):173-178.
- doi: 10.3340/jkns.2011.50.3.173
OBJECTIVE: The rat middle cerebral artery thread-occlusion model has been widely used to investigate the pathophysiological mechanisms of stroke and to develop therapeutic treatment. This study was conducted to analyze... -
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- Pro-apoptotic Cytochrome c Gene Mutation is Rare in Non-small Cell Lung Cancers
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Soung YH, Lee SH
- KMID: 2200171
- J Lung Cancer.
- 2006 Dec;5(2):111-113.
- doi: 10.6058/jlc.2006.5.2.111
PURPOSE: Several lines of evidence have indicated that the deregulation of apoptosis is involved in the mechanisms of cancer development, and somatic mutations of the apoptosis-related genes have been reported... -
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- Mitochondrial disorders
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Lee YM, Kim HD
- KMID: 2168068
- Hanyang Med Rev.
- 2005 Aug;25(3):12-18.
Mitochondria contain the respiratory chain enzyme complexes that carry out oxidative phosphorylation and produce the majority of cellular energy in the form of ATP. Mitochondrial disorders are either due to... -
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- The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy
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Cho ES, Cha YH, Kim HS, Kim NH, Yook JI
- KMID: 2400812
- Biomol Ther.
- 2018 Jan;26(1):29-38.
- doi: 10.4062/biomolther.2017.179
During cancer progression, cancer cells are repeatedly exposed to metabolic stress conditions in a resource-limited environment which they must escape. Increasing evidence indicates the importance of nicotinamide adenine dinucleotide phosphate... -
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- Mitochondrial Disorders
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Lee YM
- KMID: 1528177
- J Korean Child Neurol Soc.
- 2007 May;15(1):11-19.
Mitochondria contain respiratory chain enzyme complexes that carry out oxidative phosphorylation and produce a main part of cellular energy in the form of ATP. Mitochondrial disorders occur either due to... -
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- Roles of Reactive Oxygen Species on Insulin Resistance in Adipose Tissue
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Han CY
- KMID: 2368513
- Diabetes Metab J.
- 2016 Aug;40(4):272-279.
- doi: 10.4093/dmj.2016.40.4.272
Obesity resulting from the delivery of an excess amount of energy to adipose tissue from glucose or free fatty acids is associated with insulin resistance and adipose tissue inflammation. Reactive... -
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- Effects of exercise on obesity-induced mitochondrial dysfunction in skeletal muscle
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Heo JW, No MH, Park DH, Kang JH, Seo DY, Han J, Neufer PD, Kwak HB
- KMID: 2395251
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):567-577.
- doi: 10.4196/kjpp.2017.21.6.567
Obesity is known to induce inhibition of glucose uptake, reduction of lipid metabolism, and progressive loss of skeletal muscle function, which are all associated with mitochondrial dysfunction in skeletal muscle.... -
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