- Deoxycholic Acid-Induced Signal Transduction in HT-29 Cells: Role of NF-kappa B and Interleukin-8
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Lee DK, Park SY, Baik SK, Kwon SO, Chung JM, Oh ES, Kim HS
- KMID: 772624
- Korean J Gastroenterol.
- 2004 Mar;43(3):176-185.
BACKGROUND/AIMS: Deoxycholic acid (DCA) has been appeared to be an endogenous colon tumor promoter. In this study, we investigated whether DCA induces nuclear factor-kappa B (NF-kappa B) activation and... -
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- Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN-induced matrix metalloproteinase-9 expression
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Lim EJ, Lee SH, Lee JG, Kim JR, Yun SS, Baek SH, Lee C
- KMID: 1094665
- Exp Mol Med.
- 2007 Apr;39(2):239-245.
Unmethylated CpG oligodeoxynucleotides (CpG ODNs) activate immune cells to produce immune mediators. This study demonstrates that in murine macrophage RAW 264.7 cells, CpG ODN-mediated matrix metalloproteinase-9 (MMP-9) expression is regulated... -
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- Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB
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Kyung TW, Lee JE, Shin HH, Choi HS
- KMID: 1103588
- Exp Mol Med.
- 2008 Feb;40(1):52-58.
- doi: 10.3858/emm.2008.40.1.52
Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its... -
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- Clinical Usefulness of Glucocorticoid Receptor beta Expression and NF-kappa B Activity in Patients with Ulcerative Colitis
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Kim KJ, Myung SJ, Hong SS, Lee YJ, Lee SM, Byeon JS, Yang SK, Hong WS, Kim JH, Min YI
- KMID: 2439744
- Korean J Gastroenterol.
- 2005 Feb;45(2):103-110.
BACKGROUND/AIMS: Glucocorticoid resistance poses a challenging clinical problem in inflammatory bowel disease because more than one fourth of patients with severe ulcerative colitis do not respond to anti-inflammatory steroids.... -
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- PMA-induced up-regulation of MMP-9 is regulated by a PKCalpha-NF-kappaB cascade in human lung epithelial cells
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Shin YH, Yoon SH, Choe EY, Cho SH, Woo CH, Rho JY, Kim JH
- KMID: 1103685
- Exp Mol Med.
- 2007 Feb;39(1):97-105.
Expression of matrix metalloproteinase-9 (MMP-9) is associated with airway remodeling and tissue injury in asthma. However, little is known about how MMP-9 is up-regulated in airway epithelial cells. In this... -
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- alpha-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-kappaB in H. pylori-Infected Gastric Epithelial AGS Cells
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Choi JH, Cho SO, Kim H
- KMID: 2466379
- Yonsei Med J.
- 2016 Jan;57(1):260-264.
- doi: 10.3349/ymj.2016.57.1.260
The epithelial cytokine response, associated with reactive oxygen species (ROS), is important in Helicobacter pylori (H. pylori)-induced inflammation. H. pylori induces the production of ROS, which may be involved in... -
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- Effect of Aspirin on the Expression of Hepatocyte NF-kappaB and Serum TNF-alpha in Streptozotocin-Induced Type 2 Diabetic Rats
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Sun X, Han F, Yi J, Han L, Wang B
- KMID: 1785962
- J Korean Med Sci.
- 2011 Jun;26(6):765-770.
- doi: 10.3346/jkms.2011.26.6.765
Aspirin is a kind of anti-inflammatory drug and may be used to reverse hyperglycemia, hyperinsulinemia, and dyslipidemia by improving insulin resistance. We hypothesized that aspirin improves insulin resistance in type... -
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- Extracellular HIV-1 Tat enhances monocyte adhesion by up-regulation of ICAM-1 and VCAM-1 gene expression via ROS-dependent NF-kappaB activation in astrocytes
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Song HY, Ryu J, Ju SM, Park LJ, Lee JA, Choi SY, Park J
- KMID: 1103678
- Exp Mol Med.
- 2007 Feb;39(1):27-37.
One of characteristic features of AIDS-related encephalitis and dementia is the infiltration of monocytes into the CNS. HIV-1 Tat was demonstrated to facilitate monocyte entry into the CNS. In this... -
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- Regulation of B cell activating factor (BAFF) receptor expression by NF-kappaB signaling in rheumatoid arthritis B cells
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Woo YJ, Yoon BY, Jhun JY, Oh HJ, Min S, Cho ML, Park SH, Kim HY, Min JK
- KMID: 1107376
- Exp Mol Med.
- 2011 Jun;43(6):350-357.
- doi: 10.3858/emm.2011.43.6.038
B cells play an important role in the pathogenesis of rheumatoid arthritis (RA). High levels of B cell activating factor (BAFF) are detected in autoimmune diseases. BAFF and BAFF receptor... -
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- NF-kappaB and CREB Are Involved in IL-8 Production of Human Neutrophils Induced by Trichomonas vaginalis-Derived Secretory Products
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Nam YH, Min D, Park SJ, Kim KA, Lee YA, Shin MH
- KMID: 1715654
- Korean J Parasitol.
- 2011 Sep;49(3):291-294.
- doi: 10.3347/kjp.2011.49.3.291
Trichomonas vaginalis is a flagellated lumen-dwelling extracellular protozoan parasite that causes human trichomoniasis via sexual intercourse. Human neutrophils play a crucial role in acute tissue inflammatory responses in T. vaginalis... -
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- Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
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Lim JH, Um HJ, Park JW, Lee IK, Kwon TK
- KMID: 1009397
- Exp Mol Med.
- 2009 Oct;41(10):757-764.
- doi: 10.3858/emm.2009.41.10.082
Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this... -
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- Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappa B activation
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Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, Lv N, Ka SO, Yeom SR, Kwon YD, Ryu DG, Kim KS, Park JW, Park R, Park BH
- KMID: 1094655
- Exp Mol Med.
- 2007 Apr;39(2):149-159.
We demonstrated previously that Coptidis rhizoma extract (CRE) prevented S-nitroso-N-acetylpenicillamine-induced apoptotic cell death via the inhibition of mitochondrial membrane potential disruption and cytochrome c release in RINm5F (RIN) rat insulinoma... -
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- alpha-Lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activity
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Kim HS, Kim HJ, Park KG, Kim YN, Kwon TK, Park JY, Lee KU, Kim JG, Lee IK
- KMID: 1103686
- Exp Mol Med.
- 2007 Feb;39(1):106-113.
The migration of vascular smooth muscle cells (VSMCs) into the intima, an important step in injury-induced neointimal hyperplasia, requires the activation of nuclear factor-kappaB (NF-kappaB) and the consequent up-regulation of... -
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- Neutrophil Elastase Causes MUC5AC Mucin Synthesis Via EGF Receptor, ERK and NF-kB Pathways in A549 Cells
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Song JS, Cho KS, Yoon HK, Moon HS, Park SH
- KMID: 1115250
- Korean J Intern Med.
- 2005 Dec;20(4):275-283.
- doi: 10.3904/kjim.2005.20.4.275
BACKGROUND: Neutrophil elastase (NE) was found to increase the respiratory mucin gene, MUC5AC, although the molecular mechanisms of this process remain unknown. We attempted to determine the signal transduction pathway... -
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- Extracellular HIV-1 Tat up-regulates expression of matrix metalloproteinase-9 via a MAPK-NF-kappaB dependent pathway in human astrocytes
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Ju SM, Song HY, Lee JA, Lee SJ, Choi SY, Park J
- KMID: 1109431
- Exp Mol Med.
- 2009 Feb;41(2):86-93.
- doi: 10.3858/emm.2009.41.2.011
The infiltration of monocytes into the CNS represents one of the early steps to inflammatory events in AIDS-related encephalitis and dementia. Increased activity of selected matrix metalloproteinases (MMPs) such as... -
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- NF-kappaB is involved in the TNF-alpha induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARg expression
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Chae GN, Kwak SJ
- KMID: 1093616
- Exp Mol Med.
- 2003 Oct;35(5):431-437.
TNF-alpha, a trimeric cytokine, was known to inhibit differention of preadipocytes to adipocytes. In the present study, we investigated signal mediators working downstream of TNF-alpha using murine 3T3-L1 cells. TNF-alpha... -
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- Toxoplasma gondi Inhibits Apoptosis in Infected Cells by Caspase Inactivation and NF-kappaB Activation
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Kim JY, Ahn MH, Jun HS, Jung JW, Ryu JS, Min DY
- KMID: 1777177
- Yonsei Med J.
- 2006 Dec;47(6):862-869.
- doi: 10.3349/ymj.2006.47.6.862
Our experiments aimed to clarify the mechanism by which host cell apoptosis is inhibited by infection with the intracellular protozoan parasite, Toxoplasma gondii (T. gondii). Mouse spleen cells were cultured... -
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- A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha
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Lee KS, Kim SR, Park HS, Park SJ, Min KH, Lee KY, Choe YH, Hong SH, Han HJ, Lee YR, Kim JS, Atlas D, Lee YC
- KMID: 1091070
- Exp Mol Med.
- 2007 Dec;39(6):756-768.
Reactive oxygen species (ROS) play an important role in the pathogenesis of airway inflammation and hyperresponsiveness. Recent studies have demonstrated that antioxidants are able to reduce airway inflammation and hyperreactivity... -
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- Sulfuretin protects against cytokine-induced beta-cell damage and prevents streptozotocin-induced diabetes
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Song MY, Jeong GS, Kwon KB, Ka SO, Jang HY, Park JW, Kim YC, Park BH
- KMID: 983955
- Exp Mol Med.
- 2010 Sep;42(9):628-638.
- doi: 10.3858/emm.2010.42.9.062
NF-kappaB activation has been implicated as a key signaling mechanism for pancreatic beta-cell damage. Sulfuretin is one of the main flavonoids produced by Rhus verniciflua, which is reported to inhibit... -
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