Exp Mol Med.
2008 Feb;40(1):52-58. 10.3858/emm.2008.40.1.52.
Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB
- Affiliations
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- 1Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Korea. hschoi@mail.ulsan.ac.kr
- KMID: 1103588
- DOI: http://doi.org/10.3858/emm.2008.40.1.52
Abstract
- Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-alpha Rutin also lowers NF-kappaB activation in response to RANKL.
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