- Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB
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Kyung TW, Lee JE, Shin HH, Choi HS
- KMID: 1103588
- Exp Mol Med.
- 2008 Feb;40(1):52-58.
- doi: 10.3858/emm.2008.40.1.52
Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its... -
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- Withaferin A-Caused Production of Intracellular Reactive Oxygen Species Modulates Apoptosis via PI3K/Akt and JNKinase in Rabbit Articular Chondrocytes
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Yu SM, Kim SJ
- KMID: 2129597
- J Korean Med Sci.
- 2014 Aug;29(8):1042-1053.
- doi: 10.3346/jkms.2014.29.8.1042
Withaferin A (WFA) is known as a constituent of Ayurvedic medicinal plant, Withania somnifera, and has been used for thousands of years. Although WFA has been used for the treatment... -
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- Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos
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Ali I, Shah SZ, Jin Y, Li ZS, Ullah O, Fang NZ
- KMID: 2412581
- J Vet Sci.
- 2017 Mar;18(1):1-9.
- doi: 10.4142/jvs.2017.18.1.1
Excessive production of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress-mediated responses are critical to embryonic development in the challenging in vitro environment. ROS production increases during early embryonic... -
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- TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts
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Park ES, Kim J, Ha TU, Choi JS, Hong KS, Rho J
- KMID: 2154254
- Exp Mol Med.
- 2013 Aug;45(8):e35.
Apoptosis has an important role in maintaining tissue homeostasis in cellular stress responses such as inflammation, endoplasmic reticulum stress, and oxidative stress. T-cell death-associated gene 51 (TDAG51) is a member... -
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- Expression of Autophagy and Reactive Oxygen Species-Related Proteins in Lacrimal Gland Adenoid Cystic Carcinoma
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Koo JS, Kim JW, Yoon JS
- KMID: 2374057
- Yonsei Med J.
- 2016 Mar;57(2):482-489.
- doi: 10.3349/ymj.2016.57.2.482
PURPOSE: To investigate the difference of expression of autophagy and reactive oxygen species (ROS) related proteins in adenoid cystic carcinoma (ACC) of lacrimal gland in comparison with ACC of salivary... -
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- IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species
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Paek AR, Kim SH, Kim SS, Kim KT, You HJ
- KMID: 964664
- Exp Mol Med.
- 2010 Oct;42(10):696-702.
- doi: 10.3858/emm.2010.42.10.068
Expression of zinc-finger protein 143 (ZNF143), a human homolog of the Xenopus transcriptional activator protein Staf, is induced by various DNA-damaging agents including etoposide, doxorubicin, and gamma-irradiation. ZNF143 binds to... -
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- Oxidative Stress in Vivax Malaria
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Bilgin R, Yalcin MS, Yucebilgic G, Koltas IS, Yazar S
- KMID: 1792135
- Korean J Parasitol.
- 2012 Dec;50(4):375-377.
Malaria is still a leading cause of morbidity and mortality. The increase in lipid peroxidation reported in malaria infection and antioxidant status may be a useful marker of oxidative stress... -
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- Sulforaphane Induces Antioxidative and Antiproliferative Responses by Generating Reactive Oxygen Species in Human Bronchial Epithelial BEAS-2B Cells
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Lee YJ, Lee SH
- KMID: 1123448
- J Korean Med Sci.
- 2011 Nov;26(11):1474-1482.
- doi: 10.3346/jkms.2011.26.11.1474
Sulforaphane (SFN) is a naturally occurring compound which is known to induce the phase II antioxidant genes via Nrf2 activation, although the underlying mechanism has not been fully elucidated. In... -
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- Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1
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Park DW, Baek K, Kim JR, Lee JJ, Ryu SH, Chin BR, Baek SH
- KMID: 1123464
- Exp Mol Med.
- 2009 Mar;41(3):171-179.
- doi: 10.3858/emm.2009.41.3.020
Resveratrol is a polyphenolic compound in red wine that has anti-oxidant and cardioprotective effects in animal models. Reactive oxygen species (ROS) and monocyte chemotactic protein-1 (MCP-1) play key roles in... -
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- Mitochondrial and DNA damage in bovine somatic cell nuclear transfer embryos
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Hwang IS, Bae HK, Cheong HT
- KMID: 1705552
- J Vet Sci.
- 2013 Sep;14(3):235-240.
- doi: 10.4142/jvs.2013.14.3.235
The generation of reactive oxygen species (ROS) and subsequent mitochondrial and DNA damage in bovine somatic cell nuclear transfer (SCNT) embryos were examined. Bovine enucleated oocytes were electrofused with donor... -
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- N-acetylcysteine protects against cadmium-induced oxidative stress in rat hepatocytes
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Wang J, Zhu H, Liu X, Liu Z
- KMID: 2070234
- J Vet Sci.
- 2014 Dec;15(4):485-493.
- doi: 10.4142/jvs.2014.15.4.485
Cadmium (Cd) is a well-known hepatotoxic environmental pollutant. We used rat hepatocytes as a model to study oxidative damage induced by Cd, effects on the antioxidant systems, and the role... -
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- Microglial P2X7 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease
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Lee HG, Won SM, Gwag BJ, Lee YB
- KMID: 991618
- Exp Mol Med.
- 2011 Jan;43(1):7-14.
- doi: 10.3858/emm.2011.43.1.001
The possibility that P2X7 receptor (P2X7R) expression in microglia would mediate neuronal damage via reactive oxygen species (ROS) production was examined in the APPswe/PS1dE9 mouse model of Alzheimer's disease (AD).... -
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- Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
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Yun JH, Park SJ, Jo A, Kang JL, Jou I, Park JS, Choi YH
- KMID: 1058703
- Exp Mol Med.
- 2011 Dec;43(12):660-668.
- doi: 10.3858/emm.2011.43.12.075
Recent evidence supports a neuroprotective role of Src homology 2-containing protein tyrosine phosphatase 2 (SHP-2) against ischemic brain injury. However, the molecular mechanisms of SHP-2 activation and those governing how... -
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- Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species
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Moon HJ, Kim SE, Yun YP, Hwang YS, Bang JB, Park JH, Kwon IK
- KMID: 1025163
- Exp Mol Med.
- 2011 Nov;43(11):605-612.
- doi: 10.3858/emm.2011.43.11.067
Osteoclasts, together with osteoblasts, control the amount of bone tissue and regulate bone remodeling. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. Reactive oxygen... -
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- ATP released from beta-amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion
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Kim SY, Moon JH, Lee HG, Kim SU, Lee YB
- KMID: 1091077
- Exp Mol Med.
- 2007 Dec;39(6):820-827.
Present study demonstrated that fibrillar beta-amyloid peptide (fAbeta(1-42)) induced ATP release, which in turn activated NADPH oxidase via the P2X(7) receptor (P2X(7)R). Reactive oxygen species (ROS) production in fAbeta(1-42)-treated microglia... -
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- Inhibition of rac1 Reduces PDGF-induced Reactive Oxygen Species and Proliferation in Vascular Smooth Muscle Cells
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Kong G, Lee S, Kim KS
- KMID: 648350
- J Korean Med Sci.
- 2001 Dec;16(6):712-718.
- doi: 10.3346/jkms.2001.16.6.712
In vascular smooth muscle cells, reactive oxygen species (ROS) were known to mediate platelet-derived growth factor (PDGF)-induced cell proliferation and NADH/NADPH oxidase is the major source of ROS. NADH/NADPH oxidase... -
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- Extracellular HIV-1 Tat enhances monocyte adhesion by up-regulation of ICAM-1 and VCAM-1 gene expression via ROS-dependent NF-kappaB activation in astrocytes
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Song HY, Ryu J, Ju SM, Park LJ, Lee JA, Choi SY, Park J
- KMID: 1103678
- Exp Mol Med.
- 2007 Feb;39(1):27-37.
One of characteristic features of AIDS-related encephalitis and dementia is the infiltration of monocytes into the CNS. HIV-1 Tat was demonstrated to facilitate monocyte entry into the CNS. In this... -
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- Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes
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Kim NH, Hong BK, Choi SY, Moo Kwon H, Cho CS, Yi EC, Kim WU
- KMID: 2154251
- Exp Mol Med.
- 2013 Jul;45(7):e32.
The activation of nuclear factor of activated T cells 5 (NFAT5), a well-known osmoprotective factor, can be induced by isotonic stimuli, such as activated Toll-like receptors (TLRs). It is unclear,... -
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- Quercetin improves the in vitro development of porcine oocytes by decreasing reactive oxygen species levels
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Kang JT, Kwon DK, Park SJ, Kim SJ, Moon JH, Koo OJ, Jang G, Lee BC
- KMID: 1482808
- J Vet Sci.
- 2013 Mar;14(1):15-20.
- doi: 10.4142/jvs.2013.14.1.15
Quercetin is a plant-derived flavonoid found in fruits or vegetables that has antioxidant properties and acts as a free radical scavenger. We investigated the effects of quercetin on porcine oocyte... -
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- Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar beta amyloid peptide (1-42)-stimulated microglia
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Moon JH, Kim SY, Lee HG, Kim SU, Lee YB
- KMID: 1103583
- Exp Mol Med.
- 2008 Feb;40(1):11-18.
- doi: 10.3858/emm.2008.40.1.11
Recent studies have reported that the "cholinergic anti-inflammatory pathway" regulates peripheral inflammatory responses via alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) and that acetylcholine and nicotine regulate the expression of proinflammatory... -
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