- Involvement of NOX2-derived ROS in human hepatoma HepG2 cell death induced by Entamoeba histolytica
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Lee YA, Shin MH
- KMID: 2548515
- Parasit Host Dis.
- 2023 Nov;61(4):388-396.
- doi: 10.3347/PHD.23094
Entamoeba histolytica is an enteric tissue-invasive protozoan parasite causing amoebic colitis and liver abscesses in humans. Amoebic contact with host cells activates intracellular signaling pathways that lead to host cell... -
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- Domperidone Exerts Antitumor Activity in Triple-Negative Breast Cancer Cells by Modulating Reactive Oxygen Species and JAK/STAT3 Signaling
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Shakya R, Byun MR, Joo SH, Chun KS, Choi JS
- KMID: 2547502
- Biomol Ther.
- 2023 Nov;31(6):692-699.
- doi: 10.4062/biomolther.2023.173
The lack of molecular targets hampers the treatment of triple-negative breast cancer (TNBC). In this study, we determined the cytotoxicity of domperidone, a dopamine D2 receptor (DRD2) antagonist in human... -
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- Niclosamide Inhibits Aortic Valve Interstitial Cell Calcification by Interfering with the GSK-3β/β-Catenin Signaling Pathway
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Adhikari R, Shiwakoti S, Kim E, Choi IJ, Park SH, Ko JY, Chang K, Oak MH
- KMID: 2545708
- Biomol Ther.
- 2023 Sep;31(5):515-525.
- doi: 10.4062/biomolther.2022.146
The most common heart valve disorder is calcific aortic valve stenosis (CAVS), which is characterized by a narrowing of the aortic valve. Treatment with the drug molecule, in addition to... -
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- D-Galactose and Hypoxia Induce the Early Onset of Age-Related Hearing Loss Deterioration in a Mouse Model
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Temuulen T, Choi JS, Ha SM, Ahn Y, Seo YJ
- KMID: 2545057
- Tissue Eng Regen Med.
- 2023 Aug;20(5):779-787.
- doi: 10.1007/s13770-023-00547-8
BACKGROUND: We previously showed that aging accelerates after 3 months of exposure to hypoxia and environmental change but not genetic modifications. Here, we aimed to simply induce early-onset age-related hearing... -
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- Lipid emulsion inhibits the cardiac toxicity caused by chloroquine via inhibition of reactive oxygen species production
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Lee SH, Ok SH, Ahn SH, Sim G, Kim HJ, Kim M, Yoon S, Sohn JT
- KMID: 2544556
- Korean J Anesthesiol.
- 2023 Aug;76(4):368-382.
- doi: 10.4097/kja.22572
Background: Lipid emulsion (LE) is effective in treating intractable cardiac depression induced by the toxicity of highly lipid-soluble drugs including local anesthetics. However, the effect of LE on chloroquine (CQ)-evoked... -
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- Antisense oligodeoxynucleotides against dynamin-related protein 1 reduce remifentanilinduced hyperalgesia by modulating spinal N-methyl-D-aspartate receptor expression in rats
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Zhou S, Pan Y, Zhang Y, Gu L, Ma L, Xu Q, Wang W, Sun J
- KMID: 2544243
- Korean J Pain.
- 2023 Jul;36(3):316-327.
- doi: 10.3344/kjp.22398
Background: Spinal N-methyl-D-aspartate (NMDA) receptor activation is attributed to remifentanil-induced hyperalgesia (RIH). However, the specific mechanism and subsequent treatment is still unknown. Previous studies have shown that the dynamin-related protein... -
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- Dihydroaustrasulfone alcohol induces apoptosis in nasopharyngeal cancer cells by inducing reactive oxygen speciesdependent inactivation of the PI3K/AKT pathway
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Tan KT, Shih YH, Gong JY, Zhang X, Huang CY, Su JH, Sheu JH, Lin CC
- KMID: 2544140
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):383-398.
- doi: 10.4196/kjpp.2023.27.4.383
Dihydroaustrasulfone alcohol (DA), the synthetic precursor of a natural compound (austrasulfone) isolated from the coral species Cladiella australis, has shown cytotoxic effects against cancer cells. However, it is unknown whether... -
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- Curcumin Enhances the Anticancer Effects of Binimetinib on Melanoma Cells by Inducing Mitochondrial Dysfunction and Cell Apoptosis with Necroptosis
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Lee YJ, Heo JY, Kim DS, Choi YS, Kim S, Nam HS, Lee SH, Cho MK
- KMID: 2542656
- Ann Dermatol.
- 2023 Jun;35(3):217-228.
- doi: 10.5021/ad.22.200
Background: Recent studies suggest that MEK1/2 inhibitors, including binimetinib, significantly improve malignant melanoma (MM) patient survival. Growing evidence suggests that phytochemicals, especially curcumin, can overcome drug resistance in cancer cells... -
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- Mitochondrial Ribosomal Protein L14 Promotes Cell Growth and Invasion by Modulating Reactive Oxygen Species in Thyroid Cancer
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Kim HJ, Nguyen QK, Jung SN, Lim MA, Oh C, Piao Y, Jin Y, Kim JH, Kim YI, Kang YE, Chang JW, Won HR, Koo BS
- KMID: 2542360
- Clin Exp Otorhinolaryngol.
- 2023 May;16(2):184-197.
- doi: 10.21053/ceo.2022.01760
Objectives. The mitochondrial ribosomal protein L14 (MRPL14) is encoded by a nuclear gene and participates in mitochondrial protein translation. In this study, we aimed to investigate the role of MRPL14... -
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- Inhibition of Fatty Acid β-Oxidation by Fatty Acid Binding Protein 4 Induces Ferroptosis in HK2 Cells Under High Glucose Conditions
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Chen J, Wu K, Lei Y, Huang M, Cheng L, Guan H, Lin J, Zhong M, Wang X, Zheng Z
- KMID: 2541879
- Endocrinol Metab.
- 2023 Apr;38(2):226-244.
- doi: 10.3803/EnM.2022.1604
Background: Ferroptosis, which is caused by an iron-dependent accumulation of lipid hydroperoxides, is a type of cell death linked to diabetic kidney disease (DKD). Previous research has shown that fatty... -
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- Antioxidant effect of ergothioneine on in vitro maturation of porcine oocytes
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Jeong JY, Cai L, Kim M, Choi H, Oh D, Jawad A, Kim S, Zheng H, Lee E, Lee J, Hyun SH
- KMID: 2541341
- J Vet Sci.
- 2023 Mar;24(2):e24.
- doi: 10.4142/jvs.22204
Background: Ergothioneine (EGT) is a natural amino acid derivative in various animal organs and is a bioactive compound recognized as a food and medicine. Objectives: This study examined the effects of... -
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- Recent Advances in ROS-Scavenging Metallic Nanozymes for Anti-Inflammatory Diseases: A Review
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Mohapatra A, Park IK
- KMID: 2538692
- Chonnam Med J.
- 2023 Jan;59(1):13-23.
- doi: 10.4068/cmj.2023.59.1.13
Oxidative stress and dysregulated inflammatory responses are the hallmarks of inflammatory disorders, which are key contributors to high mortality rates and impose a substantial economic burden on society. Reactive oxygen... -
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- MS-5, a Naphthalene Derivative, Induces Apoptosis in Human Pancreatic Cancer BxPC-3 Cells by Modulating Reactive Oxygen Species
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Giri S, Park GH, Choi JS, Ma E, Chun KS, Joo SH
- KMID: 2537582
- Biomol Ther.
- 2023 Jan;31(1):68-72.
- doi: 10.4062/biomolther.2022.127
Pancreatic cancer is one of the most fatal cancers with a poor prognosis. Standard chemotherapies have proven largely ineffective because of their toxicity and the development of resistance. Therefore, there... -
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- Antibacterial properties of dental resin incorporated with nano-silver doped silica in accordance with exposure of visible light
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Lee MY, Yoon HW, Kim KM, Kwon JS
- KMID: 2537864
- Korean J Dent Mater.
- 2022 Dec;49(4):161-172.
- doi: 10.14815/kjdm.2022.49.4.161
This study investigated reduction of the bandgap of silica by applying nano-silver doping technique and possible application of such silica as a filler in dental resin. Due to reduce band... -
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- Oxidative Stress and Its Relation to Lower Urinary Tract Symptoms
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Andersson KE
- KMID: 2537302
- Int Neurourol J.
- 2022 Dec;26(4):261-267.
- doi: 10.5213/inj.2244190.095
The aim of this review is to discuss how to link lower urinary tract symptoms (LUTS) and oxidative stress (OS) and to define relevant targets for therapeutic intervention. Narrative review... -
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- Clinical effectiveness and prospects of methylene blue: A systematic review
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Seitkazina A, Yang JK, Kim S
- KMID: 2538084
- Precis Future Med.
- 2022 Dec;6(4):193-208.
- doi: 10.23838/pfm.2022.00079
Methylene blue (MB) is a well-known pharmaceutical ingredient that is thought to have a multi-targeted therapeutic effect as an anti-malarial and neuroprotective agent and has recently been identified as a... -
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- Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling
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Shakya R, Park GH, Joo SH, Shim JH, Choi JS
- KMID: 2534709
- Biomol Ther.
- 2022 Nov;30(6):585-592.
- doi: 10.4062/biomolther.2022.121
Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist... -
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- Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance
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Chun KS, Joo SH
- KMID: 2534697
- Biomol Ther.
- 2022 Nov;30(6):479-489.
- doi: 10.4062/biomolther.2022.017
5-Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5-FU, and new strategies are required... -
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- Pathomechanism of oxidative stress in cardiovascularrenal remodeling and therapeutic strategies
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Ravarotto V, Bertoldi G, Stefanelli LF, Nalesso F, Calò LA
- KMID: 2535399
- Kidney Res Clin Pract.
- 2022 Sep;41(5):533-544.
- doi: 10.23876/j.krcp.22.069
The high prevalence of cardiovascular disease in patients with chronic kidney disease indicates significant interactions between pathogenic pathways operating in the kidney and heart. These interactions involve all cell types... -
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- The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review
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Amini MA, Karimi M, Talebi SS, Piri H, Karimi J
- KMID: 2533273
- Chonnam Med J.
- 2022 Sep;58(3):91-95.
- doi: 10.4068/cmj.2022.58.3.91
Infertility is one of the disorders that worries many couples around the world, although novel and molecular methods can be used to cure this disease in different stages. One of... -
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