- Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCalpha-ERK pathway
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Park MH, Lee DH
- KMID: 1103592
- Exp Mol Med.
- 2008 Feb;40(1):92-97.
- doi: 10.3858/emm.2008.40.1.92
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and... -
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- Exposure to Cerium Oxide Nanoparticles Is Associated With Activation of Mitogen-activated Protein Kinases Signaling and Apoptosis in Rat Lungs
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Rice KM, Nalabotu S, Manne ND, Kolli MB, Nandyala G, Arvapalli , Ma JY, Blough ER
- KMID: 2381462
- J Prev Med Public Health.
- 2015 May;48(3):132-141.
- doi: 10.3961/jpmph.15.006
OBJECTIVES: With recent advances in nanoparticle manufacturing and applications, potential exposure to nanoparticles in various settings is becoming increasing likely. No investigation has yet been performed to assess whether respiratory... -
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- ERK-1/-2 and p38 Kinase Oppositely Regulate 15-deoxy-delta(12,14)-prostaglandinJ2-Induced PPAR-gamma Activation That Mediates Dedifferentiation But Not Cyclooxygenase-2 Expression in Articular Chondrocytes
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Yoon EK, Lee WK, Lee JH, Yu SM, Hwang SG, Kim SJ
- KMID: 1785763
- J Korean Med Sci.
- 2007 Dec;22(6):1015-1021.
- doi: 10.3346/jkms.2007.22.6.1015
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a ligand-activated transcription factor and plays an important role in growth, differentiation, and inflammation in different tissues. In this study, we investigated the effects... -
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- CD137 induces adhesion and cytokine production in human monocytic THP-1 cells
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Choi JW, Lee HW, Roh GS, Kim HH, Kwack KB
- KMID: 755745
- Exp Mol Med.
- 2005 Apr;37(2):78-85.
CD137, which is expressed on activated T cells, plays a critical role in inflammatory responses. However, the exact role that CD137 plays in monocytes is not fully known. Here we... -
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- Cilostazol Protects Endothelial Cells Against Lipopolysaccharide-Induced Apoptosis Through ERK1/2- and P38 MAPK-Dependent Pathways
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Lim JH, Woo JS, Shin YW
- KMID: 1717961
- Korean J Intern Med.
- 2009 Jun;24(2):113-122.
- doi: 10.3904/kjim.2009.24.2.113
BACKGROUND/AIMS: We examined the effects of cilostazol on mitogen-activated protein kinase (MAPK) activity and its relationship with cilostazol-mediated protection against apoptosis in lipopolysaccharide (LPS)-treated endothelial cells. METHODS: Human umbilical vein... -
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- Inhibitory effect of Hsp70 on angiotensin II-induced vascular smooth muscle cell hypertrophy
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Zheng Y, Im CN, Seo JS
- KMID: 1098085
- Exp Mol Med.
- 2006 Oct;38(5):509-518.
Angiotensin II (Ang II), which is an important mediator of both vascular responsiveness and growth, has been shown to induce vascular smooth muscle cell (VSMC) hypertrophy via the activation of... -
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- Expression and Regulation of Endothelial Nitric Oxide Synthase by Vascular Endothelial Growth Factor in ECV 304 Cells
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Park JS, Hong GR, Baek SW, Shin DG, Kim YJ, Shim BS
- KMID: 648670
- J Korean Med Sci.
- 2002 Apr;17(2):161-167.
- doi: 10.3346/jkms.2002.17.2.161
Nitric oxide (NO) seems to play a pivotal role in the vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation. This study was designed to investigate the role and intracellular signal... -
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- Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN-induced matrix metalloproteinase-9 expression
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Lim EJ, Lee SH, Lee JG, Kim JR, Yun SS, Baek SH, Lee C
- KMID: 1094665
- Exp Mol Med.
- 2007 Apr;39(2):239-245.
Unmethylated CpG oligodeoxynucleotides (CpG ODNs) activate immune cells to produce immune mediators. This study demonstrates that in murine macrophage RAW 264.7 cells, CpG ODN-mediated matrix metalloproteinase-9 (MMP-9) expression is regulated... -
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- Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways
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Kim SJ, Jeong CW, Bae HB, Kwak SH, Son JK, Seo CS, Lee HJ, Lee J, Yoo KY
- KMID: 1372805
- J Korean Med Sci.
- 2012 May;27(5):572-575.
- doi: 10.3346/jkms.2012.27.5.572
Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of... -
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- Activated Protein C Protects Myocardium Via Activation of Anti-apoptotic Pathways of Survival in Ischemia-reperfused Rat Heart
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Ding JW, Tong XH, Yang J, Liu ZQ, Zhang Y, Yang J, Li S, Li L
- KMID: 1779231
- J Korean Med Sci.
- 2010 Nov;25(11):1609-1615.
- doi: 10.3346/jkms.2010.25.11.1609
Activated protein C (APC) is known to be beneficial on ischemia reperfusion injury in myocardium. However, the protection mechanism of APC is not fully understood. The purpose of this study... -
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- Effects of Scutellarin on MUC5AC Mucin Production Induced by Human Neutrophil Elastase or Interleukin 13 on Airway Epithelial Cells
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Jiang DP, Perelman J, Kolosov VP, Zhou XD
- KMID: 1785964
- J Korean Med Sci.
- 2011 Jun;26(6):778-784.
- doi: 10.3346/jkms.2011.26.6.778
Scutellarin is a flavonoid extracted from a traditional Chinese herb, Erigeron breviscapus. The present study investigated the effect of scutellarin on MUC5AC mucin production and the possible mechanism. Human bronchial... -
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- Bilirubin Activates Transcription of HIF-1alpha in Human Proximal Tubular Cells Cultured in the Physiologic Oxygen Content
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Kim SG, Ahn SY, Lee ES, Kim S, Na KY, Chae DW, Chin HJ
- KMID: 2069806
- J Korean Med Sci.
- 2014 Sep;29(Suppl 2):S146-S154.
- doi: 10.3346/jkms.2014.29.S2.S146
The expression of hypoxia-inducible factor (HIF) is influenced by reactive oxygen species (ROS). Effect of bilirubin on HIF-1 expression in proximal tubular cells was investigated under physiological oxygen concentration, which... -
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- PKC alpha induces differentiation through ERK1/2 phosphorylation in mouse keratinocytes
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Seo HR, Kwan YW, Cho CK, Bae S, Lee SJ, Soh JW, Chung HY, Lee YS
- KMID: 1094073
- Exp Mol Med.
- 2004 Aug;36(4):292-299.
Epidermal keratinocyte differentiation is a tightly regulated stepwise process that requires protein kinase C (PKC) activation. Studies on cultured mouse keraitnocytes induced to differentiate with Ca2+ have indirectly implicated the... -
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- p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells
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Ko J, Yun CY, Lee JS, Kim JH, Kim IS
- KMID: 1094653
- Exp Mol Med.
- 2007 Apr;39(2):129-138.
9-cis-retinoic acid (9CRA) plays an important role in the immune response; this includes cytokine production and cell migration. We have previously demonstrated that 9CRA increases expression of chemokine receptors CCR1... -
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- Calcitonin induces connective tissue growth factor through ERK1/2 signaling in renal tubular cells
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Nakamura M, Ozaki T, Ishii A, Konishi M, Tsubota Y, Furui T, Tsuda H, Mori I, Ota K, Kakudo K
- KMID: 1123804
- Exp Mol Med.
- 2009 May;41(5):307-314.
- doi: 10.3858/emm.2009.41.5.034
Calcitonin (CT), a polypeptide hormone, plays important roles in a variety of physiological processes. CT has been used clinically to treat osteoporosis and humoral hypercalcemia of malignancy. In order to... -
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- Genes Involved in Neurodevelopment, Neuroplasticity and Major Depression: No Association for CACNA1C, CHRNA7 and MAPK1
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Calabrò M, Mandelli L, Crisafulli C, Lee SJ, Jun TY, Wang SM, Patkar AA, Masand PS, Han C, Pae CU, Serretti A
- KMID: 2457399
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):364-368.
- doi: 10.9758/cpn.2019.17.3.364
OBJECTIVE: Genetics factors are likely to play a role in the risk, clinical presentation and treatment outcome in major depressive disorder (MDD). In this study, we investigated the role of... -
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- Antiangiogenic Activity of Acer tegmentosum Maxim Water Extract in Vitro and in Vivo
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Kim EC, Kim SH, Piao SJ, Kim TJ, Bae K, Kim HS, Hong SS, Lee BI, Nam M
- KMID: 2164486
- J Korean Med Sci.
- 2015 Jul;30(7):979-987.
- doi: 10.3346/jkms.2015.30.7.979
Angiogenesis, the formation of new blood vessels, is critical for tumor growth and metastasis. Notably, tumors themselves can lead to angiogenesis by inducing vascular endothelial growth factor (VEGF), which is... -
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- Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model
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Choi Y, Park SK, Kim HM, Kang JS, Yoon YD, Han SB, Han JW, Yang JS, Han G
- KMID: 1104812
- Exp Mol Med.
- 2008 Oct;40(5):574-581.
- doi: 10.3858/emm.2008.40.5.574
In light of the anti-inflammatory properties of histone deacetylase (HDAC) inhibitors, such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), we examined a new HDAC inhibitor KBH-A42 for its... -
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