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Application of Mitochondrial Morphology for Diagnosis of Steroidogenous Cell Origin Tumor: on the basis of the primary and the metastatic ovarian tumors

Lim SC, Seo JH

  • KMID: 2329132
  • J Korean Cancer Assoc.
  • 1998 Apr;30(2):402-413.
PURPOSE: The purpose of this study is to evaluate the diagnostic availability of the morphology of mitochondria to identify the nature or the origin of neoplasms. MATRIALS AND METHODS: We...
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Radiolabeled Phosphonium Salts as Mitochondrial Voltage Sensors for Positron Emission Tomography Myocardial Imaging Agents

Kim DY, Min JJ

Despite substantial advances in the diagnosis of cardiovascular disease, ¹⁸F-labeled positron emission tomography (PET) radiopharmaceuticals remain necessary to diagnose heart disease because clinical use of current PET tracers is limited...
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Effect of Ginsenosides on the Lipid Distribution in Rat Tissues

Kim JY, Kim KS, Seo YY, Song DU, Jung YD, Ahn BW, Yang SY

  • KMID: 2048568
  • Chonnam Med J.
  • 1998 Dec;34(2):255-265.
The effect of total ginsenosides on the composition and peroxidation of lipids in sera and biomembranes of rats fed high cholesterol diet was studied. Male Wistar rats were divided into...
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Synthesis of (4-[18F]Fluorophenyl)triphenylphosphonium as a Mitochondrial Voltage Sensor for PET

Kim DY, Yu KH, Bom HS, Min JJ

  • KMID: 1910722
  • Nucl Med Mol Imaging.
  • 2007 Dec;41(6):561-565.
PURPOSE: Lipophilic cations including tetraphenylphosphonium (TPP) salts penetrate the hydrophobic barriers of the plasma and mitochondrial membranes, resulting in accumulation in mitochondria in response to the negative inner transmembrane potentials....
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Mitochondrial Reactive Oxygen Species Production Mediated by Romo1 Expression

Yoo YD

Release of reactive oxygen species (ROS) generated in the mitochondria to the cytosol is well controlled by various proteins in order to maintain and regulate redox homeostasis and cellular signaling...
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A Computational Model of Cytosolic and Mitochondrial [Ca2+] in Paced Rat Ventricular Myocytes

Youm JB, Choi SW, Jang CH, Kim HK, Leem CH, Kim N, Han J

We carried out a series of experiment demonstrating the role of mitochondria in the cytosolic and mitochondrial Ca2+ transients and compared the results with those from computer simulation. In rat...
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Immunostimulatory Effects of Silica Nanoparticles in Human Monocytes

Yang EJ, Choi IH

Amorphous silica particles, whose applications are increasing in many biomedical fields, are known to be less toxic than crystalline silica. In this study, the inflammatory effects of amorphous silica nanoparticles...
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Promoting Effect of Hydrogen Peroxide on 1-Methyl-4-phenylpyridinium-induced Mitochondrial Dysfunction and Cell Death in PC12 Cells

Lee DH, Lee CS

  • KMID: 1512942
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):51-58.
The promoting effect of hydrogen peroxide (H2O2) against the cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) in differentiated PC12 cells was assessed by measuring the effect on the mitochondrial membrane permeability. Treatment of...
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Intracellular pH is a Critical Element in Apoptosis Triggered by GM-CSF Deprivation in TF1 Cells

Yoon SR, Choi IP

BACKGROUND: Hemopoietic cells require the constant presence of growth factors for survival in vitro and in vivo. Caspases have been known as central executors of apoptotic cell death. We have,...
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Novel non-apoptotic cell death: ferroptosis

Woo SM, Kwon TK

Ferroptosis is a newly recognized type of cell death that results from iron-dependent lipid peroxidation and is different from other types of cell death, such as apoptosis, necrosis, and autophagic...
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Therapeutic Modulation of Apoptosis: Targeting the BCL-2 Family at the Interface of the Mitochondrial Membrane

Nemec KN, Khaled AR

A vast portion of human disease results when the process of apoptosis is defective. Disorders resulting from inappropriate cell death range from autoimmune and neurodegenerative conditions to heart disease. Conversely,...
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Ultrastructural Changes in Skeletal Muscle of Infants with Mitochondrial Respiratory Chain Complex I Defects

Mun JY, Jung MK, Kim SH, Eom S, Han SS, Lee YM

BACKGROUND AND PURPOSE: The pathogenesis of mitochondrial disease (MD) involves the disruption of cellular energy metabolism, which results from defects in the mitochondrial respiratory chain complex (MRC). We investigated whether...
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Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity

Jeon JH, Kim DK, Shin Y, Kim HY, Song B, Lee EY, Kim JK, You HJ, Cheong H, Shin DH, Kim ST, Cheong JH, Kim SY, Jang H

A small proportion of cancer cells have stem-cell-like properties, are resistant to standard therapy and are associated with a poor prognosis. The metabolism of such drug-resistant cells differs from that...
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Comparison of the Protective Effect of Indole beta-carbolines and R-(-)-deprenyl Against Nitrogen Species-Induced Cell Death in Experimental Culture Model of Parkinson's Disease

Han YS, Kim JM, Cho JS, Lee CS, Kim DE

BACKGROUND: The membrane permeability transition of mitochondria has been suggested to be involved in toxic and oxidative forms of cell injury. Mitochondrial dysfunction is considered to play a critical role...
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Antitumor Effects of Camptothecin Combined with Conventional Anticancer Drugs on the Cervical and Uterine Squamous Cell Carcinoma Cell Line SiHa

Ha SW, Kim YJ, Kim W, Lee CS

Functional defects in mitochondria are involved in the induction of cell death in cancer cells. We assessed the toxic effect of camptothecin against the human cervical and uterine tumor...
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CM1 Ligation Induces Apoptosis via Fas-FasL Interaction in Ramos Cells, but via Down-regulation of Bcl-2 and Subsequent Decrease of Mitochondrial Membrane Potential in Raji Cells

Lee YS, Kim YS, Kim D, Hur DY, Kang JS, Kim YI, Hahm E, Cho D, Hwang YI, Lee WJ

BACKGROUND: CM1 (Centrocyte/-blast Marker I) defined by a mAb developed against concanavalin-A activated PBMC, is expressed specifically on a subpopulation of centroblasts and centrocytes of human germinal center (GC) B...
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Reverse Warburg Effect-Related Mitochondrial Activity and ¹⁸F-FDG Uptake in Invasive Ductal Carcinoma

Choi BW, Jeong YJ, Park SH, Oh HK, Kang S

PURPOSE: We evaluated the relationship between fluorine-18 fluoro-2-deoxy-glucose (¹⁸F-FDG) uptake and mitochondrial activity in cancer cells and investigated the prognostic implications of this relationship in patients with invasive ductal carcinoma...
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Serum Lipid Levels and Fatty Acid Metabolism in the Rat With Adriamycin Induced Cardiomyopathy

Hong YM, Yoon HR

  • KMID: 2207463
  • J Korean Pediatr Soc.
  • 2000 Nov;43(11):1480-1487.
PURPOSE: Adriarnycin induced cardiomyopathy is irreversible and may procede to clinical congestive heart failure. Recently, it has been suggested that adriamycin may exert cardiomyopathy due to inhibition of transport across mitochondrial membranes...
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Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-X(L) involved in cardiotoxin III-induced apoptosis in K562 cells

Yang SH, Chien CM, Lu MC, Lin YH, Hu XW, Lin SR

  • KMID: 1110128
  • Exp Mol Med.
  • 2006 Aug;38(4):435-444.
Cardiotoxin III (CTX III), a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. CTX III-induced K562 cell apoptosis...
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Delayed Human Neutrophil Apoptosis by Trichomonas vaginalis Lysate

Song HO, Lim YS, Moon SJ, Ahn MH, Ryu JS

Neutrophils play an important role in the human immune system for protection against such microorganisms as a protozoan parasite, Trichomonas vaginalis; however, the precise role of neutrophils in the pathogenesis...
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