Chonnam Med J.
1998 Dec;34(2):255-265.
Effect of Ginsenosides on the Lipid Distribution in Rat Tissues
- Affiliations
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- 1Department of Food and Nutrition, College of Home Economics, Chonnam National University, Kwangju, Korea.
- 2Department of Biochemistry, Chonnam National University Medical School, Kwangju, Korea.
- 3Research Institute of Medical Sciences, Chonnam National University, Kwangju, Korea.
Abstract
- The effect of total ginsenosides on the composition and peroxidation of lipids in sera and biomembranes of rats fed high cholesterol diet was studied. Male Wistar rats were divided into four diet groups: 1) control diet, 2) high cholesterol diet, 3) control + ginsenosides diet, and 4) high cholesterol + ginseosides diet groups, and fed each diet for 6 weeks.There was no significant difference in the daily feeding amount of diet and water and in the total weight gain during the experimental diet feeding. Although there was little change in the total cholesterol level in sera, the distribution of cholesterol among lipoproteins was changed significantly. High cholesterol diet increased the LDL-cholesterol and decreased the HDL-cholesterol and ginsenosides decreased significantly the LDL-cholesterol in serum. Although ginsenosides failed to offset completely the increase in the LDL-cholesterol induced by high cholesterol diet, they could partially contrast the increase of LDL-cholesterol with high cholesterol diet. Ginsenosides decreased the phospholipids content in both mitochondrial and microsomal membranes. Ginsenosides diet inhibited lipid peroxidation of mitochondrial membranes, but stimulated the oxidative damage in microsomal membranes significantly.These results suggest that dietary ginsenosides could modulate both metanolism and oxidative damage of lipids in vivo.
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